Search Results - "Bollino, Dominique"

CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration by June, Harry L, Liu, Juan, Warnock, Kaitlin T, Bell, Kimberly A, Balan, Irina, Bollino, Dominique, Puche, Adam, Aurelian, Laure

“…Alcohol dependence is a complex disorder that initiates with episodes of excessive alcohol drinking known as binge drinking. It has a 50-60% risk contribution…”
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A phase 1 study of the amino acid modulator pegcrisantaspase and venetoclax for relapsed/refractory acute myeloid leukemia by Liu, Yuchen, Bollino, Dominique R, Bah, Osman M, Strovel, Erin T, Le, Tien Van, Zarrabi, Jinoos, Philip, Sunita, Lapidus, Rena G, Baer, Maria R, Niyongere, Sandrine, Duong, Vu H, Dougherty, Christine C, Beumer, Jan Hendrik, Caprinolo, Katherine D, Kamangar, Farin, Emadi, Ashkan

“…Glutamine dependency has been shown to be a metabolic vulnerability in acute myeloid leukemia (AML). Prior studies using several in vivo AML models showed that…”
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Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia by Emadi, Ashkan, Kapadia, Bandish, Bollino, Dominique, Bhandary, Binny, Baer, Maria R., Niyongere, Sandrine, Strovel, Erin T., Kaizer, Hannah, Chang, Elizabeth, Choi, Eun Yong, Ma, Xinrong, Tighe, Kayla M., Carter-Cooper, Brandon, Moses, Blake S., Civin, Curt I., Mahurkar, Anup, Shetty, Amol C., Gartenhaus, Ronald B., Kamangar, Farin, Lapidus, Rena G.

“…Complex karyotype acute myeloid leukemia (CK-AML) has a dismal outcome with current treatments, underscoring the need for new therapies. Here, we report…”
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Dual targeting of glutamine and serine metabolism in acute myeloid leukemia by Hameed, Kanwal M, Bollino, Dominique R, Shetty, Amol C, Carter-Cooper, Brandon, Lapidus, Rena G, Emadi, Ashkan

“…Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by disrupted blood cell production and function. Recent investigations…”
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Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses by Webb, Tonya J., Carey, Gregory B., East, James E., Sun, Wenji, Bollino, Dominique R., Kimball, Amy S., Brutkiewicz, Randy R.

“…Natural killer T (NKT) cells play a critical role in the host's innate immune response. CD1d-mediated presentation of glycolipid antigens to NKT cells has been…”
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Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine by Bollino, Dominique, Claiborne, J Preston, Hameed, Kanwal, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Lapidus, Rena G, Strovel, Erin T, Emadi, Ashkan

“…The impact of asparaginases on plasma asparagine and glutamine is well established. However, the effect of asparaginases, particularly those derived from (also…”
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Immunotherapeutic strategies targeting natural killer T cell responses in cancer by Shissler, Susannah C., Bollino, Dominique R., Tiper, Irina V., Bates, Joshua P., Derakhshandeh, Roshanak, Webb, Tonya J.

“…Natural killer T (NKT) cells are a unique subset of lymphocytes that bridge the innate and adaptive immune system. NKT cells possess a classic αβ T cell…”
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Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma by Bollino, Dominique, Hameed, Kanwal, Bhat, Anusha, Zarrabi, Arveen, Casildo, Andrea, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Strovel, Erin T, Lapidus, Rena G, Emadi, Ashkan

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC…”
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Therapeutic targeting of the immunosuppressive axis in ovarian cancer using dietary supplements by Bollino, Dominique, Webb, Tonya J

“…Abstract Ovarian cancer is the deadliest gynecologic malignancy worldwide and mortality rates have remained steady despite advances in treatment. A major…”
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Valproic acid induces neuronal cell death through a novel calpain‐dependent necroptosis pathway by Bollino, Dominique, Balan, Irina, Aurelian, Laure

“…A growing body of evidence indicates that valproic acid (VPA), a histone deacetylase inhibitor used to treat epilepsy and mood disorders, has histone…”
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Chimeric antigen receptor engineered natural killer and natural killer T cells for cancer immunotherapy by Bollino, Dominique, Webb, Tonya J

“…Abstract Natural killer (NK) cells of the innate immune system and natural killer T (NKT) cells, which have roles in both the innate and adaptive responses,…”
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Long-Acting E. coli-Derived Asparaginase Potentiates the Anti-Leukemic Effect of BCL2 Inhibition, but Not MCL1 Inhibition, in Preclinical Models of Acute Myeloid Leukemia by Bollino, Dominique, Casildo, Andrea, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Emadi, Ashkan

“…Background: Asparaginases are enzymes that deplete circulating asparagine and glutamine from plasma and can therefore be used therapeutically for cancers that…”
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Targeting Serine Biosynthesis in Combination with the Modulation of Glutamine Metabolism Enhances Cellular Cytotoxicity in Acute Myeloid Leukemia by Mahmood, Kanwal, Dayal, Neetu, Bollino, Dominique R, Sintim, Herman O, Emadi, Ashkan

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ΔPK oncolytic activity includes modulation of the tumour cell milieu by Bollino, Dominique, Colunga, Aric, Li, Baiquan, Aurelian, Laure

“…Oncolytic virotherapy is a unique cancer therapeutic that encompasses tumour cell lysis through both virus replication and programmed cell death (PCD)…”
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The oncolytic virus ΔPK has multimodal anti-tumor activity by Aurelian, Laure, Bollino, Dominique, Colunga, Aric

“…Oncolytic viruses (OVs) are an emerging cancer therapeutic, with a near complete absence of serious adverse effects. However, clinical efficacy is relatively…”
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Pegcrisantaspase (PegC) Induces an Increase in Plasma Threonine in Patients With Acute Myeloid Leukemia (AML) by Liu, Yuchen, Bollino, Dominique, Strovel, Erin, Lapidus, Rena, Kamangar, Farin, Emadi, Ashkan

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AML-498 Pegcrisantaspase (PegC) Induces an Increase in Plasma Threonine in Patients With Acute Myeloid Leukemia (AML) by Liu, Yuchen, Bollino, Dominique, Strovel, Erin, Lapidus, Rena, Kamangar, Farin, Emadi, Ashkan

“…Glutamine depletion has been reported to be a therapeutic vulnerability in AML that is thought to be mediated by indirect inhibition of the mTOR pathway. We…”
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Comprehensive Plasma Amino Acid Analysis Following Administration of Short- and Long-Acting Erwinia Asparaginase (Crisantaspase) Demonstrated Significant Increase in Plasma Serine and Glycine Levels by Bollino, Dominique R, Claiborne, J Preston, Mahmood, Kanwal, Ma, Xinrong, Tighe, Kayla M, Cooper, Brandon, Lapidus, Rena G., Strovel, Erin T, Emadi, Ashkan

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Targeting the VEGF/GD3 immunosuppressive axis in ovarian cancer by Bollino, Dominique, Muthuswamy, Ravikumar, Odunsi, Kunle, Webb, Tonya J

“…Abstract Ovarian cancer is the fifth leading cause of cancer deaths among women, thereby accounting for more deaths than any other cancer of the female…”
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Overcoming Venetoclax (Ven) Resistance through Glutamine (Gln) Depletion: Final Analysis of the Phase 1 Trial of Ven and Pegcrisantaspase (PegC) Combination in Relapsed and Refractory (R/R) Acute Myeloid Leukemia (AML) by Liu, Yuchen, Bollino, Dominique, Bah, Osman M, Strovel, Erin T, Zarrabi, Jinoos, Philip, Sunita, Mostafa, Ezzat, Lapidus, Rena G, Baer, Maria R., Niyongere, Sandrine, Duong, Vu H., Dougherty, Christine C, Caprinolo, Katherine, Emadi, Ashkan

“…Background: Ven-based therapies have been an advancement in the front-line treatment of AML; however development of resistance is common and the efficacy of…”
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