Search Results - "Boll, Joseph M"

The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer by Henderson, Jeremy C, Zimmerman, Shawn M, Crofts, Alexander A, Boll, Joseph M, Kuhns, Lisa G, Herrera, Carmen M, Trent, M. Stephen

“…Determining the chemical composition of biological materials is paramount to the study of natural phenomena. Here, we describe the composition of model…”
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Colistin heteroresistance in Enterobacter cloacae is regulated by PhoPQ‐dependent 4‐amino‐4‐deoxy‐l‐arabinose addition to lipid A by Kang, Katie N., Klein, Dustin R., Kazi, Misha I., Guérin, François, Cattoir, Vincent, Brodbelt, Jennifer S., Boll, Joseph M.

“…Summary The Enterobacter cloacae complex (ECC) consists of closely related bacteria commonly associated with the human microbiota. ECC are increasingly…”
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Reinforcing Lipid A Acylation on the Cell Surface of Acinetobacter baumannii Promotes Cationic Antimicrobial Peptide Resistance and Desiccation Survival by Boll, Joseph M, Tucker, Ashley T, Klein, Dustin R, Beltran, Alexander M, Brodbelt, Jennifer S, Davies, Bryan W, Trent, M Stephen

“…Acinetobacter baumannii is an emerging Gram-negative pathogen found in hospitals and intensive care units. In order to persist in hospital environments,…”
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Defining gene-phenotype relationships in Acinetobacter baumannii through one-step chromosomal gene inactivation by Tucker, Ashley T, Nowicki, Emily M, Boll, Joseph M, Knauf, Gregory A, Burdis, Nora C, Trent, M Stephen, Davies, Bryan W

“…Rates of infection with hospital-acquired Acinetobacter baumannii have exploded over the past decade due to our inability to limit persistence and effectively…”
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High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications by Murtha, Andrew N, Kazi, Misha I, Schargel, Richard D, Cross, Trevor, Fihn, Conrad, Cattoir, Vincent, Carlson, Erin E, Boll, Joseph M, Dörr, Tobias

“…Antibiotic tolerance is an understudied potential contributor to antibiotic treatment failure and the emergence of multidrug-resistant bacteria. The molecular…”
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Peptidoglycan Recycling Promotes Outer Membrane Integrity and Carbapenem Tolerance in Acinetobacter baumannii by Islam, Nowrosh, Kazi, Misha I, Kang, Katie N, Biboy, Jacob, Gray, Joe, Ahmed, Feroz, Schargel, Richard D, Boutte, Cara C, Dörr, Tobias, Vollmer, Waldemar, Boll, Joseph M

“…β-Lactam antibiotics exploit the essentiality of the bacterial cell envelope by perturbing the peptidoglycan layer, typically resulting in rapid lysis and…”
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Septal Class A Penicillin-Binding Protein Activity and ld-Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii by Kang, Katie N, Kazi, Misha I, Biboy, Jacob, Gray, Joe, Bovermann, Hannah, Ausman, Jessie, Boutte, Cara C, Vollmer, Waldemar, Boll, Joseph M

“…Despite dogma suggesting that lipopolysaccharide/lipooligosaccharide (LOS) was essential for viability of Gram-negative bacteria, several clinical isolates…”
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A regulatory checkpoint during flagellar biogenesis in Campylobacter jejuni initiates signal transduction to activate transcription of flagellar genes by Boll, Joseph M, Hendrixson, David R

“…Many polarly flagellated bacteria require similar two-component regulatory systems (TCSs) and σ(54) to activate transcription of genes essential for flagellar…”
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specificity determinant for phosphorylation in a response regulator prevents in vivo cross-talk and modification by acetyl phosphate by Boll, Joseph M, Hendrixson, David R

“…Bacterial two-component systems (TCSs) sense stimuli and transduce signals intracellularly through phosphotransfer between cognate histidine kinases (HKs) and…”
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A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity by Sapkota, Madhab, Adnan Qureshi, Mohammed, Arif Mahmud, Siraje, Balikosa, Yves, Nguyen, Charlton, Boll, Joseph M, Pellegrino, Mark W

“…A dramatic rise of infections with antibiotic-resistant bacterial pathogens continues to challenge the healthcare field due to the lack of effective treatment…”
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PBP1A Directly Interacts with the Divisome Complex to Promote Septal Peptidoglycan Synthesis in Acinetobacter baumannii by Kang, Katie N, Boll, Joseph M

“…The class A penicillin-binding proteins (aPBPs), PBP1A and PBP1B, are major peptidoglycan synthases that synthesize more than half of the peptidoglycan per…”
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A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii by Boll, Joseph M., Crofts, Alexander A., Peters, Katharina, Cattoir, Vincent, Vollmer, Waldemar, Davies, Bryan W., Trent, M. Stephen

“…The Gram-negative bacterial outer membrane fortifies the cell against environmental toxins including antibiotics. Unique glycolipids called…”
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In Mycobacterium abscessus , the Stringent Factor Rel Regulates Metabolism but Is Not the Only (p)ppGpp Synthase by Hunt-Serracín, Augusto César, Kazi, Misha I, Boll, Joseph M, Boutte, Cara C

“…The stringent response is a broadly conserved stress response system that exhibits functional variability across bacterial clades. Here, we characterize the…”
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Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies by Chen, Linxiao, Valentine, Jenny L., Huang, Chung-Jr, Endicott, Christine E., Moeller, Tyler D., Rasmussen, Jed A., Fletcher, Joshua R., Boll, Joseph M., Rosenthal, Joseph A., Dobruchowska, Justyna, Wang, Zhirui, Heiss, Christian, Azadi, Parastoo, Putnam, David, Trent, M. Stephen, Jones, Bradley D., DeLisa, Matthew P.

“…The O-antigen polysaccharide (O-PS) component of lipopolysaccharides on the surface of gram-negative bacteria is both a virulence factor and a B-cell antigen…”
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Discovery and characterization of New Delhi metallo-β-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae by Kazi, Misha I, Perry, Blair W, Card, Daren C, Schargel, Richard D, Ali, Hana B, Obuekwe, Victor C, Sapkota, Madhab, Kang, Katie N, Pellegrino, Mark W, Greenberg, David E, Castoe, Todd A, Boll, Joseph M

“…Abstract Objectives Metallo-β-lactamases (MBLs) are an emerging class of antimicrobial resistance enzymes that degrade β-lactam antibiotics, including…”
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Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing by Kazi, Misha I, Schargel, Richard D, Boll, Joseph M

“…Transposon sequencing (Tn-seq) is a powerful method that combines transposon mutagenesis and massive parallel sequencing to identify genes and pathways that…”
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UVliPiD: A UVPD-Based Hierarchical Approach for De Novo Characterization of Lipid A Structures by Morrison, Lindsay J, Parker, W. Ryan, Holden, Dustin D, Henderson, Jeremy C, Boll, Joseph M, Trent, M. Stephen, Brodbelt, Jennifer S

“…The lipid A domain of the endotoxic lipopolysaccharide layer of Gram-negative bacteria is comprised of a diglucosamine backbone to which a variable number of…”
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Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni by Fage, Christopher D., Brown, Dusty B., Boll, Joseph M., Keatinge-Clay, Adrian T., Trent, M. Stephen

“…The foodborne enteric pathogen Campylobacter jejuni decorates a variety of its cell‐surface structures with phosphoethanolamine (pEtN). Modifying lipid A with…”
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