Search Results - "Bolinger, Andrew A"

Exploring New Vista for Alzheimer's Disease Drug Targets (Part II) by Bolinger, Andrew A, Zhou, Jia

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Highlights on Fluorine-containing Drugs Approved by U.S. FDA in 2023 by Ali, Saghir, Bolinger, Andrew A, Zhou, Jia

“…Fluorine continues to show its potential applications in drug discovery and development, as reflected by twelve drugs being fluorinated out of the fifty-five…”
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RIPTACs: A groundbreaking approach to drug discovery by Ma, Zonghui, Bolinger, Andrew A., Zhou, Jia

“…•A groundbreaking drug discovery approach using regulated induced proximity targeting chimeras (RIPTACs) is introduced.•Proof-of-concept and preliminary…”
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Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2) by Ma, Zonghui, Bolinger, Andrew A., Chen, Haiying, Zhou, Jia

“…Nuclear receptor binding SET domain proteins (NSDs) catalyze the mono- or dimethylation of histone 3 lysine 36 (H3K36me1 and H3K36me2), using…”
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Novel approaches to targeted protein degradation technologies in drug discovery by Xue, Yu, Bolinger, Andrew A, Zhou, Jia

“…Target protein degradation (TPD) provides a novel therapeutic modality, other than inhibition, through the direct depletion of target proteins. Two primary…”
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Bromodomain-containing protein 4 (BRD4): a key player in inflammatory bowel disease and potential to inspire epigenetic therapeutics by Ma, Zonghui, Bolinger, Andrew A, Zhou, Jia, Tian, Bing

“…Inflammatory bowel diseases (IBDs) are debilitating chronic inflammatory disorders with increasing prevalence worldwide. Epigenetic regulator…”
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Therapeutic potential of salicylamide derivatives for combating viral infections by Xu, Jimin, Xue, Yu, Bolinger, Andrew A., Li, Jun, Zhou, Mingxiang, Chen, Haiying, Li, Hongmin, Zhou, Jia

“…Since time immemorial human beings have constantly been fighting against viral infections. The ongoing and devastating coronavirus disease 2019 pandemic…”
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Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases by Li, Yi, Chen, Jianping, Bolinger, Andrew A, Chen, Haiying, Liu, Zhiqing, Cong, Yingzi, Brasier, Allan R, Pinchuk, Irina V, Tian, Bing, Zhou, Jia

“…Abstract Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a class of severe and chronic diseases of the…”
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Design, synthesis, and pharmacological evaluations of pyrrolo[1,2-a]quinoxaline-based derivatives as potent and selective sirt6 activators by Xu, Jimin, Shi, Shuizhen, Liu, Gang, Xie, Xuping, Li, Jun, Bolinger, Andrew A., Chen, Haiying, Zhang, Wenbo, Shi, Pei-Yong, Liu, Hua, Zhou, Jia

“…Sirt6 activation has emerged as a promising drug target for the treatment of various human diseases, while only limited Sirt6 activators have been reported…”
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Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target by Bolinger, Andrew A., Frazier, Andrew, La, Jun-Ho, Allen, John A., Zhou, Jia

“…G protein-coupled receptors (GPCRs) are successful druggable targets, making up around 35% of all FDA-approved medications. However, a large number of…”
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Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5‑HT2C Receptor and Dual 5‑HT2C/5-HT2A Receptor Modulators by Chen, Jianping, Garcia, Erik J., Merritt, Christina R., Zamora, Joshua C., Bolinger, Andrew A., Pazdrak, Konrad, Stafford, Susan J., Mifflin, Randy C., Wold, Eric A., Wild, Christopher T., Chen, Haiying, Anastasio, Noelle C., Cunningham, Kathryn A., Zhou, Jia

“…The serotonin 5-HT2A receptor (5-HT2AR) and 5-HT2CR localize to the brain and share overlapping signal transduction facets that contribute to their roles in…”
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Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT 2C Receptor and Dual 5-HT 2C /5-HT 2A Receptor Modulators by Chen, Jianping, Garcia, Erik J, Merritt, Christina R, Zamora, Joshua C, Bolinger, Andrew A, Pazdrak, Konrad, Stafford, Susan J, Mifflin, Randy C, Wold, Eric A, Wild, Christopher T, Chen, Haiying, Anastasio, Noelle C, Cunningham, Kathryn A, Zhou, Jia

“…The serotonin 5-HT receptor (5-HT R) and 5-HT R localize to the brain and share overlapping signal transduction facets that contribute to their roles in…”
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