Search Results - "Boles, Nathan C."

CORTECON: A Temporal Transcriptome Analysis of In Vitro Human Cerebral Cortex Development from Human Embryonic Stem Cells by van de Leemput, Joyce, Boles, Nathan C., Kiehl, Thomas R., Corneo, Barbara, Lederman, Patty, Menon, Vilas, Lee, Changkyu, Martinez, Refugio A., Levi, Boaz P., Thompson, Carol L., Yao, Shuyuan, Kaykas, Ajamete, Temple, Sally, Fasano, Christopher A.

“…Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer understanding of the molecular processes underlying human corticogenesis…”
Get full text

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing by Ergen, Aysegul V., Boles, Nathan C., Goodell, Margaret A.

“…HSCs undergo dramatic changes with aging. An increase in absolute numbers of HSCs along with a functional deficit in reconstitution potential and a shift…”
Get full text

Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration by Saini, Janmeet S., Corneo, Barbara, Miller, Justine D., Kiehl, Thomas R., Wang, Qingjie, Boles, Nathan C., Blenkinsop, Timothy A., Stern, Jeffrey H., Temple, Sally

“…Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell monolayer essential for photoreceptor survival, and is the leading…”
Get full text

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1 by Challen, Grant A., Boles, Nathan C., Chambers, Stuart M., Goodell, Margaret A.

“…The traditional view of hematopoiesis has been that all the cells of the peripheral blood are the progeny of a unitary homogeneous pool of hematopoietic stem…”
Get full text

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice by Rossi, Lara, Lin, Kuanyin K., Boles, Nathan C., Yang, Liubin, King, Katherine Y., Jeong, Mira, Mayle, Allison, Goodell, Margaret A.

“…Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC…”
Get full text

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids by Bowles, Kathryn R., Silva, M. Catarina, Whitney, Kristen, Bertucci, Taylor, Berlind, Joshua E., Lai, Jesse D., Garza, Jacob C., Boles, Nathan C., Mahali, Sidhartha, Strang, Kevin H., Marsh, Jacob A., Chen, Cynthia, Pugh, Derian A., Liu, Yiyuan, Gordon, Ronald E., Goderie, Susan K., Chowdhury, Rebecca, Lotz, Steven, Lane, Keith, Crary, John F., Haggarty, Stephen J., Karch, Celeste M., Ichida, Justin K., Goate, Alison M., Temple, Sally

“…Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms…”
Get full text

Retraction Notice to: NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells by Boles, Nathan C., Hirsch, Sarah E., Le, Sheila, Corneo, Barbara, Najm, Fadi, Minotti, Andrew P., Wang, Qingjie, Lotz, Steven, Tesar, Paul J., Fasano, Christopher A.

Get full text

Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells by Ganapathi, Mythily, Boles, Nathan C., Charniga, Carol, Lotz, Steven, Campbell, Melissa, Temple, Sally, Morse, Randall H.

“…The ability of isolated neural stem cells (NSCs) to proliferate as neurospheres is indicative of their competence as stem cells, and depends critically on the…”
Get full text

NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells by Boles, Nathan C., Hirsch, Sarah E., Le, Sheila, Corneo, Barbara, Najm, Fadi, Minotti, Andrew P., Wang, Qingjie, Lotz, Steven, Tesar, Paul J., Fasano, Christopher A.

“…Neural induction is the first fundamental step in nervous system formation. During development, a tightly regulated niche modulates transient extracellular…”
Get full text

Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation by Xu, An, Liu, Mo, Huang, Mo-Fan, Zhang, Yang, Hu, Ruifeng, Gingold, Julian A., Liu, Ying, Zhu, Dandan, Chien, Chian-Shiu, Wang, Wei-Chen, Liao, Zian, Yuan, Fei, Hsu, Chih-Wei, Tu, Jian, Yu, Yao, Rosen, Taylor, Xiong, Feng, Jia, Peilin, Yang, Yi-Ping, Bazer, Danielle A., Chen, Ya-Wen, Li, Wenbo, Huff, Chad D., Zhu, Jay-Jiguang, Aguilo, Francesca, Chiou, Shih-Hwa, Boles, Nathan C., Lai, Chien-Chen, Hung, Mien-Chie, Zhao, Zhongming, Van Nostrand, Eric L., Zhao, Ruiying, Lee, Dung-Fang

“…N6-methyladenosine (m 6 A), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role in modulating both biological and pathological…”
Get full text

In Pursuit of Authenticity: Induced Pluripotent Stem Cell‐Derived Retinal Pigment Epithelium for Clinical Applications by Miyagishima, Kiyoharu J., Wan, Qin, Corneo, Barbara, Sharma, Ruchi, Lotfi, Mostafa R., Boles, Nathan C., Hua, Fang, Maminishkis, Arvydas, Zhang, Congxiao, Blenkinsop, Timothy, Khristov, Vladimir, Jha, Balendu S., Memon, Omar S., D’Souza, Sunita, Temple, Sally, Miller, Sheldon S., Bharti, Kapil

“…For effective treatment, induced pluripotent stem cell (iPSC)‐retinal pigment epithelium (RPE) must recapitulate the physiology of native human RPE cells. A…”
Get full text

CD150− side population cells represent a functionally distinct population of long-term hematopoietic stem cells by Weksberg, David C., Chambers, Stuart M., Boles, Nathan C., Goodell, Margaret A.

“…Hematopoietic stem cells (HSCs) are a self-renewing population of bone marrow cells that replenish the cellular elements of blood throughout life. HSCs…”
Get full text

Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells by Berg, Jonathan S, Lin, Kuanyin K, Sonnet, Corinne, Boles, Nathan C, Weksberg, David C, Nguyen, Hoang, Holt, Lowenna J, Rickwood, Danny, Daly, Roger J, Goodell, Margaret A

“…Lifelong, many somatic tissues are replenished by specialized adult stem cells. These stem cells are generally rare, infrequently dividing, occupy a unique…”
Get full text

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling by King, Katherine Y., Baldridge, Megan T., Weksberg, David C., Chambers, Stuart M., Lukov, Georgi L., Wu, Shihua, Boles, Nathan C., Jung, Sung Yun, Qin, Jun, Liu, Dan, Songyang, Zhou, Eissa, N. Tony, Taylor, Gregory A., Goodell, Margaret A.

“…The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis. Previously we demonstrated that…”
Get full text

Non-monotonic Changes in Progenitor Cell Behavior and Gene Expression during Aging of the Adult V-SVZ Neural Stem Cell Niche by Apostolopoulou, Maria, Kiehl, Thomas R., Winter, Mark, Cardenas De La Hoz, Edgar, Boles, Nathan C., Bjornsson, Christopher S., Zuloaga, Kristen L., Goderie, Susan K., Wang, Yue, Cohen, Andrew R., Temple, Sally

“…Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by…”
Get full text

CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway by Lin, Kuanyin K, Rossi, Lara, Boles, Nathan C, Hall, Brian E, George, Thaddeus C, Goodell, Margaret A

“…The regulatory mechanisms governing the cell cycle progression of hematopoietic stem cells (HSCs) are well characterized, but those responsible for the return…”
Get full text

CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation by Boles, Nathan C., Lin, Kuanyin K., Lukov, Georgi L., Bowman, Teresa V., Baldridge, Megan T., Goodell, Margaret A.

“…The proliferation and differentiation of adult stem cells is balanced to ensure adequate generation of differentiated cells, stem cell homeostasis, and guard…”
Get full text

Epimetronomics: m6A Marks the Tempo of Corticogenesis by Boles, Nathan C., Temple, Sally

“…Yoon et al. (2017) uncover a key role for the m6A RNA mark in regulating the timing of cerebral cortex development in mouse and human. This discovery opens new…”
Get full text

Chk1 haploinsufficiency results in anemia and defective erythropoiesis by Boles, Nathan C, Peddibhotla, Sirisha, Chen, Alice J, Goodell, Margaret A, Rosen, Jeffrey M

“…Erythropoiesis is a highly regulated and well-characterized developmental process responsible for providing the oxygen transport system of the body. However,…”
Get full text

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection by Baldridge, Megan T., King, Katherine Y., Boles, Nathan C., Weksberg, David C., Goodell, Margaret A.

“…Response to chronic bacterial infection Using a mouse model of bacterial infection, Baldridge et al . show that infection with Mycobacterium avium exerts a…”
Get full text