Search Results - "Boles, Jake"

Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease by Butkovich, Laura M, Houser, Madelyn C, Chalermpalanupap, Termpanit, Porter-Stransky, Kirsten A, Iannitelli, Alexa F, Boles, Jake S, Lloyd, Grace M, Coomes, Alexandra S, Eidson, Lori N, De Sousa Rodrigues, Maria Elizabeth, Oliver, Danielle L, Kelly, Sean D, Chang, Jianjun, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Giasson, Benoit I, Joers, Valerie, Weinshenker, David, Tansey, Malú Gámez

“…Degeneration of locus ceruleus (LC) neurons and dysregulation of noradrenergic signaling are ubiquitous features of Parkinson's disease (PD). The LC is among…”
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Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats by Yegla, Brittney, Boles, Jake, Kumar, Ashok, Foster, Thomas C.

“…The role of microglia in mediating age‐related changes in cognition and hippocampal synaptic function was examined by microglial depletion and replenishment…”
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Loss of Progranulin Results in Increased Pan‐Cathepsin Expression by Anderson, Abigail, Gillett, Drew A, Boles, Jake, Wallings, Rebecca L, Tansey, Malu Gámez

“…Background Mutations in the progranulin (PGRN) encoding gene, GRN, cause familial frontotemporal dementia (FTD) and neuronal ceroid lipofuscinosis and is also…”
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Neural stem cell biodistribution visualization by 3D immunolabeling in Sanfilippo syndrome disease models by Ashby, Frederick, Sommerville, John, Boles, Jake, Kabbej, Nadia, Andraka, Natalia, Traktuev, Dimitry, Heldermon, Coy

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A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis by Boles, Jake Sondag, Krueger, Maeve E., Jernigan, Janna E., Cole, Cassandra L., Neighbarger, Noelle K., Uriarte Huarte, Oihane, Tansey, Malú Gámez

“…•Molecular features of DSS-induced colitis were broadly reproducible across studies.•Colitis caused systemic innate immune activation that was severe but…”
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High fidelity: Assessing zebrafish (Danio rerio) responses to social stimuli across several levels of realism by Velkey, Andrew J., Boles, Jake, Betts, Taylor K., Kay, Heather, Henenlotter, Rebecca, Wiens, Katie M.

“…•Zebrafish can distinguish between a live shoal and simulations of conspecifics.•Zebrafish prefer live shoals when simultaneously presented with a live shoal…”
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