Search Results - "Bole, Leonie J."

Enhancing Metalating Efficiency of the Sodium Amide NaTMP in Arene Borylation Applications by Bole, Leonie J., Tortajada, Andreu, Hevia, Eva

“…Though LiTMP (TMP=2,2′,6,6′‐tetramethylpiperidide) is a commonly used amide, surprisingly the heavier NaTMP has hardly been utilised. Here, by mixing NaTMP…”
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Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents by Fairley, Michael, Bole, Leonie J, Mulks, Florian F, Main, Laura, Kennedy, Alan R, O'Hara, Charles T, García-Alvarez, Joaquín, Hevia, Eva

“…Lithium amides constitute one of the most commonly used classes of reagents in synthetic chemistry. However, despite having many applications, their use is…”
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Preparation of Polyfunctional Arylzinc Organometallics in Toluene by Halogen/Zinc Exchange Reactions by Balkenhohl, Moritz, Ziegler, Dorothée S., Desaintjean, Alexandre, Bole, Leonie J., Kennedy, Alan R., Hevia, Eva, Knochel, Paul

“…A wide range of polyfunctional diaryl‐ and diheteroarylzinc species were prepared in toluene within 10 min to 5 h through an I/Zn or Br/Zn exchange reaction…”
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Untangling the Complexity of Mixed Lithium/Magnesium Alkyl/Alkoxy Combinations Utilised in Bromine/Magnesium Exchange Reactions by Bole, Leonie J., Judge, Neil R., Hevia, Eva

“…While it is known that the addition of Group 1 alkoxides to s‐block organometallics can have an activating effect on reactivity, the exact nature of this…”
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Assessing Alkali‐Metal Effects in the Structures and Reactivity of Mixed‐Ligand Alkyl/Alkoxide Alkali‐Metal Magnesiates by Judge, Neil R., Bole, Leonie J., Hevia, Eva

“…Advancing the understanding of using alkali‐metal alkoxides as additives to organomagnesium reagents in Mg−Br exchange reactions, a homologous series of…”
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Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles by Desaintjean, Alexandre, Haupt, Tobias, Bole, Leonie J., Judge, Neil R., Hevia, Eva, Knochel, Paul

“…Using the bimetallic combination sBu2Mg⋅2 LiOR (R=2‐ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo‐arenes and…”
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Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br) by Kremsmair, Alexander, Sunagatullina, Alisa S., Bole, Leonie J., Mastropierro, Pasquale, Graßl, Simon, Wilke, Henrik R., Godineau, Edouard, Hevia, Eva, Knochel, Paul

“…A new method for regioselective zincations of challenging N‐heterocyclic substrates such as pyrimidines and pyridazine was reported using bimetallic bases…”
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Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights by Dell'Aera, Marzia, Perna, Filippo Maria, Vitale, Paola, Altomare, Angela, Palmieri, Alessandro, Maddock, Lewis C. H., Bole, Leonie J., Kennedy, Alan R., Hevia, Eva, Capriati, Vito

“…We report the first transition metal catalyst‐ and ligand‐free conjugate addition of lithium tetraorganozincates (R4ZnLi2) to nitroolefins. Displaying enhanced…”
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Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali‐Metal Amides under Air by Mulks, Florian F., Bole, Leonie J., Davin, Laia, Hernán‐Gómez, Alberto, Kennedy, Alan, García‐Álvarez, Joaquín, Hevia, Eva

“…A straightforward alkali‐metal‐mediated hydroamination of styrenes using biorenewable 2‐methyltetrahydrofuran as a solvent is reported. Refuting the…”
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Sodium mediated deprotonative borylation of arenes using sterically demanding B(CH 2 SiMe 3 ) 3 : unlocking polybasic behaviour and competing lateral borane sodiation by Tortajada, Andreu, Bole, Leonie J, Mu, Manting, Stanford, Martin, Peñas-Defrutos, Marconi N, García-Melchor, Max, Hevia, Eva

“…The deprotonative metalation of organic molecules has become a convenient route to prepare functionalised aromatic substrates. Amongst the different…”
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Progressing the Frustrated Lewis Pair Abilities of N‑Heterocyclic Carbene/GaR3 Combinations for Catalytic Hydroboration of Aldehydes and Ketones by Bole, Leonie J, Uzelac, Marina, Hernán-Gómez, Alberto, Kennedy, Alan R, O’Hara, Charles T, Hevia, Eva

“…Exploiting the steric incompatibility of the tris­(alkyl)­gallium GaR3 (R = CH2SiMe3) and the bulky N-heterocyclic carbene (NHC)…”
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Enhancing Metalating Efficiency of the Sodium Amide NaTMP in Arene Borylation Applications by Bole, Leonie J., Tortajada, Andreu, Hevia, Eva

“…Though LiTMP (TMP=2,2′,6,6′‐tetramethylpiperidide) is a commonly used amide, surprisingly the heavier NaTMP has hardly been utilised. Here, by mixing NaTMP…”
Get full text

Untangling the Complexity of Mixed Lithium/Magnesium Alkyl/Alkoxy Combinations Utilised in Bromine/Magnesium Exchange Reactions by Bole, Leonie J., Judge, Neil R., Hevia, Eva

“…While it is known that the addition of Group 1 alkoxides to s‐block organometallics can have an activating effect on reactivity, the exact nature of this…”
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Regioselektiver Brom/Magnesium‐Austausch für die selektive Funktionalisierung von polyhalogenierten Arenen und Heterozyklen by Desaintjean, Alexandre, Haupt, Tobias, Bole, Leonie J., Judge, Neil R., Hevia, Eva, Knochel, Paul

“…Die Verwendung der bimetallischen Kombination sBu2Mg⋅2 LiOR (R=2‐Ethylhexyl) in Toluol ermöglicht einen effizienten und regioselektiven Br/Mg‐Austausch mit…”
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Ausnutzung von Koordinationseffekten für die Regioselektive Zinkierung von Diazinen mit TMPZnX⋅LiX (X=Cl, Br) by Kremsmair, Alexander, Sunagatullina, Alisa S., Bole, Leonie J., Mastropierro, Pasquale, Graßl, Simon, Wilke, Henrik R., Godineau, Edouard, Hevia, Eva, Knochel, Paul

“…Eine neue Methode für regioselektive Zinkierung von anspruchsvollen N‐heterozyklischen Substraten wie Pyrimidinen und Pyridazin wurde unter Verwendung der…”
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Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali‐Metal Amides under Air by Mulks, Florian F., Bole, Leonie J., Davin, Laia, Hernán‐Gómez, Alberto, Kennedy, Alan, García‐Álvarez, Joaquín, Hevia, Eva

“…A straightforward alkali‐metal‐mediated hydroamination of styrenes using biorenewable 2‐methyltetrahydrofuran as a solvent is reported. Refuting the…”
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Herstellung von polyfunktionellen Arylzinkreagenzien in Toluol mittels Halogen/Zink‐Austauschreaktionen by Balkenhohl, Moritz, Ziegler, Dorothée S., Desaintjean, Alexandre, Bole, Leonie J., Kennedy, Alan R., Hevia, Eva, Knochel, Paul

“…Unter Verwendung von bimetallischen Reagenzien des Typs R′2Zn⋅2 LiOR (R′=sBu, tBu, pTol) wurde innerhalb von 10 min bis 5 h in Toluol eine breite Menge an…”
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Activation of polar organometallic reagents with alkali-metal alkoxides by Bole, Leonie J., Hevia, Eva

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Progressing the Frustrated Lewis Pair Abilities of N-Heterocyclic Carbene/GaR 3 Combinations for Catalytic Hydroboration of Aldehydes and Ketones by Bole, Leonie J., Uzelac, Marina, Hernán-Gómez, Alberto, Kennedy, Alan R., O’Hara, Charles T., Hevia, Eva

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Sodium mediated deprotonative borylation of arenes using sterically demanding B(CHSiMe): unlocking polybasic behaviour and competing lateral borane sodiation by Tortajada, Andreu, Bole, Leonie J, Mu, Manting, Stanford, Martin, Peñas-Defrutos, Marconi N, García-Melchor, Max, Hevia, Eva

“…The deprotonative metalation of organic molecules has become a convenient route to prepare functionalised aromatic substrates. Amongst the different…”
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