Search Results - "Bolduc, Philippe N."

Synthesis of N‑Substituted 3‑Amino-2-pyridones by Bolduc, Philippe N., Pfaffenbach, Magnus, Blasczak, Vanna D., Mathieu, Steven R., Peterson, Emily A.

“…Pyridones are versatile building blocks in organic synthesis and a privileged motif in drug discovery. However, N-substituted 2-pyridones bearing an α-tertiary…”
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Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis by Palkowitz, Maximilian D., Laudadio, Gabriele, Kolb, Simon, Choi, Jin, Oderinde, Martins S., Ewing, Tamara El-Hayek, Bolduc, Philippe N., Chen, TeYu, Zhang, Hao, Cheng, Peter T. W., Zhang, Benxiang, Mandler, Michael D., Blasczak, Vanna D., Richter, Jeremy M., Collins, Michael R., Schioldager, Ryan L., Bravo, Martin, Dhar, T. G. Murali, Vokits, Benjamin, Zhu, Yeheng, Echeverria, Pierre-Georges, Poss, Michael A., Shaw, Scott A., Clementson, Sebastian, Petersen, Nadia Nasser, Mykhailiuk, Pavel K., Baran, Phil S.

“…A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo­(hetero)­arenes is…”
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Carbon quaternization of redox active esters and olefins by decarboxylative coupling by Gan, Xu-Cheng, Zhang, Benxiang, Dao, Nathan, Bi, Cheng, Pokle, Maithili, Kan, Liyan, Collins, Michael R, Tyrol, Chet C, Bolduc, Philippe N, Nicastri, Michael, Kawamata, Yu, Baran, Phil S, Shenvi, Ryan

“…The synthesis of quaternary carbons often requires numerous steps and complex conditions or harsh reagents that act on heavily engineered substrates. This is…”
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The Discovery of 7‑Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)‑N‑(6-methylpyrazolo[1,5‑a]pyrimidin-3-yl)imidazo[1,2‑a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke by Evans, Ryan, Bolduc, Philippe N., Pfaffenbach, Magnus, Gao, Fang, May-Dracka, Tricia, Fang, Terry, Hopkins, Brian T., Chodaparambil, Jayanth V, Henry, Kate L., Li, Pei, Metrick, Claire, Nelson, Ashley, Trapa, Patrick, Thomas, Ankur, Burkly, Linda, Peterson, Emily A.

“…Interleukin receptor-associated kinase 4 (IRAK4) is a key node of signaling within the innate immune system that regulates the production of inflammatory…”
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Discovery of BIO-8169A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation by Pfaffenbach, Magnus, Bolduc, Philippe N., Xin, Zhili, Gao, Fang, Evans, Ryan, Fang, Terry, Chodaparambil, Jayanth V., Henry, Kate L., Li, Pei, Mathieu, Steven, Metrick, Claire, Vera Rebollar, Jorge A., Gu, Rong-Fang, Mccarl, Christie-Ann, Silbereis, John, Peterson, Emily A.

“…Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and…”
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Synthesis of Unnatural Amino Acids via Ni/Ag Electrocatalytic Cross-Coupling by Laudadio, Gabriele, Neigenfind, Philipp, Chebolu, Rajesh, Blasczak, Vanna D., Maddirala, Shambabu Joseph, Palkowitz, Maximilian D., Bolduc, Philippe N., Nicastri, Michael C., Puthukanoori, Ravi Kumar, Paraselli, Bheema Rao, Baran, Phil S.

“…A simple protocol is outlined herein for rapid access to enantiopure unnatural amino acids (UAAs) from trivial glutamate and aspartate precursors. The method…”
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Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling by Zhang, Benxiang, He, Jiayan, Gao, Yang, Levy, Laura, Oderinde, Martins S., Palkowitz, Maximilian D., Dhar, T. G. Murali, Mandler, Michael D., Collins, Michael R., Schmitt, Daniel C., Bolduc, Philippe N., Chen, TeYu, Clementson, Sebastian, Petersen, Nadia Nasser, Laudadio, Gabriele, Bi, Cheng, Kawamata, Yu, Baran, Phil S.

“…Modern retrosynthetic analysis in organic chemistry is based on the principle of polar relationships between functional groups to guide the design of synthetic…”
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Nickel‐Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers by Laudadio, Gabriele, Neigenfind, Philipp, Péter, Áron, Rubel, Camille Z., Emmanuel, Megan A., Oderinde, Martins S., Ewing, Tamara El‐Hayek, Palkowitz, Maximilian D., Sloane, Jack L., Gillman, Kevin W., Ridge, Daniel, Mandler, Michael D., Bolduc, Philippe N., Nicastri, Michael C., Zhang, Benxiang, Clementson, Sebastian, Petersen, Nadia Nasser, Martín‐Gago, Pablo, Mykhailiuk, Pavel, Engle, Keary M., Baran, Phil S.

“…There is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to…”
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A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors by Bolduc, Philippe N., Pfaffenbach, Magnus, Evans, Ryan, Xin, Zhili, Henry, Kate L., Gao, Fang, Fang, Terry, Silbereis, John, Vera Rebollar, Jorge, Li, Pei, Chodaparambil, Jayanth V, Metrick, Claire, Peterson, Emily A.

“…We herein report the discovery, synthesis, and evolution of a series of indazoles and azaindazoles as CNS-penetrant IRAK4 inhibitors. Described is the use of…”
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Nickel‐Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers by Laudadio, Gabriele, Neigenfind, Philipp, Péter, Áron, Rubel, Camille Z., Emmanuel, Megan A., Oderinde, Martins S., Ewing, Tamara El‐Hayek, Palkowitz, Maximilian D., Sloane, Jack L., Gillman, Kevin W., Ridge, Daniel, Mandler, Michael D., Bolduc, Philippe N., Nicastri, Michael C., Zhang, Benxiang, Clementson, Sebastian, Petersen, Nadia Nasser, Martín‐Gago, Pablo, Mykhailiuk, Pavel, Engle, Keary M., Baran, Phil S.

“…There is a pressing need, particularly in the field of drug discovery, for general methods that will enable direct coupling of tertiary alkyl fragments to…”
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