Search Results - "Bolduan, Sebastian"

HIV-1 Vpu mediated downregulation of CD155 requires alanine residues 10, 14 and 18 of the transmembrane domain by Bolduan, Sebastian, Reif, Tatjana, Schindler, Michael, Schubert, Ulrich

“…Abstract HIV-1 NL4-3 Vpu induces downregulation of cell surface CD155, a ligand for the DNAM-1 activating receptor of NK and CD8+ T cells, to evade NK cell…”
Get full text

Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317 by Bolduan, Sebastian, Votteler, Jörg, Lodermeyer, Veronika, Greiner, Timo, Koppensteiner, Herwig, Schindler, Michael, Thiel, Gerhard, Schubert, Ulrich

“…Abstract While the C-terminal domain of HIV-1 Vpu is critical for CD4 degradation, the transmembrane domain (TM) mediates ion channel activity, enhances virus…”
Get full text

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A by Bolduan, Sebastian, Hubel, Philipp, Reif, Tatjana, Lodermeyer, Veronika, Höhne, Kristin, Fritz, Joëlle V, Sauter, Daniel, Kirchhoff, Frank, Fackler, Oliver T, Schindler, Michael, Schubert, Ulrich

“…Abstract HIV-1 Vpu induces downregulation of cell surface NTB-A to evade lysis of HIV-1 infected cells by NK cells. Here we show that Vpu affects the…”
Get full text

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication by Hofmann, Stephan, Dehn, Sandra, Businger, Ramona, Bolduan, Sebastian, Schneider, Martha, Debyser, Zeger, Brack-Werner, Ruth, Schindler, Michael

“…Viruses interact with multiple host cell factors. Some of these are required to promote viral propagation, others have roles in inhibiting infection. Here, we…”
Get full text

Ion Channel Activity of Vpu Proteins Is Conserved throughout Evolution of HIV-1 and SIV by Greiner, Timo, Bolduan, Sebastian, Hertel, Brigitte, Groß, Christine, Hamacher, Kay, Schubert, Ulrich, Moroni, Anna, Thiel, Gerhard

“…The human immunodeficiency virus type 1 (HIV-1) protein Vpu is encoded exclusively by HIV-1 and related simian immunodeficiency viruses (SIVs). The…”
Get full text

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection by Höhne, Kristin, Businger, Ramona, van Nuffel, Anouk, Bolduan, Sebastian, Koppensteiner, Herwig, Baeyens, Ann, Vermeire, Jolien, Malatinkova, Eva, Verhasselt, Bruno, Schindler, Michael

“…The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions,…”
Get full text

Analysis of determinants in filovirus glycoproteins required for tetherin antagonism by Gnirß, Kerstin, Fiedler, Marie, Krämer-Kühl, Annika, Bolduan, Sebastian, Mittler, Eva, Becker, Stephan, Schindler, Michael, Pöhlmann, Stefan

“…The host cell protein tetherin can restrict the release of enveloped viruses from infected cells. The HIV-1 protein Vpu counteracts tetherin by removing it…”
Get full text

HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes by Vassena, Lia, Giuliani, Erica, Koppensteiner, Herwig, Bolduan, Sebastian, Schindler, Michael, Doria, Margherita

“…Leukocyte recirculation between blood and lymphoid tissues is required for the generation and maintenance of immune responses against pathogens and is…”
Get full text

T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV‐1 patients by Bolduan, Sebastian, Koppensteiner, Herwig, Businger, Ramona, Rebensburg, Stephanie, Kunze, Christine, Brack‐Werner, Ruth, Draenert, Rika, Schindler, Michael

“…Introduction: Restriction factors (RFs) suppress HIV‐1 in cell lines and primary cell models. Hence, RFs might be attractive targets for novel antiviral…”
Get full text

Virale Interferenz Am Beispiel Der Wechselwirkung Der Zelloberflächenrezeptoren Tetherin Und NTB-A Mit Dem Regulatorischen HIV-1 Protein Vpu by Bolduan, Sebastian

“…Das Ziel dieser Arbeit war es zu analysieren, wie das akzessorische Vpu Protein des Humanen Immundefizienz-Virus Typ 1 (HIV-1) die antivirale Aktivität des…”
Get full text