Search Results - "Boldt, Sherri"

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  1. 1
    In vitro cytochrome P450 inhibition and induction

    In vitro cytochrome P450 inhibition and induction by Walsky, Robert L, Boldt, Sherri E

    Published in Current drug metabolism (01-11-2008)
    “…The assessment of in vitro inhibition and induction of the cytochrome P450 enzymes of the liver is a critical part of the drug discovery and development…”
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  2. 2
    A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

    A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro by FAHMI, Odette A, MAURER, Tristan S, KISH, Mary, CARDENAS, Edwin, BOLDT, Sherri, NETTLETON, David

    Published in Drug metabolism and disposition (01-08-2008)
    “…Although approaches to the prediction of drug-drug interactions (DDIs) arising via time-dependent inactivation have recently been developed, such approaches do…”
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  3. 3
    Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes

    Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes by Fahmi, Odette A, Kish, Mary, Boldt, Sherri, Obach, R Scott

    Published in Drug metabolism and disposition (01-09-2010)
    “…Induction of cytochrome P450 (P450) activity in the clinic can result in therapeutic failure such as tissue rejection in transplant patients or unwanted…”
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  4. 4
    The PPARα Agonists Fenofibrate and CP-778875 Cause Increased β-Oxidation, Leading to Oxidative Injury in Skeletal and Cardiac Muscle in the Rat

    The PPARα Agonists Fenofibrate and CP-778875 Cause Increased β-Oxidation, Leading to Oxidative Injury in Skeletal and Cardiac Muscle in the Rat by Pettersen, John C., Pruimboom-Brees, Ingrid, Francone, Omar L., Amacher, David E., Boldt, Sherri E., Kerlin, Roy L., Ballinger, William E.

    Published in Toxicologic pathology (01-04-2012)
    “…Weak peroxisome proliferator–activated receptor (PPAR) α agonists (fibrates) are used to treat dyslipidemia. This study compared the effects of the potent and…”
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  5. 5
    The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies

    The relationship among microsomal enzyme induction, liver weight, and histological change in cynomolgus monkey toxicology studies by Amacher, David E., Schomaker, Shelli J., Boldt, Sherri E., Mirsky, Michael

    Published in Food and chemical toxicology (01-04-2006)
    “…The purpose of this investigation was to examine the relationship among hepatic microsomal enzyme induction, liver weight, histological evidence of hepatic…”
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  6. 6
    PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA : Application of the Relative Induction Score Approach Using Cryopreserved Human Hepatocytes

    PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA : Application of the Relative Induction Score Approach Using Cryopreserved Human Hepatocytes by FAHMI, Odette A, BOLDT, Sherri, KISH, Mary, OBACH, R. Scott, TREMAINE, Larry M

    Published in Drug metabolism and disposition (01-09-2008)
    “…Cytochrome P450 induction-mediated drug-drug interaction (DDI) is one of the major concerns in clinical practice and for the pharmaceutical industry…”
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  7. 7
    PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA

    PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA by Odette A. Fahmi, Sherri Boldt, Mary Kish, R. Scott Obach, Larry M. Tremaine

    Published in Drug metabolism and disposition (01-09-2008)
    “…Cytochrome P450 induction-mediated drug-drug interaction (DDI) is one of the major concerns in clinical practice and for the pharmaceutical industry…”
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