Search Results - "Boldt, Karsten"

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles by Volz, Ann-Kathrin, Frei, Alina, Kretschmer, Viola, de Jesus Domingues, António M., Ketting, Rene F., Ueffing, Marius, Boldt, Karsten, Krämer-Albers, Eva-Maria, May-Simera, Helen L.

“…Primary cilia are microtubule based sensory organelles important for receiving and processing cellular signals. Recent studies have shown that cilia also…”
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Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro by Gloeckner, Christian Johannes, Schumacher, Annette, Boldt, Karsten, Ueffing, Marius

“…Autosomal dominant mutations in the human Leucine-Rich Repeat Kinase 2 (LRRK2) gene represent the most common monogenetic cause of Parkinson disease (PD) and…”
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Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation by Charitou, Theodosia, Srihari, Sriganesh, Lynn, Miriam A., Jarboui, Mohamed-Ali, Fasterius, Erik, Moldovan, Max, Shirasawa, Senji, Tsunoda, Toshiyuki, Ueffing, Marius, Xie, Jianling, Xin, Jin, Wang, Xuemin, Proud, Christopher G., Boldt, Karsten, Al-Khalili Szigyarto, Cristina, Kolch, Walter, Lynn, David J.

“…Background Activating mutations in KRAS frequently occur in colorectal cancer (CRC) patients, leading to resistance to EGFR-targeted therapies. Methods To…”
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The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium by Ying, Guoxin, Boldt, Karsten, Ueffing, Marius, Gerstner, Cecilia D., Frederick, Jeanne M., Baehr, Wolfgang

“…RAB28, a member of the RAS oncogene family, is a ubiquitous, farnesylated, small GTPase of unknown function present in photoreceptors and the retinal pigmented…”
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Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts by Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes

“…Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase…”
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CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement by Beyer, Tina, Bolz, Sylvia, Junger, Katrin, Horn, Nicola, Moniruzzaman, Muhammad, Wissinger, Yasmin, Ueffing, Marius, Boldt, Karsten

“…CRISPR/Cas9-mediated gene editing allows manipulation of a gene of interest in its own chromosomal context. When applied to the analysis of protein…”
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The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development by Beckers, Anja, Adis, Christian, Schuster-Gossler, Karin, Tveriakhina, Lena, Ott, Tim, Fuhl, Franziska, Hegermann, Jan, Boldt, Karsten, Serth, Katrin, Rachev, Ev, Alten, Leonie, Kremmer, Elisabeth, Ueffing, Marius, Blum, Martin, Gossler, Achim

“…Cilia are complex cellular protrusions consisting of hundreds of proteins. Defects in ciliary structure and function, many of which have not been characterised…”
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Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1 by Szymanska, Katarzyna, Boldt, Karsten, Logan, Clare V, Adams, Matthew, Robinson, Philip A, Ueffing, Marius, Zeqiraj, Elton, Wheway, Gabrielle, Johnson, Colin A

“…Primary ciliary defects cause a group of developmental conditions known as ciliopathies. Here, we provide mechanistic insight into ciliary ubiquitin processing…”
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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool by Piccoli, Giovanni, Condliffe, Steven B, Bauer, Matthias, Giesert, Florian, Boldt, Karsten, De Astis, Silvia, Meixner, Andrea, Sarioglu, Hakan, Vogt-Weisenhorn, Daniela M, Wurst, Wolfgang, Gloeckner, Christian Johannes, Matteoli, Michela, Sala, Carlo, Ueffing, Marius

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in…”
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The Na+-activated K+ channel Slack contributes to synaptic development and plasticity by Matt, Lucas, Pham, Thomas, Skrabak, David, Hoffmann, Felix, Eckert, Philipp, Yin, Jiaqi, Gisevius, Miriam, Ehinger, Rebekka, Bausch, Anne, Ueffing, Marius, Boldt, Karsten, Ruth, Peter, Lukowski, Robert

“…Human mutations of the Na + -activated K + channel Slack ( KCNT1 ) are associated with epilepsy and intellectual disability. Accordingly, Slack knockout mice (…”
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The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus by Beckers, Anja, Fuhl, Franziska, Ott, Tim, Boldt, Karsten, Brislinger, Magdalena Maria, Walentek, Peter, Schuster-Gossler, Karin, Hegermann, Jan, Alten, Leonie, Kremmer, Elisabeth, Przykopanski, Adina, Serth, Katrin, Ueffing, Marius, Blum, Martin, Gossler, Achim

“…Cilia are protrusions of the cell surface and composed of hundreds of proteins many of which are evolutionary and functionally well conserved. In cells…”
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Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye by Thompson, Richard B., Reffatto, Valentina, Bundy, Jacob G., Kortvely, Elod, Flinn, Jane M., Lanzirotti, Antonio, Jones, Emrys A., McPhail, David S., Fearn, Sarah, Boldt, Karsten, Ueffing, Marius, Ratu, Savanjeet Guy Singh, Pauleikhoff, Laurenz, Bird, Alan C., Lengyel, Imre

“…Significance Proteins and lipids accumulating in deposits external to the retinal pigment epithelium (RPE) represent a barrier to metabolic exchange between…”
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Affinity Proteomics Identifies Interaction Partners and Defines Novel Insights into the Function of the Adhesion GPCR VLGR1/ADGRV1 by Knapp, Barbara, Roedig, Jens, Roedig, Heiko, Krzysko, Jacek, Horn, Nicola, Güler, Baran E, Kusuluri, Deva Krupakar, Yildirim, Adem, Boldt, Karsten, Ueffing, Marius, Liebscher, Ines, Wolfrum, Uwe

“…The very large G-protein-coupled receptor 1 (VLGR1/ADGRV1) is the largest member of the adhesion G-protein-coupled receptor (ADGR) family. Mutations in…”
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Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis by Bakhti, Mostafa, Bastidas-Ponce, Aimée, Tritschler, Sophie, Czarnecki, Oliver, Tarquis-Medina, Marta, Nedvedova, Eva, Jaki, Jessica, Willmann, Stefanie J., Scheibner, Katharina, Cota, Perla, Salinno, Ciro, Boldt, Karsten, Horn, Nicola, Ueffing, Marius, Burtscher, Ingo, Theis, Fabian J., Coskun, Ünal, Lickert, Heiko

“…During pancreas development endocrine cells leave the ductal epithelium to form the islets of Langerhans, but the morphogenetic mechanisms are incompletely…”
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Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2 by Gloeckner, Christian Johannes, Boldt, Karsten, von Zweydorf, Felix, Helm, Sandra, Wiesent, Ludwig, Sarioglu, Hakan, Ueffing, Marius

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) that increase its kinase activity associate with familial forms of Parkinson disease (PD). As phosphorylation…”
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Activity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo by Schuster-Gossler, Karin, Boldt, Karsten, Bornhorst, Dorothee, Delany-Heiken, Patricia, Ueffing, Marius, Gossler, Achim

“…Abstract Objective The mammalian Notch ligand DLL1 has essential functions during development. To visualise DLL1 in tissues, for sorting and enrichment of…”
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Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry by Kinzel, Doris, Boldt, Karsten, Davis, Erica E., Burtscher, Ingo, Trümbach, Dietrich, Diplas, Bill, Attié-Bitach, Tania, Wurst, Wolfgang, Katsanis, Nicholas, Ueffing, Marius, Lickert, Heiko

“…A variety of developmental disorders have been associated with ciliary defects, yet the controls that govern cilia disassembly are largely unknown. Here we…”
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The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice by Beckers, Anja, Ott, Tim, Schuster-Gossler, Karin, Boldt, Karsten, Alten, Leonie, Ueffing, Marius, Blum, Martin, Gossler, Achim

“…The transcription factor FOXJ1 is essential for the formation of motile cilia throughout the animal kingdom. Target genes therefore likely constitute an…”
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The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking by Bachmann-Gagescu, Ruxandra, Dona, Margo, Hetterschijt, Lisette, Tonnaer, Edith, Peters, Theo, de Vrieze, Erik, Mans, Dorus A, van Beersum, Sylvia E C, Phelps, Ian G, Arts, Heleen H, Keunen, Jan E, Ueffing, Marius, Roepman, Ronald, Boldt, Karsten, Doherty, Dan, Moens, Cecilia B, Neuhauss, Stephan C F, Kremer, Hannie, van Wijk, Erwin

“…Ciliopathies are a group of human disorders caused by dysfunction of primary cilia, ubiquitous microtubule-based organelles involved in transduction of…”
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A QUICK Screen for Lrrk2 Interaction Partners – Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics by Meixner, Andrea, Boldt, Karsten, Van Troys, Marleen, Askenazi, Manor, Gloeckner, Christian J., Bauer, Matthias, Marto, Jarrod A., Ampe, Christophe, Kinkl, Norbert, Ueffing, Marius

“…Mutations in human leucine-rich repeat kinase 2 (Lrrk2), a protein of yet unknown function, are linked to Parkinson's disease caused by degeneration of…”
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