Search Results - "Boldogh, I."

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model by Tanner, L., Single, A. B., Bhongir, R. K. V., Heusel, M., Mohanty, T., Karlsson, C. A. Q., Pan, L., Clausson, C-M., Bergwik, J., Wang, K., Andersson, C. K., Oommen, R. M., Erjefält, J. S., Malmström, J., Wallner, O., Boldogh, I., Helleday, T., Kalderén, C., Egesten, A.

“…Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by…”
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The redox-associated adaptive response of brain to physical exercise by Radak, Z, Ihasz, F, Koltai, E, Goto, S, Taylor, A W, Boldogh, I

“…Reactive oxygen species (ROS) are continuously generated during metabolism. ROS are involved in redox signaling, but in significant concentrations they can…”
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Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair by Sarga, L, Hart, N, Koch, L.G, Britton, S.L, Hajas, G, Boldogh, I, Ba, X, Radak, Z

“…Graphical abstract…”
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Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution by Ray, Sutapa, Lee, Chang, Hou, Tieying, Boldogh, Istvan, Brasier, Allan R

“…Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor that plays a crucial role in interleukin-6 (IL-6) signaling, mediating the…”
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IL-8 And Neutrophils In Bronchoalveolar Lavage Fluids Distinguish Mild Asthma From Moderate To Severe Asthma by Sur, S, Ying, S, Corrigan, C, Kurosky, A, Boldogh, I, Qi, H

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In vivo Exposure to Alternaria Induces Danger Cytokine Release in Airway that Drive Th2 Differentiation and Allergic Inflammation to Bystander Antigens by Qi, H, Murai, H, Boldogh, I, Sur, S

“…Bone marrow derived CD11c+ dentritic cells (BMDCs), naïve CD4+ T cells and bystander antigen Amb a 1 were cultured with these BALF to induce differentiation,…”
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hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs by Boldogh, I, Milligan, D, Lee, M S, Bassett, H, Lloyd, R S, McCullough, A K

“…The human MutY homolog, hMYH, is an adenine-specific DNA glycosylase that removes adenines or 2-hydroxyadenines mispaired with guanines or 8-oxoguanines. In…”
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Challenge With Ragweed Pollen Extract (RWPE) In Allergic Rhinitis Induces Rapid Increase In 8-hydroxydeoxyguanosine (8-OHdG), IL-10 and G-CSF by Qi, H, Redding, D, Kurosky, A, Singh, B, Lane, J, Bain, M, Boldogh, I, Hazra, T, Sur, S

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Alternaria Extract Rapidly And Specifically Induces Th2 Differentiation-inducing Cytokine From Normal Human Bronchial Epithelial Cells by Murai, H, Qi, H, Kalita, A, Kurosky, A, Boldogh, I, Sur, S

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Endoplasmic reticulum dynamics, inheritance, and cytoskeletal interactions in budding yeast by Fehrenbacher, K L, Davis, D, Wu, M, Boldogh, I, Pon, Liza A

“…The endoplasmic reticulum (ER) in Saccharomyces cerevisiae consists of a reticulum underlying the plasma membrane (cortical ER) and ER associated with the…”
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NADPH Oxidase In Ragweed Pollen Promotes Th2 Differentiation Of Naïve T-cells And Induces IL-33 Secretion From BMDCs Via TLR4 And MYD88 Dependent Pathways by Kalita, A, Qi, H, Murai, H, Kurosky, A, Boldogh, I, Hazra, T, Corry, D, Sur, S

“…Here, we examined the contribution of innate immune pathways utilized by pollen NADPH oxidases to promote secretion of IL33, a TH2 differentiation-inducing…”
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Alternaria Activates cSrc -Cathepsin K Danger Pathway-dependent Release Of Pro-inflammatory Cytokines From Airway Epithelial Cells by Murai, H, Qi, H, Vaidya, S, Kurosky, A, Boldogh, I, Sur, S

“…Alternaria extract induces necrosis of epithelial cells and release of HMGB1 and IL-18 by activating a novel cSrc-cathepsin K signaling pathway. Because IL-18…”
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Ragweeds Extract (RWE) Proteins That Lack NADPH Oxidase Activity (RWENOX-) Promote Th1 Response By Upregulating CD40 Expression Independent of MAP Kinases by Kalita, A, Vaidya, S, Murai, H, Stafford, S, Kurosky, A, Boldogh, I, Hazra, T, Sur, S

“…RWENOX- increases CD123 expression via MEK-ERK and P38 MAPK pathways, and promotes Th1 response. Because CD40 ligation has been shown to trigger IL12…”
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Genes Involved in the Allergic Airway Inflammation Induced by Ragweed Extract (RWE) Associated NADPH Oxidase by Vaidya, S, Singh, B, Dharajiya, N, Sinha, M, Boldogh, I, Sur, S

“…Surprisingly, these genes were not downregulated by co-administration of NAC with RWE, and in case of Ccl11, Ccl17 and Ccl22, were upregulated. Since this was…”
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Oxidative Damage to Mitochondrial Respiratory Chain Complexes Increases Allergic Airway Inflammation in Mice by Aguilera-Aguirre, L, Saavedra-Molina, A, Bacsi, A, Sur, S, Boldogh, I

“…Exposure of A549 human airway epithelial cells to RWE induced oxidative damage to MRC proteins NADH dehydrogenase (ubiquinone) Fe-S protein (NDUFS) 1, NDUFS2,…”
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Antigen-independent Mitochondria-driven Release of Biogenic Amines from RBL-2H3 Cells by Bacsi, A, Chodaczek, G, Dharajiya, N, Sur, S, Hazra, T.K, Boldogh, I

“…The underlying mechanism involves migration of secretory granules to the cytoplasmic membrane without complete fusion, activation of protein kinase C-delta,…”
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Pollen-grain-induced Oxidative Stress Activates Dendritic Cells by Csillag, A, Boldogh, I, Pazmandi, K, Magyarics, Z, Rajnavolgyi, E, Bacsi, A

“…Pollen-derived ROS may contribute to local innate immunity by triggering proinflammatory cytokine production of DCs. [...]pollen-produced ROS affect the…”
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New insights into clinical trial for colostrinin™ in Alzheimer’s disease by Szaniszlo, P., German, P., Hajas, G., Saenz, D. N., Kruzel, M., Boldogh, I.

“…Background The pathomechanism of Alzheimer’s disease (AD) is multifactorial although the most popular hypotheses are centered on the effects of the misfolded,…”
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Topical N-acetyl cysteine (NAC) Reduces Late Phase Nasal Symptoms Following Ragweed Challenge by Lane, C.J, Redding, D.R, Gonzalez, K.A, Cardenas, V.J, Boldogh, I, Sur, S

“…Ragweed sensitive patients were identified using skin prick testing and underwent nasal provocation challenges with either saline or ragweed extract (RWE.)…”
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Identification of Biomarkers in Nasal Lavage Fluid (NLF) Associated with Early and Late Phase Symptoms Induced by Intranasal Challenge with Ragweed Extract (RWE) by Qi, H, Redding, D, Kurosky, A, Singh, B, Boldogh, I, Soman, K, Grant, J.A, Cardenas, V, Sur, S

“…Intrinsic NADPH oxidases in RWE induce ROS in airway epithelium of mice and augment RWE-induced allergic airway inflammation…”
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