Search Results - "Boldizsar, Noelia"

G protein‐coupled receptor kinases regulate &[beta]‐arrestin interactions with the D2 dopamine receptor in an isoform‐specific manner and in the absence of direct receptor phosphorylation by Boldizsar, Noelia M., Sanchez‐Soto, Marta, Schardien, Kayla, Drube, Julia, Haider, Raphael, Free, R. B., Hoffmann, Carsten, Sibley, David

“…The D2 dopamine receptor (D2R) regulates numerous CNS functions including movement, cognition, emotion, and reward circuitry. Agonist binding to the D2R…”
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Location bias contributes to functionally selective responses of biased CXCR3 agonists by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Pham, Uyen, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey S., Zhang, Jennifer Y., Rajagopal, Sudarshan

“…Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially activate specific signaling transducers over others. Although GPCRs…”
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G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation by Sánchez-Soto, Marta, Boldizsar, Noelia M., Schardien, Kayla A., Madaras, Nora S., Willette, Blair K. A., Inbody, Laura R., Dasaro, Christopher, Moritz, Amy E., Drube, Julia, Haider, Raphael S., Free, R. Benjamin, Hoffman, Carsten, Sibley, David R.

“…The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward…”
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Identification and Characterization of ML321: A Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity by Free, R. Benjamin, Nilson, Ashley N., Boldizsar, Noelia M., Doyle, Trevor B., Rodriguiz, Ramona M., Pogorelov, Vladimir M., Machino, Mayako, Lee, Kuo Hao, Bertz, Jeremiah W., Xu, Jinbin, Lim, Herman D., Dulcey, Andrés E., Mach, Robert H., Woods, James H., Lane, J Robert, Shi, Lei, Marugan, Juan J., Wetsel, William C., Sibley, David R.

“…We have developed and characterized a novel D2R antagonist with exceptional GPCR selectivity – ML321. In functional profiling screens of 168 different GPCRs,…”
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Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity by Free, R Benjamin, Nilson, Ashley N, Boldizsar, Noelia M, Doyle, Trevor B, Rodriguiz, Ramona M, Pogorelov, Vladimir M, Machino, Mayako, Lee, Kuo Hao, Bertz, Jeremiah W, Xu, Jinbin, Lim, Herman D, Dulcey, Andrés E, Mach, Robert H, Woods, James H, Lane, J Robert, Shi, Lei, Marugan, Juan J, Wetsel, William C, Sibley, David R

“…We have developed and characterized a novel D2R antagonist with exceptional GPCR selectivity - ML321. In functional profiling screens of 168 different GPCRs,…”
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Biased agonism at chemokine receptors by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Rajagopal, Sudarshan

“…In the human chemokine system, interactions between the approximately 50 known endogenous chemokine ligands and 20 known chemokine receptors (CKRs) regulate a…”
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Sympathetic and Parasympathetic Regulation of NF‐κB by GPCRs through the modulation of interactions between p65/RelA and the β‐arrestins by Honeycutt, Christopher, Eiger, Dylan, Boldizsar, Noelia, Gardner, Julia, Rajagopal, Sudarshan

“…Study Objective: This project sought to elucidate the biological mechanisms and physiological significance of β2 adrenergic receptor (B2AR)‐ and M1 muscarinic…”
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Receptor Endocytosis as a Mechanism of Biased Agonism at CXCR3 by Boldizsar, Noelia, Eiger, Dylan, Honeycutt, Cole, Gardner, Julia, Rajagopal, Sudarshan

“…G Protein Coupled Receptors (GPCRs) are the largest class of receptors in the human genome. They are expressed in virtually every cell type and are implicated…”
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Differential GRK Recruitment and the Phosphorylation Barcode as a Mechanism for Biased Agonism at G Protein‐Coupled Receptors by Gardner, Julia, Eiger, Dylan, Honeycutt, Christopher, Boldizsar, Noelia, Choi, Issac, Rajagopal, Sudarshan

“…G Protein‐Coupled Receptors (GPCRs) are the largest and most diverse family of cell receptors in the human genome and account for ~30% of all FDA‐approved…”
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Location Bias of G Protein‐Coupled Receptor Kinases Promotes Biased Signaling at CXCR3 by Hicks, Chloe N., Eiger, Dylan, Gardner, Julia, Boldizsar, Noelia, Honeycutt, Cole, Choi, Issac, Rajagopal, Sudarshan

“…G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors and are known to canonically signal through two main effector proteins: G…”
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Location Bias Contributes to Functionally Selective Responses of Biased CXCR3 Agonists to Regulate Inflammation by Gardner, Julia, Eiger, Dylan, Boldizsar, Noelia, Honeycutt, Christopher C., Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey, Zhang, Jennifer, Rajagopal, Sudarshan

“…G Protein‐Coupled Receptors (GPCRs) represent the largest and most diverse family of cell receptors in the human genome and are targeted by ~35% of all…”
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Phosphorylation barcodes direct biased chemokine signaling at CXCR3 by Eiger, Dylan S, Smith, Jeffrey S, Shi, Tujin, Stepniewski, Tomasz Maciej, Tsai, Chia-Feng, Honeycutt, Christopher, Boldizsar, Noelia, Gardner, Julia, Nicora, Carrie D, Moghieb, Ahmed M, Kawakami, Kouki, Choi, Issac, Hicks, Chloe, Zheng, Kevin, Warman, Anmol, Alagesan, Priya, Knape, Nicole M, Huang, Ouwen, Silverman, Justin D, Smith, Richard D, Inoue, Asuka, Selent, Jana, Jacobs, Jon M, Rajagopal, Sudarshan

“…G protein-coupled receptor (GPCR)-biased agonism, selective activation of certain signaling pathways relative to others, is thought to be directed by…”
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Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα i :β-arrestin complexes by Zheng, Kevin, Smith, Jeffrey S, Eiger, Dylan S, Warman, Anmol, Choi, Issac, Honeycutt, Christopher C, Boldizsar, Noelia, Gundry, Jaimee N, Pack, Thomas F, Inoue, Asuka, Caron, Marc G, Rajagopal, Sudarshan

“…G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and signal through the proximal effectors, G proteins and β-arrestins, to…”
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Characterization and Chemical Optimization of the D2 Dopamine Receptor‐Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders by Nilson, Ashley N., Dulcey Garcia, Andres, Free, R. B., Boldizsar, Noelia, Pearlstein, Hannah, Rocereta, Julia A., Rodriguiz, Ramona M., Lane, J. R., Lee, Kuo H., Shi, Lei, Wetsel, William C., Marugan, Juan J., Sibley, David R.

“…Schizophrenia is a devastating illness characterized by both positive (hallucinations, delusions) and negative (flat affect, decreased motivation) symptoms…”
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Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non‐redundant chemokine signaling by Eiger, Dylan S., Smith, Jeffrey, Shi, Tujin, Stepniewski, Tomasz M., Honeycutt, Christopher, Boldizsar, Noelia, Gardner, Julia, Tsai, Chia‐Feng, Nicora, Carrie, Moghieb, Ahmed, Kawakami, Kouki, Choi, Issac, Smith, Richard, Inoue, Asuka, Selent, Jana, Jacobs, Jon, Rajagopal, Sudarshan

“…Chemokine receptors, a group of G protein‐coupled receptors (GPCRs), interact with transducers such as G proteins, β‐arrestins, and GPCR kinases (GRKs). In the…”
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Novel Dopamine D4 Receptor‐Selective Antagonists For Neuropsychiatric Disorders by Keck, Thomas M., Kelshikar, Shreya, Shah, Nisha, McBride, Connor, Ximello Sanchez, Moises, Panasis, Diandra, Maslonka, Brianna, Muccilli, Abigail, Ladik, Maria, Akca, Ebrar, Ginet, Sophia, Nilson, Ashley, Boldizsar, Noelia, Free, R. Benjamin, Sibley, David R., Boateng, Comfort A.

“…The neurotransmitter dopamine signals through G protein‐coupled receptors that regulate a variety of neurophysiological functions, including movement,…”
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Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder by Boateng, Comfort A., Nilson, Ashley N., Placide, Rebekah, Pham, Mimi L., Jakobs, Franziska M., Boldizsar, Noelia, McIntosh, Scot, Stallings, Leia S., Korankyi, Ivana V., Kelshikar, Shreya, Shah, Nisha, Panasis, Diandra, Muccilli, Abigail, Ladik, Maria, Maslonka, Brianna, McBride, Connor, Sanchez, Moises Ximello, Akca, Ebrar, Alkhatib, Mohammad, Saez, Julianna, Nguyen, Catherine, Kurtyan, Emily, DePierro, Jacquelyn, Crowthers, Raymond, Brunt, Dylan, Bonifazi, Alessandro, Newman, Amy Hauck, Rais, Rana, Slusher, Barbara S., Free, R. Benjamin, Sibley, David R., Stewart, Kent D., Wu, Chun, Hemby, Scott E., Keck, Thomas M.

“…Pharmacological targeting of the dopamine D4 receptor (D4R)expressed in brain regions that control cognition, attention, and decision-makingcould be useful…”
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G Protein-Coupled Receptor Kinase 2 Selectively Enhances beta-Arrestin Recruitment to the D[sub.2] Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation by Sanchez-Soto, Marta, Boldizsar, Noelia M, Schardien, Kayla A, Madaras, Nora S, Willette, Blair K. A, Inbody, Laura R, Dasaro, Christopher, Moritz, Amy E, Drube, Julia, Haider, Raphael S, Free, R. Benjamin, Hoffman, Carsten, Sibley, David R

“…The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward…”
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G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D 2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation by Sánchez-Soto, Marta, Boldizsar, Noelia M, Schardien, Kayla A, Madaras, Nora S, Willette, Blair K A, Inbody, Laura R, Dasaro, Christopher, Moritz, Amy E, Drube, Julia, Haider, Raphael S, Free, R Benjamin, Hoffman, Carsten, Sibley, David R

“…The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward…”
Get full text