Search Results - "Bold, P"

Application of Lithiation–Borylation to the Total Synthesis of (−)-Rakicidin F by Bold, Christian P., Yeung, Kay, Pape, Felix, Kaiser, Daniel, Aggarwal, Varinder K.

“…The stereochemistry of the lipophilic side chain of (+)-rakicidin F had not been determined until recently. Using our lithiation–borylation methodology…”
Get full text

Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines by Abell, Joseph C., Bold, Christian P., Vicens, Laia, Jentsch, Tom, Velasco, Noelia, Tyler, Jasper L., Straker, Robert N., Noble, Adam, Aggarwal, Varinder K.

“…The identification of the beneficial pharmacokinetic properties of aza-spirocycles has led to the routine incorporation of these highly rigid and…”
Get full text

Studies toward the Synthesis of an Oxazole-Based Analog of (−)-Zampanolide by Bold, Christian P, Klaus, Cindy, Pfeiffer, Bernhard, Schürmann, Jasmine, Lombardi, Rafael, Lucena-Agell, Daniel, Díaz, J. Fernando, Altmann, Karl-Heinz

“…Studies are described toward the synthesis of an oxazole-based analog of (−)-zampanolide (2). Construction of (−)-dactylolide analog 22 was achieved via…”
Get full text

Fatigue crack growth rates under sequential mixed-mode I and II loading cycles by Wong, S. L., Bold, P. E., Brown, M. W., Allen, R. J.

“…One common mode of failure that occurs in rolling bodies such as gears, bearings and rails is due to the fatigue process. Several research workers suggest that…”
Get full text

A branch criterion for shallow angled rolling contact fatigue cracks in rails by Wong, S.L., Bold, P.E., Brown, M.W., Allen, R.J.

“…A well-developed ‘squat’ grows at about 10° to the upper surface of the rail. It is observed that this shallow angled rolling contact fatigue crack may change…”
Get full text

Synthesis of Photoswitchable Δ 9 -Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling by Westphal, Matthias V, Schafroth, Michael A, Sarott, Roman C, Imhof, Michael A, Bold, Christian P, Leippe, Philipp, Dhopeshwarkar, Amey, Grandner, Jessica M, Katritch, Vsevolod, Mackie, Ken, Trauner, Dirk, Carreira, Erick M, Frank, James A

“…The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and…”
Get full text

Two measurement techniques for determining effective stress intensity factors by Wong, S. L., Bold, P. E., Brown, M. W., Allen, R. J.

“…Two methods were studied for determining crack closure and locking effects under combinations of mixed mode I and II loading, namely the strain gauge and the…”
Get full text

The chemistry of disorazoles and structure-activity relationships: An update by Bold, Christian P., Altmann, Karl-Heinz

“…The disorazoles are a family of 26- to 32-membered macrodiolides of mixed non-ribosomal peptide and polyketide origin that show exceptional cytotoxic activity…”
Get full text

D101 ALLERGY AND ASTHMA: NOVEL REGULATORY PATHWAYS: Lung-Targeted Dual Pi3k[gamma][delta] Inhibition: Evidence For A Novel Therapeutic Strategy For Multiple Severe Asthma Phenotypes by Thomas, M, Bold, P, Bjorhall, K, Butcher, A, Carlsson, J F, Cygan, P, Karlsson, M, Lindmark, H, Perry, M, Mogemark, M, Morrisson, V, Norberg, M, Blomqvist, S Rodrigo, Goodyear, C, Karabelas, K

Get full text

C31 EXPERIMENTAL ASTHMA THERAPIES: In Vivo Dual Pi3k[gamma][delta] Inhibition In A Rat Model Of Pulmonary Inflammation - Evidence Of Local Therapeutic Activity by Blomqvist, S R, Andreasson, T, Arlbrandt, S, Bold, P, Bjorhall, K, Brülls, M, Cygan, P, Karlsson, M, Mogemark, M, Perry, M, Morrison, V, Goodyear, C, Karabelas, K, Thomas, M

Get full text

C35 INNATE IMMUNE MECHANISMS IN COPD: Highly Selective Inhibitors Of Pi3k[gamma] For The Oral Treatment Of COPD by Karabelas, K, Arlbrandt, S, Bold, P, Butcher, A, Carlsson, J F, Cygan, P, Ehnebom, J, Goodyear, C, MacLellan, L, Nordberg, M, Lindmark, H, Mogemark, M, Pehrson, R, Perry, M, Blomqvist, S R, Stern, A, Thomas, M

Get full text

A screening method for the rapid detection of barbiturates in serum by means of tandem mass spectrometry by Brzezinka, H, Bold, P, Budzikiewicz, H

“…A mass spectrometric screening method for barbiturates in serum was developed. Under electron impact conditions barbiturates fragment by loss of HNCO. A…”
Get more information

Synthesis of Photoswitchable Δ9‑Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling by Westphal, Matthias V, Schafroth, Michael A, Sarott, Roman C, Imhof, Michael A, Bold, Christian P, Leippe, Philipp, Dhopeshwarkar, Amey, Grandner, Jessica M, Katritch, Vsevolod, Mackie, Ken, Trauner, Dirk, Carreira, Erick M, Frank, James A

“…The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and…”
Get full text

Direct identification of major histocompatibility complex class I-bound tumor-associated peptide antigens of a renal carcinoma cell line by a novel mass spectrometric method by FLAD, T, SPENGLER, B, KURZ, B, MÜLLER, C. A, KALBACHER, H, BROSSART, P, BAIER, D, KAUFMANN, R, BOLD, P, METZGER, S, BLÜGGEL, M, MEYER, H. E

“…Melanoma and renal cell carcinoma (RCC) are thought to be the most immunogenic human tumors. Presently a series of tumor-specific peptides of melanoma is being…”
Get full text

A screening method for rapid detection of barbiturates in serum using tandem mass spectrometry by Bold, P, Brzezinka, H, Budzikiewicz, H

“…A mass spectrometric screening method for the detection of barbiturates in serum will be presented. Fragmentation of barbiturates under EI conditions leads to…”
Get more information

Multiaxial fatigue crack growth in rail steel by Bold, P E

“…In the introduction to a recent symposium on rolling contact fatigue, R.A.Smith stated that it was difficult to apply our greatly increased understanding of…”
Get full text

Time is muscle. The Cape Cod Chest Pain Task Force helps shorten AMI discovery-to-treatment times by Bold, S P, Luedtke, G

Get more information

Driver hand position on the steering wheel while merging into motorway traffic by De Waard, Dick, Van den Bold, Thigri G.M.P.R., Lewis-Evans, Ben

“…It has been suggested that a driver’s hand position on the steering wheel can reflect the perceived risk of the road context (Walton, D., & Thomas, J. A…”
Get full text

Pyruvate kinase activity in the lymphocytes of malnourished, anergic patients by Wren, S F, Crowe, M, Lowe, P J, de Bold, P J

Get more information