Search Results - "Bolaffi, J L"

The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract by Goldfine, Ira D, German, Michael S, Tseng, Hsien-Chen, Wang, Juemin, Bolaffi, Janice L, Chen, Je-Wei, Olson, David C, Rothman, Stephen S

“…The exocrine pancreas, liver, and submandibular glands of the rat were used to express and secrete two exogenous, human protein hormones (growth hormone and…”
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Differences in insulin secretion between the rat and mouse: role of cAMP by Ma, Y H, Wang, J, Rodd, G G, Bolaffi, J L, Grodsky, G M

“…Although information regarding insulin secretion usually is considered equivalent when generated in the mouse or the rat, it is established that the kinetics…”
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Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta by Bolaffi, J L, Rodd, G G, Wang, J, Grodsky, G M

“…Complete loss of pancreatic insulin function in insulin-dependent diabetes is thought to be due to an autoimmune cytokine-mediated destruction of the…”
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Direct effects of glucose on proinsulin synthesis and processing during desensitization by Nagamatsu, S, Bolaffi, J L, Grodsky, G M

“…Prolonged exposure of isolated islets to glucose (11 mM) results in desensitization of insulin secretion. In this study, both glucose-regulated proinsulin…”
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Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion by Bolaffi, J L, Nagamatsu, S, Harris, J, Grodsky, G M

“…It has been suggested that a result of streptozotocin (Sz)-initiated damage to beta-cell DNA is activation of the repair enzyme nuclear poly-ADP-ribose…”
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Desensitization of the insulin-secreting beta cell by Grodsky, G M, Bolaffi, J L

“…In human diabetes, inherent impaired insulin secretion can be exacerbated by desensitization of the beta cell by chronic hyperglycemia. Interest in this…”
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The third phase of in vitro insulin secretion: evidence for glucose insensitivity by BOLAFFI, J. L, HELDT, A, LEWIS, L. D, GRODSKY, G. M

“…In this study, in vitro B-cell models are described, which may be applicable for studying the reported B-cell desensitization produced by hyperglycemia in IDDM…”
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Progressive damage of cultured pancreatic islets after single early exposure to streptozocin by BOLAFFI, J. L, NOWLAIN, R. E, CRUZ, L, GRODSKY, G. M

“…To examine effects of streptozocin (STZ) on pancreatic islets in the absence of a functioning immune system, we examined isolated rat islets cultured for 96 h…”
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Progressive damage of cultured pancreatic islets after single early exposure to streptozocin by Bolaffi, J. L., Nowlain, R. E., Cruz, L., Grodsky, G. M.

“…Progressive damage of cultured pancreatic islets after single early exposure to streptozocin. J L Bolaffi , R E Nowlain , L Cruz and G M Grodsky Abstract To…”
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Effect of glucagon or somatostatin on desensitized insulin secretion by Bolaffi, J L, Rodd, G, Ma, Y H, Grodsky, G M

“…In this study we have examined the role of glucagon and somatostatin in regulating glucose-induced desensitization of insulin secretion from rat islets…”
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Thyrotropin-releasing hormone (TRH): immunohistochemical distribution in tadpole and frog brain by Mimnagh, K M, Bolaffi, J L, Montgomery, N M, Kaltenbach, J C

“…The anatomical localization of immunoreactive TRH (IR-TRH) was demonstrated by the peroxidase-antiperoxidase technique in the brain and pituitary gland of…”
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The third phase of in vitro insulin secretion. Evidence for glucose insensitivity by Bolaffi, J. L., Heldt, A., Lewis, L. D., Grodsky, G. M.

“…The third phase of in vitro insulin secretion. Evidence for glucose insensitivity. J L Bolaffi , A Heldt , L D Lewis and G M Grodsky Abstract In this study, in…”
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Characteristics of desensitization of insulin secretion in fully in vitro systems by Bolaffi, J L, Bruno, L, Heldt, A, Grodsky, G M

“…This report has investigated desensitization of pancreatic B cell secretion, or diminution of the insulin response to chronic stimulation. Freshly isolated rat…”
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The role of Ca(2+)-related events in glucose-stimulated desensitization of insulin secretion by Bolaffi, J L, Rodd, G G, Ma, Y H, Bright, D, Grodsky, G M

“…The spontaneous decline of insulin secretion (third phase) that occurs under a variety of secretory conditions is well documented and suggests a general…”
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Characterisation of somatostatin and TRH release by rat hypothalamic and cerebral cortical neurons maintained on a capillary membrane perfusion system by Scanlon, M F, Robbins, R J, Bolaffi, J L, Jackson, I M, Reichlin, S

“…We have investigated the nature of the immunoreactive somatostatin (SS) and thyrotropin-releasing hormone (TRH) produced by long-term capillary perfusion…”
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Induced metamorphosis in Ambystoma mexicanum: lack of effect of triiodothyronine on tissue or blood levels of thyrotropin-releasing hormone (TRH) by Sawin, C T, Bolaffi, J L, Callard, I P, Bacharach, P, Jackson, I M

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Opposite, phase-dependent effects of 3,4,5-trimethoxybenzoic acid 8-(diethylamino) octyl ester or tetracaine on islet function during three phases of glucose-stimulated insulin secretion by Bolaffi, J L, Rodd, G G, Ma, Y H, Grodsky, G M

“…The spontaneous decline of insulin secretion which occurs under a variety of secretory conditions is well documented and suggests a general desensitization of…”
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Identification of 11-ketotestosterone, 11 beta-hydroxytestosterone, and testosterone in plasma of Necturus maculosus (Rafinesque) by Bolaffi, J L, Lance, V, Callard, I P, Walsh, J M, Idler, D R

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Some characteristics of chemically-induced beta-cell lesions as possible contributing factors in diabetes by Grodsky, G M, Bolaffi, J L

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TRH stimulation of in vivo GH release in the domestic fowl. Influence of TRH metabolites and effect of age on in vitro degradation of TRH by Scanes, C G, Harvey, S, Bolaffi, J L

“…Thyrotropin-releasing hormone (TRH) stimulated in vivo growth hormone (GH) release in conscious and anesthetized young domestic fowl. The administration of the…”
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