Search Results - "Bolaños, J P"

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway by Jimenez-Blasco, D, Santofimia-Castaño, P, Gonzalez, A, Almeida, A, Bolaños, J P

“…Neurotransmission unavoidably increases mitochondrial reactive oxygen species. However, the intrinsic antioxidant defense of neurons is weak and hence the…”
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Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration by Rodriguez-Rodriguez, P, Fernandez, E, Almeida, A, Bolaños, J P

“…6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a master regulator of glycolysis by its ability to synthesize fructose-2,6-bisphosphate, a…”
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IDENTIFICATION AND CHARACTERIZATION OF THE FOYER OF THE NATIONAL THEATER OF COSTA RICA AS PART OF THE METHODOLOGICAL STRATEGY FOR THE THREE-DIMENSIONAL MODELING OF THE FUTURE DIGITAL TWIN by Hernández-Salazar, I., Bulgarelli-Bolaños, J. P.

“…This paper summarizes the first results of the third specific objective of the research project: Digital Twin (DT) as a management tool for the programmed…”
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Retinoic acid downregulates Rae1 leading to APC activation and neuroblastoma SH-SY5Y differentiation by Cuende, J, Moreno, S, Bolaños, J P, Almeida, A

“…In neuroblastoma cells, retinoic acid induces cell cycle arrest and differentiation through degradation of the F-box protein, Skp2, and stabilization of…”
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Different Responses of Astrocytes and Neurons to Nitric Oxide: The Role of Glycolytically Generated ATP in Astrocyte Protection by Almeida, Angeles, Almeida, Julia, Bolaños, Juan P., Moncada, Salvador

“…It was recently proposed that in Jurkat cells, after inhibition of respiration by NO, glycolytically generated ATP plays a critical role in preventing the…”
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Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress by Diaz-Hernandez, J I, Moncada, S, Bolaños, J P, Almeida, A

“…In neurons, DNA is prone to free radical damage, although repair mechanisms preserve the genomic integrity. However, activation of the DNA repair system,…”
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Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases by Bolaños, Juan P., Almeida, Angeles, Stewart, Victoria, Peuchen, Stephan, Land, John M., Clark, John B., Heales, Simon J. R.

“…: Within the CNS and under normal conditions, nitric oxide (•NO) appears to be an important physiological signalling molecule. Its ability to increase cyclic…”
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Integrating Molecular Mechanisms with Synaptic Plasticity in Neurological Disease by Nisticò, R., Bolaños, J. P., De Sarro, G. B.

“…Issue Title: Special Issue: Integrating Molecular Mechanisms with Synaptic Plasticity in Neurological Disease…”
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Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide by Bolaños, J P, Herrero-Mendez, A, Fernandez-Fernandez, S, Almeida, A

“…NO (nitric oxide) participates in a considerable number of physiological functions. At the biochemical level, most of its actions can be ascribed to its…”
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A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons by Almeida, Angeles, Bolaños, Juan P.

“…In order to investigate the relationship between nitric oxide‐mediated regulation of mitochondrial function and excitotoxicity, the role of mitochondrial ATP…”
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Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes by Bolaños, J P, Peuchen, S, Heales, S J, Land, J M, Clark, J B

“…The Ca(2+)-independent form of nitric oxide synthase was induced in rat neonatal astrocytes in primary culture by incubation with lipopolysaccharide (1…”
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Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione by Bolaños, Juan P., Heales, Simon J.R., Peuchen, Stefan, Barker, Jane E., Land, John M., Clark, John B.

“…In this study we have investigated the mechanisms leading to mitochondrial damage in cultured neurons following sustained exposure to nitric oxide. Thus, the…”
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D‐Glucose Prevents Glutathione Oxidation and Mitochondrial Damage After Glutamate Receptor Stimulation in Rat Cortical Primary Neurons by Delgado‐Esteban, María, Almeida, Angeles, Bolaños, Juan P.

“…: The possible neuroprotective effect of D‐glucose against glutamate‐mediated neurotoxicity was studied in rat cortical neurons in primary culture. Brief…”
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Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system by Peuchen, Stefan, Bolaños, Juan P., Heales, Simon J.R., Almeida, Angeles, Duchen, Michael R., Clark, John B.

“…Astrocytes have, until recently, been thought of as the passive supporting elements of the central nervous system. However, recent developments suggest that…”
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Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? by Gegg, M. E., Beltran, B., Salas‐Pino, S., Bolanos, J. P., Clark, J. B., Moncada, S., Heales, S. J. R.

“…Primary culture rat astrocytes exposed to the long acting nitric oxide donor (Z)‐1‐[2‐aminoethyl)‐N‐(2‐ammonioethyl)amino]diazen‐1‐ium‐1,2‐diolate (DETA‐NO)…”
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Effect of valproate on the metabolism of the central nervous system by Bolaños, Juan P., Medina, JoséM.

“…The effects of valproate on brain energy and lipid metabolism is reviewed. Increasing evidence suggests that valproate uses the monocarboxylic acid carrier in…”
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Expression of glucose transporter GLUT3 by endotoxin in cultured rat astrocytes: the role of nitric oxide by Cidad, Pilar, Garcia‐Nogales, Paula, Almeida, Angeles, Bolaños, Juan P.

“…The induction of nitric oxide (NO) synthase in astrocytes by endotoxin and/or cytokine treatment is associated with increased glucose consumption and…”
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Depletion of glutathione up‐regulates mitochondrial complex I expression in glial cells by VASQUEZ, Osman L, ALMEIDA, Angeles, BOLANOS, Juan P

“…Glutathione deficiency is commonly associated with mitochondrial complex I dysfunction and loss of viability in neurones, but not in glia. In order to address…”
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Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration by Barker, J E, Bolaños, J P, Land, J M, Clark, J B, Heales, S J

“…In this study we have examined the susceptibility of the mitochondrial respiratory chain of astrocytes and astrocytes depleted of glutathione to peroxynitrite…”
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Roles of nitric oxide in brain hypoxia-ischemia by Bolaños, Juan P, Almeida, Angeles

“…A large body of evidence has appeared over the last 6 years suggesting that nitric oxide biosynthesis is a key factor in the pathophysiological response of the…”
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