Search Results - "Bol, G."

A new methodology for inter- and intrafraction plan adaptation for the MR-linac by Kontaxis, Charis, Bol, G H, Lagendijk, J J W, Raaymakers, B W

“…The new era of hybrid MRI and linear accelerator machines, including the MR-linac currently being installed in the University Medical Center Utrecht (Utrecht,…”
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First patients treated with a 1.5 T MRI-Linac: clinical proof of concept of a high-precision, high-field MRI guided radiotherapy treatment by Raaymakers, B W, Jürgenliemk-Schulz, I M, Bol, G H, Glitzner, M, Kotte, A N T J, van Asselen, B, de Boer, J C J, Bluemink, J J, Hackett, S L, Moerland, M A, Woodings, S J, Wolthaus, J W H, van Zijp, H M, Philippens, M E P, Tijssen, R, Kok, J G M, de Groot-van Breugel, E N, Kiekebosch, I, Meijers, L T C, Nomden, C N, Sikkes, G G, Doornaert, P A H, Eppinga, W S C, Kasperts, N, Kerkmeijer, L G W, Tersteeg, J H A, Brown, K J, Pais, B, Woodhead, P, Lagendijk, J J W

“…The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration…”
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Towards fast online intrafraction replanning for free-breathing stereotactic body radiation therapy with the MR-linac by Kontaxis, C, Bol, G H, Stemkens, B, Glitzner, M, Prins, F M, Kerkmeijer, L G W, Lagendijk, J J W, Raaymakers, B W

“…The hybrid MRI-radiotherapy machines, like the MR-linac (Elekta AB, Stockholm, Sweden) installed at the UMC Utrecht (Utrecht, The Netherlands), will be able to…”
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Proof-of-concept delivery of intensity modulated arc therapy on the Elekta Unity 1.5 T MR-linac by Kontaxis, C, Woodhead, P L, Bol, G H, Lagendijk, J J W, Raaymakers, B W

“…In this work we present the first delivery of intensity modulated arc therapy on the Elekta Unity 1.5 T MR-linac. The machine's current intensity modulated…”
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Agreement between skeletal muscle mass measurements using computed tomography imaging and magnetic resonance imaging in head and neck cancer patients by Chargi, N., Ansari, E., Huiskamp, L.F.J., Bol, G., de Bree, R.

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Towards adaptive IMRT sequencing for the MR-linac by Kontaxis, Charis, Bol, G H, Lagendijk, J J W, Raaymakers, B W

“…The MRI linear accelerator (MR-linac) that is currently being installed in the University Medical Center Utrecht (Utrecht, The Netherlands), will be able to…”
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Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra by Bril, S. I., Wendrich, A. W., Swartz, J. E., Wegner, I., Pameijer, F., Smid, E. J., Bol, G. H., Pothen, A. J., de Bree, R.

“…Objectives Skeletal muscle mass (SMM) is most often assessed in cancer patients on abdominal computed tomography (CT) imaging at the level of the third lumbar…”
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Distinct tau and alpha-synuclein molecular signatures in Alzheimer’s disease with and without Lewy bodies and Parkinson’s disease with dementia by van der Gaag, Bram L., Deshayes, Natasja A. C., Breve, John J. P., Bol, John G. J. M., Jonker, Allert J., Hoozemans, Jeroen J. M., Courade, Jean-Philippe, van de Berg, Wilma D. J.

“…Alpha-synuclein (aSyn) pathology is present in approximately 50% of Alzheimer’s disease (AD) cases at autopsy and might impact the age-of-onset and disease…”
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Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment by Heerma van Voss, M R, Vesuna, F, Bol, G M, Afzal, J, Tantravedi, S, Bergman, Y, Kammers, K, Lehar, M, Malek, R, Ballew, M, ter Hoeve, N, Abou, D, Thorek, D, Berlinicke, C, Yazdankhah, M, Sinha, D, Le, A, Abrahams, R, Tran, P T, van Diest, P J, Raman, V

“…DDX3 is a DEAD box RNA helicase with oncogenic properties. RK-33 is developed as a small-molecule inhibitor of DDX3 and showed potent radiosensitizing activity…”
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Compensating for the impact of non-stationary spherical air cavities on IMRT dose delivery in transverse magnetic fields by Bol, G H, Lagendijk, J J W, Raaymakers, B W

“…With the development of the 1.5 T MRI linear accelerator and the clinical introduction of the 0.35 T ViewRay™ system, delivering intensity-modulated…”
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Validation of skeletal muscle mass assessment at the level of the third cervical vertebra in patients with head and neck cancer by Bril, S.I., Chargi, N., Wendrich, A.W., Wegner, I., Bol, G.H., Smid, E.J., de Jong, P.A., Devriese, L.A., de Bree, R.

“…•Correlation between cross-sectional muscle area at level C3 and L3 was good.•Agreement between estimated and actual cross-sectional muscle area at L3 was…”
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Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases by Moors, Tim E., Morella, Martino L., Bertran-Cobo, Cesc, Geut, Hanneke, Udayar, Vinod, Timmermans-Huisman, Evelien, Ingrassia, Angela M. T., Brevé, John J. P., Bol, John G. J. M., Bonifati, Vincenzo, Jagasia, Ravi, van de Berg, Wilma D. J.

“…Transcription factor EB (TFEB) is a master regulator of genes involved in the maintenance of autophagic and lysosomal homeostasis, processes which have been…”
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Development and clinical introduction of automated radiotherapy treatment planning for prostate cancer by Winkel, D, Bol, G H, van Asselen, B, Hes, J, Scholten, V, Kerkmeijer, L G W, Raaymakers, B W

“…To develop an automated radiotherapy treatment planning and optimization workflow to efficiently create patient specifically optimized clinical grade treatment…”
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Virtual couch shift (VCS): accounting for patient translation and rotation by online IMRT re-optimization by Bol, G H, Lagendijk, J J W, Raaymakers, B W

“…When delivering conventional intensity modulated radiotherapy (IMRT), discrepancies between the pre-treatment CT/MRI/PET based patient geometry and the daily…”
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Fast online Monte Carlo-based IMRT planning for the MRI linear accelerator by Bol, G H, Hissoiny, S, Lagendijk, J J W, Raaymakers, B W

“…The MRI accelerator, a combination of a 6 MV linear accelerator with a 1.5 T MRI, facilitates continuous patient anatomy updates regarding translations,…”
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Dosimetric feasibility of intensity modulated proton therapy in a transverse magnetic field of 1.5 T by Hartman, J, Kontaxis, Charis, Bol, G H, Frank, S J, Lagendijk, J J W, van Vulpen, M, Raaymakers, B W

“…Proton therapy promises higher dose conformality in comparison with regular radiotherapy techniques. Also, image guidance has an increasing role in…”
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Myelin Quantification in White Matter Pathology of Progressive Multiple Sclerosis Post-Mortem Brain Samples: A New Approach for Quantifying Remyelination by Huitema, Marije J D, Strijbis, Eva M M, Luchicchi, Antonio, Bol, John G J M, Plemel, Jason R, Geurts, Jeroen J G, Schenk, Geert J

“…Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS). Repair through remyelination can be extensive,…”
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Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis by Chrobok, Navina L, Bol, John G J M, Jongenelen, Cornelis A, Brevé, John J P, El Alaoui, Said, Wilhelmus, Micha M M, Drukarch, Benjamin, van Dam, Anne-Marie

“…The neurodegenerative disease multiple sclerosis (MS) is pathologically characterized by the massive influx of immune cells into the central nervous system…”
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Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson's disease dementia by Frigerio, Irene, Laansma, Max A, Lin, Chen-Pei, Hermans, Emma J M, Bouwman, Maud M A, Bol, John G J M, Galis-de Graaf, Yvon, Hepp, Dagmar H, Rozemuller, Annemieke J M, Barkhof, Frederik, van de Berg, Wilma D J, Jonkman, Laura E

“…Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed…”
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Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis by Prins, Marloes, Eriksson, Charlotta, Wierinckx, Anne, Bol, John G J M, Binnekade, Rob, Tilders, Fred J H, Van Dam, Anne-Marie

“…Multiple sclerosis (MS) has been mainly attributed to white matter (WM) pathology. However, recent evidence indicated the presence of grey matter (GM) lesions…”
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