Search Results - "Bokov, Alex"

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease by Caccamo, Antonella, Maldonado, Monica A., Bokov, Alex F., Majumder, Smita, Oddo, Salvatore, McGaugh, James L.

“…Cognitive dysfunction and memory loss are common features of Alzheimer's disease (AD). Abnormalities in the expression profile of immediate early genes that…”
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Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? by Bokov, Alex F, Garg, Neha, Ikeno, Yuji, Thakur, Sachin, Musi, Nicolas, DeFronzo, Ralph A, Zhang, Ning, Erickson, Rebecca C, Gelfond, Jon, Hubbard, Gene B, Adamo, Martin L, Richardson, Arlan

“…Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the…”
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DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans by Munkácsy, Erin, Khan, Maruf H, Lane, Rebecca K, Borror, Megan B, Park, Jae H, Bokov, Alex F, Fisher, Alfred L, Link, Christopher D, Rea, Shane L

“…Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be…”
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The role of oxidative damage and stress in aging by Bokov, Alex, Chaudhuri, Asish, Richardson, Arlan

“…The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is currently one of the most popular explanations for how aging occurs at…”
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Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome by Fok, Wilson C, Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B, Diaz, Vivian, Javors, Martin, Wood, 3rd, William H, Zhang, Yongqing, Becker, Kevin G, Pérez, Viviana I, Richardson, Arlan

“…Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality…”
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Profiling the anaerobic response of C. elegans using GC-MS by Butler, Jeffrey A, Mishur, Robert J, Bokov, Alex F, Hakala, Kevin W, Weintraub, Susan T, Rea, Shane L

“…The nematode Caenorhabditis elegans is a model organism that has seen extensive use over the last four decades in multiple areas of investigation. In this…”
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PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model by Liang, Huiyun, Ward, Walter F., Jang, Youngmok C., Bhattacharya, Arunabh, Bokov, Alex F., Li, Yan, Jernigan, Amanda, Richardson, Arlan, Van Remmen, Holly

“…Introduction: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. We sought to determine whether peroxisome proliferator–activated…”
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Long-Lived Ames Dwarf Mice Are Resistant to Chemical Stressors by Bokov, Alex F., Lindsey, Merry L., Khodr, Christina, Sabia, Marian R., Richardson, Arlan

“…To probe the connection between longevity and stress resistance, we compared the sensitivity of Ames long-lived dwarf mice and control littermates with…”
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74123 A Learning Health Systems approach using health record data to construct patient frailty scores and predict safety events by Bokov, Alex, Espinoza, Sara, Tripathy, Chandana, Stevens, Kathleen

“…ABSTRACT IMPACT: Laying the groundwork for better predictive algorithms to inform clinical decisions and planning. OBJECTIVES/GOALS: Frailty scores predict…”
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Probing the relationship between insulin sensitivity and longevity using genetically modified mice by Nelson, James F, Strong, Randy, Bokov, Alex, Diaz, Vivian, Ward, Walter

“…Interference in insulin and/or insulin-like growth factor 1 (IGF-1) signaling can extend invertebrate life span, and interference in IGF-1 signaling can extend…”
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Estimate risk difference and number needed to treat in survival analysis by Zhang, Zhongheng, Ambrogi, Federico, Bokov, Alex F, Gu, Hongqiu, de Beurs, Edwin, Eskaf, Khaled

“…The hazard ratio (HR) is a measure of instantaneous relative risk of an increase in one unit of the covariate of interest, which is widely reported in clinical…”
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Hepatic response to oxidative injury in long-lived Ames dwarf mice by Sun, Liou Y, Bokov, Alex F, Richardson, Arlan, Miller, Richard A

“…Multiple stress resistance pathways were evaluated in the liver of Ames dwarf mice before and after exposure to the oxidative toxin diquat, seeking clues to…”
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Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice by Lin, Ai-Ling, Pulliam, Daniel A, Deepa, Sathyaseelan S, Halloran, Jonathan J, Hussong, Stacy A, Burbank, Raquel R, Bresnen, Andrew, Liu, Yuhong, Podlutskaya, Natalia, Soundararajan, Anuradha, Muir, Eric, Duong, Timothy Q, Bokov, Alex F, Viscomi, Carlo, Zeviani, Massimo, Richardson, Arlan G, Van Remmen, Holly, Fox, Peter T, Galvan, Veronica

“…Recent studies have challenged the prevailing view that reduced mitochondrial function and increased oxidative stress are correlated with reduced longevity…”
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Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy by Bai, Xiang, Wey, Margaret Chia-Ying, Fernandez, Elizabeth, Hart, Matthew J., Gelfond, Jonathan, Bokov, Alex F., Rani, Sheela, Strong, Randy

“…Synucleinopathy is any of a group of age-related neurodegenerative disorders including Parkinson's disease, multiple system atrophy, and dementia with Lewy…”
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The Effect Of Gonadectomy And Estradiol On Sensitivity To Oxidative Stress by Bokov, Alex F., Ko, Daijin, Richardson, Arlan

“…The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The…”
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Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes by Pan, Haihui, Qin, Kunhua, Guo, Zhanyong, Ma, Yonggang, April, Craig, Gao, Xiaoli, Andrews, Thomas G., Bokov, Alex, Zhang, Jianhua, Chen, Yidong, Weintraub, Susan T., Fan, Jian-Bing, Wang, Degeng, Hu, Yanfen, Aune, Gregory J., Lindsey, Merry L., Li, Rong

“…Negative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across…”
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Patient Engagement and Attitudes Toward Using the Electronic Medical Record for Medical Research: The 2015 Greater Plains Collaborative Health and Medical Research Family Survey by Davis, Ann M, Hanrahan, Lawrence P, Bokov, Alex F, Schlachter, Sarah, Laroche, Helena H, Waitman, Lemuel Russell

“…Electronic health records (EHRs) are ubiquitous. Yet little is known about the use of EHRs for prospective research purposes, and even less is known about…”
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Early Postnatal Administration of Growth Hormone Increases Tuberoinfundibular Dopaminergic Neuron Numbers in Ames Dwarf Mice by Khodr, Christina E, Clark, Sara, Bokov, Alex F, Richardson, Arlan, Strong, Randy, Hurley, David L, Phelps, Carol J

“…Hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons secrete dopamine, which inhibits pituitary prolactin (PRL) secretion. PRL has demonstrated…”
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Rapamycin selectively alters serum chemistry in diabetic mice by Tabatabai-Mir, Hooman, Sataranatarajan, Kavithalakshmi, Lee, HakJoo, Bokov, AlexF, Fernandez, Elizabeth, Diaz, Vivian, Choudhury, GoutamGhosh, Richardson, Arlan, Kasinath, Balakuntalam S.

“…The study was undertaken to explore the effect of rapamycin, an anti-inflammatory agent, on the metabolic profile of type 2 diabetic mice. Seven-month-old…”
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A Learning Health Systems Approach to Frailty Prediction Using EHR Data by Bokov, Alex, Stevens, Kathleen, Tripathy, Chandana, Espinoza, Sara

“…Research Objective To predict occurrence of preventable patient safety events using only data elements that are almost universally supported in EHR systems…”
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