Search Results - "Bokkers, B."

Inhalation toxicity profiles of particulate matter: a comparison between brake wear with other sources of emission by Gerlofs-Nijland, M. E., Bokkers, B. G. H., Sachse, H., Reijnders, J. J. E., Gustafsson, M., Boere, A. J. F., Fokkens, P. F. H., Leseman, D. L. A. C., Augsburg, K., Cassee, F. R.

“…Objective: There is substantial evidence that exposure to airborne particulate matter (PM) from road traffic is associated with adverse health outcomes…”
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Skin sensitisation quantitative risk assessment (QRA) based on aggregate dermal exposure to methylisothiazolinone in personal care and household cleaning products by Ezendam, J., Bokkers, B.G.H., Bil, W., Delmaar, J.E.

“…Contact allergy to preservatives is an important public health problem. Ideally, new substances should be evaluated for the risk on skin sensitisation before…”
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Health impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products by Jongeneel, W.P., Delmaar, J.E., Bokkers, B.G.H.

“…A methodology to assess the health impact of skin sensitizers is introduced, which consists of the comparison of the probabilistic aggregated exposure with a…”
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Evaluating the evidence for non-monotonic dose-response relationships: A systematic literature review and (re-)analysis of in vivo toxicity data in the area of food safety by Varret, C., Beronius, A., Bodin, L., Bokkers, B.G.H., Boon, P.E., Burger, M., De Wit-Bos, L., Fischer, A., Hanberg, A., Litens-Karlsson, S., Slob, W., Wolterink, G., Zilliacus, J., Beausoleil, C., Rousselle, C.

“…This study aims to evaluate the evidence for the existence of non-monotonic dose-responses (NMDRs) of substances in the area of food safety. This review was…”
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Probabilistic derivation of the interspecies assessment factor for skin sensitization by Bil, W., Schuur, A.G., Ezendam, J., Bokkers, B.G.H.

“…An interspecies sensitization assessment factor (SAF) is used in the quantitative risk assessment (QRA) for skin sensitization when a murine-based NESIL (No…”
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Quantitative risk assessment of the aggregate dermal exposure to the sensitizing fragrance geraniol in personal care products and household cleaning agents by Nijkamp, M.M., Bokkers, B.G.H., Bakker, M.I., Ezendam, J., Delmaar, J.E.

“…A quantitative risk assessment was performed to establish if consumers are at risk for being dermally sensitized by the fragrance geraniol. Aggregate dermal…”
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First Exploration of Health Impact Assessment of Chemical Exposure: Assigning Weights to Subclinical Effects Based on Animal Studies by ter Burg, W, Bokkers, B. G. H, Kroese, E. D, Schuur, A. G

“…Health impact assessments (HIA) have become an important tool for applying evidence-based policy. Recently, the concept of HIA has been introduced in the field…”
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Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: Toxicokinetics is essential for in vivo–in vitro comparisons by van Kesteren, P. C. E., Zwart, P. E., Schaap, M. M., Pronk, T. E., van Herwijnen, M. H. M., Kleinjans, J. C. S., Bokkers, B. G. H., Godschalk, R. W. L., Zeilmaker, M. J., van Steeg, H., Luijten, M.

“…The traditional 2-year cancer bioassay needs replacement by more cost-effective and predictive tests. The use of toxicogenomics in an in vitro system may…”
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First tier modeling of consumer dermal exposure to substances in consumer articles under REACH: A quantitative evaluation of the ECETOC TRA for consumers tool by Delmaar, J.E., Bokkers, B.G.H., ter Burg, W., van Engelen, J.G.M.

“…► Comparison of ECETOC TRA dermal model with physics-based exposure model. ► ECETOC TRA did not provide conservative estimates in the scenarios considered. ►…”
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The EFSA WEB app based on PROAST: data table generation by Bokkers, B.

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S16-03 Recent advances in the risk assessment methodology for PFAS mixtures: Derivation of relative potency factors (RPFs) for PFAS by Bil, W., Zeilmaker, M., Verbruggen, E., Bokkers, B.

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S10-02 New Approach Methodologies (NAMs): a quantitative in vitro to in vivo extrapolation case study with perfluorinated compounds by Fragki, S., Paini, A., Iulini, M., Corsini, E., Bokkers, B., Luijten, M., Pijnenburg, A., Piersma, A.H., Zeilmaker, M.J., Rijkers, D., Siccardi, M., Schaller, S.

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Estimating the Kinetics of Titanium Dioxide Nanoparticles in Rats after inhalation using Physiologically Based Kinetic Modelling by Minnema, J., Delmaar, C., Gosens, I., Cassee, F.R., Tran, L., Bokkers, B

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S13-03 Case studies showing the applicability of the mixture risk assessment strategy using HBM data by Machera, K., Carsique, M., Bil, W., Palmont, P., McVey, E., Jerez, A. Hernandez, Vrijenhoek, N., Bokkers, B., McKeon, H., Mengelers, M., Ratier, A., Engel, J., van Klavaren, J., Crepet, A.

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Aggregate and cumulative exposure of bisphenols from food and personal care products: A hands-on training by Karrer, C., Delmaar, C., Bokkers, B., Hungerbühler, K., von Goetz, N.

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N3RvousSystem: A 3R systems biology strategy for human neurotoxicity hazard, risk and safety assessment by Westerink, R.H.S., Albrecht, C., Sofranko, A., Stahlmecke, B., Breitenstein, D., Pijnenburg, D., Bokkers, B., Schins, R.P.F., Heusinkveld, H.J.

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Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles by Vranic, Sandra, Gosens, Ilse, Jacobsen, Nicklas Raun, Jensen, Keld A., Bokkers, Bas, Kermanizadeh, Ali, Stone, Vicki, Baeza-Squiban, Armelle, Cassee, Flemming R., Tran, Lang, Boland, Sonja

“…Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however…”
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Minimising bins in transmission systems by Archibald, Thomas W., Bokkers, Menno B., Dekker, Rommert, Vliet, André van

“…This paper deals with the problem of minimising the transmission cost in an EDI system and proves the optimality of a policy which minimizes the slack of…”
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An appeal for the presentation of detailed human derived data for dose–response calculations in nutritional science by de Jong, Nynke, Verkaik-Kloosterman, Janneke, Verhagen, Hans, Boshuizen, Hendriek C., Bokkers, Bas, Hoekstra, Jeljer

“…If a diet, food or food constituent is recognised to have both health benefits and health risks, the benefits have to be compared with the risks to develop…”
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Minimising bins in transmission systems: Integrated Production/Distribution Planning in Supply Chains by ARCHIBALD, T. W, BOKKERS, M. B, DEKKER, R, VAN VLIET, A

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