Search Results - "Bok, Seoyeon"
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A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
Published in Nature communications (08-05-2020)“…The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and…”
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2
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
Published in Nature communications (29-07-2021)“…Hedgehog signaling is essential for bone formation, including functioning as a means for the growth plate to drive skeletal mineralization. However, the…”
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3
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I
Published in Nature communications (11-11-2020)“…Neurofibromatosis type I (NF1) is characterized by prominent skeletal manifestations caused by NF1 loss. While inhibitors of the ERK activating kinases MEK1/2…”
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4
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion
Published in Nature communications (06-08-2024)“…The skeleton has been suggested to function as an endocrine organ controlling whole organism energy balance, however the mediators of this effect and their…”
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5
Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8
Published in Proceedings of the National Academy of Sciences - PNAS (18-02-2014)“…Emerging evidence indicates that myeloid cells are essential for promoting new blood vessel formation by secreting various angiogenic factors. Given that…”
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Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization
Published in International journal of radiation oncology, biology, physics (01-07-2016)“…Purpose To investigate the serial changes of tumor hypoxia in response to single high-dose irradiation by various clinical and preclinical methods to propose…”
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Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1
Published in Laboratory animal research (30-10-2024)“…Uncoupling protein 1 (UCP1) is a proton uncoupler located across the mitochondrial membrane generally involved in thermogenesis of brown adipose tissues…”
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Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta
Published in Bone Research (26-08-2024)“…Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due to a range of genetic variants that prominently include mutations…”
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9
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging
Published in Scientific reports (10-06-2016)“…Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological…”
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10
Radiation-Induced Esophagitis In Vivo and In Vitro Reveals That Epidermal Growth Factor Is a Potential Candidate for Therapeutic Intervention Strategy
Published in International journal of radiation oncology, biology, physics (01-07-2016)“…Purpose To establish and characterize radiation-induced esophagitis (RIE) in vivo and in vitro. Methods and Materials Fractionated thoracic irradiation at 0,…”
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11
Radiation-induced immune responses: mechanisms and therapeutic perspectives
Published in Blood research (2016)Get full text
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12
Are osteoblasts multiple cell types? A new diversity in skeletal stem cells and their derivatives
Published in Journal of bone and mineral research (26-09-2024)“…Only in the past decade have skeletal stem cells (SSCs), a cell type displaying formal evidence of stemness and serving as the ultimate origin of mature…”
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13
Shaping the sinuses: a novel Krt14+Ctsk+ cell lineage driving regenerative bone formation
Published in Cell research (01-09-2022)Get full text
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14
Tumor hypoxia and reoxygenation : the yin and yang for radiotherapy
Published in Radiation oncology journal (30-12-2016)“…Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because…”
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15
Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis
Published in Cancer research (Chicago, Ill.) (15-02-2019)“…Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Here, we demonstrate that tumor-associated macrophages (TAM)…”
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16
A vertebral skeletal stem cell lineage driving metastasis
Published in Nature (London) (21-09-2023)“…Vertebral bone is subject to a distinct set of disease processes from long bones, including a much higher rate of solid tumour metastases 1 – 4 . The basis for…”
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Development of Murine Anterior Interbody and Posterolateral Spinal Fusion Techniques
Published in Journal of bone and joint surgery. American volume (17-04-2024)“…Multiple animal models have previously been utilized to investigate anterior fusion techniques, but a mouse model has yet to be developed. The purpose of this…”
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18
Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice
Published in Oncotarget (19-12-2017)“…Cells universally adapt to ischemic conditions by turning on a transcription factor hypoxia-inducible factor (HIF), in which its role is known to differ widely…”
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19
A multi-stem cell basis for craniosynostosis and calvarial mineralization
Published in Nature (London) (28-09-2023)“…Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving…”
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Quantum Dots in an Amphiphilic Polyethyleneimine Derivative Platform for Cellular Labeling, Targeting, Gene Delivery, and Ratiometric Oxygen Sensing
Published in ACS nano (23-06-2015)“…Amphiphilic polyethyleneimine derivatives (amPEIs) were synthesized and used to encapsulate dozens of quantum dots (QDs). The QD–amPEI composite was ∼100 nm in…”
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