Search Results - "Bojková, Denisa"

Construction and Characterization of a High-Capacity Replication-Competent Murine Cytomegalovirus Vector for Gene Delivery by Riedl, André, Bojková, Denisa, Tan, Jiang, Jeney, Ábris, Larsen, Pia-Katharina, Jeney, Csaba, Full, Florian, Kalinke, Ulrich, Ruzsics, Zsolt

“…We investigated the basic characteristics of a new murine cytomegalovirus (MCMV) vector platform. Using BAC technology, we engineered replication-competent…”
Get full text

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates by Bojkova, Denisa, Widera, Marek, Ciesek, Sandra, Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich

Get full text

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets by Bojkova, Denisa, Klann, Kevin, Koch, Benjamin, Widera, Marek, Krause, David, Ciesek, Sandra, Cinatl, Jindrich, Münch, Christian

“…A new coronavirus was recently discovered and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infection with SARS-CoV-2 in humans causes…”
Get full text

Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication by Klann, Kevin, Bojkova, Denisa, Tascher, Georg, Ciesek, Sandra, Münch, Christian, Cinatl, Jindrich

“…SARS-CoV-2 infections are rapidly spreading around the globe. The rapid development of therapies is of major importance. However, our lack of understanding of…”
Get full text

Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China by Hoehl, Sebastian, Rabenau, Holger, Berger, Annemarie, Kortenbusch, Marhild, Cinatl, Jindrich, Bojkova, Denisa, Behrens, Pia, Böddinghaus, Boris, Götsch, Udo, Naujoks, Frank, Neumann, Peter, Schork, Joscha, Tiarks-Jungk, Petra, Walczok, Antoni, Eickmann, Markus, Vehreschild, Maria J.G.T, Kann, Gerrit, Wolf, Timo, Gottschalk, René, Ciesek, Sandra

“…A group of 126 German nationals was evacuated from Wuhan to Frankfurt after screening for symptoms of Covid-19 and was to undergo a 14-day quarantine and…”
Get full text

Lack of antiviral activity of darunavir against SARS-CoV-2 by De Meyer, Sandra, Bojkova, Denisa, Cinatl, Jindrich, Van Damme, Ellen, Buyck, Christophe, Van Loock, Marnix, Woodfall, Brian, Ciesek, Sandra

“…•Darunavir showed no in vitro antiviral activity against SARS-CoV-2 (EC50 > 100 μM).•Remdesivir demonstrated potent antiviral activity, confirming validity of…”
Get full text

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes by Bojkova, Denisa, Wagner, Julian U G, Shumliakivska, Mariana, Aslan, Galip S, Saleem, Umber, Hansen, Arne, Luxán, Guillermo, Günther, Stefan, Pham, Minh Duc, Krishnan, Jaya, Harter, Patrick N, Ermel, Utz H, Frangakis, Achilleas S, Milting, Hendrik, Zeiher, Andreas M, Klingel, Karin, Cinatl, Jindrich, Dendorfer, Andreas, Eschenhagen, Thomas, Tschöpe, Carsten, Ciesek, Sandra, Dimmeler, Stefanie

“…Abstract Aims Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has emerged as a global pandemic…”
Get full text

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection by Ellinger, Bernhard, Bojkova, Denisa, Zaliani, Andrea, Cinatl, Jindrich, Claussen, Carsten, Westhaus, Sandra, Keminer, Oliver, Reinshagen, Jeanette, Kuzikov, Maria, Wolf, Markus, Geisslinger, Gerd, Gribbon, Philip, Ciesek, Sandra

“…SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic, in which acute respiratory infections are associated with high socio-economic burden…”
Get full text

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants by Wagner, Julian U. G., Bojkova, Denisa, Shumliakivska, Mariana, Luxán, Guillermo, Nicin, Luka, Aslan, Galip S., Milting, Hendrik, Kandler, Joshua D., Dendorfer, Andreas, Heumueller, Andreas W., Fleming, Ingrid, Bibli, Sofia-Iris, Jakobi, Tobias, Dieterich, Christoph, Zeiher, Andreas M., Ciesek, Sandra, Cinatl, Jindrich, Dimmeler, Stefanie

“…Coronavirus disease 2019 (COVID-19) spawned a global health crisis in late 2019 and is caused by the novel coronavirus SARS-CoV-2. SARS-CoV-2 infection can…”
Get full text

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies by Armstrong, Lee A, Lange, Sven M, Dee Cesare, Virginia, Matthews, Stephen P, Nirujogi, Raja Sekhar, Cole, Isobel, Hope, Anthony, Cunningham, Fraser, Toth, Rachel, Mukherjee, Rukmini, Bojkova, Denisa, Gruber, Franz, Gray, David, Wyatt, Paul G, Cinatl, Jindrich, Dikic, Ivan, Davies, Paul, Kulathu, Yogesh

“…Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large,…”
Get full text

Optimized qRT-PCR Approach for the Detection of Intra- and Extra-Cellular SARS-CoV-2 RNAs by Toptan, Tuna, Hoehl, Sebastian, Westhaus, Sandra, Bojkova, Denisa, Berger, Annemarie, Rotter, Björn, Hoffmeier, Klaus, Cinatl, Jr, Jindrich, Ciesek, Sandra, Widera, Marek

“…The novel coronavirus SARS-CoV-2 is the causative agent of the acute respiratory disease COVID-19, which has become a global concern due to its rapid spread…”
Get full text

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection by Mukherjee, Rukmini, Bhattacharya, Anshu, Bojkova, Denisa, Mehdipour, Ahmad Reza, Shin, Donghyuk, Khan, Khadija Shahed, Hei-Yin Cheung, Hayley, Wong, Kam-Bo, Ng, Wai-Lung, Cinatl, Jindrich, Geurink, Paul P., van der Heden van Noort, Gerbrand J., Rajalingam, Krishnaraj, Ciesek, Sandra, Hummer, Gerhard, Dikic, Ivan

“…Apart from prevention using vaccinations, the management options for COVID-19 remain limited. In retrospective cohort studies, use of famotidine, a specific…”
Get full text

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment by Bojkova, Denisa, Rothenburger, Tamara, Ciesek, Sandra, Wass, Mark N., Michaelis, Martin, Cinatl, Jindrich

Get full text

Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings by Widera, Marek, Westhaus, Sandra, Rabenau, Holger F., Hoehl, Sebastian, Bojkova, Denisa, Cinatl, Jindrich, Ciesek, Sandra

“…The novel coronavirus SARS-CoV-2 is the causative agent of the acute respiratory disease COVID-19, which has become a global concern due to its rapid spread…”
Get full text

SARS-CoV-2 screening strategies for returning international travellers: Evaluation of a rapid antigen test approach by Layer, Emily, Hoehl, Sebastian, Widera, Marek, Bojkova, Denisa, Westphal, Tim, Gottschalk, Rene, Boeddinghaus, Boris, Schork, Joscha, Ciesek, Sandra, Goetsch, Udo

“…•International travel enables the spread of SARS-CoV-2 and its viral variants•The antigen test showed a sensitivity of 100% with respect to in vitro…”
Get full text

Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells by Schäfer, Richard, Spohn, Gabriele, Bechtel, Marco, Bojkova, Denisa, Baer, Patrick C., Kuçi, Selim, Seifried, Erhard, Ciesek, Sandra, Cinatl, Jindrich

“…Previous studies reported on the safety and applicability of mesenchymal stem/stromal cells (MSCs) to ameliorate pulmonary inflammation in acute respiratory…”
Get full text

Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection by de Bruin, Natasja, Schneider, Ann-Kathrin, Reus, Philipp, Talmon, Sonja, Ciesek, Sandra, Bojkova, Denisa, Cinatl, Jindrich, Lodhi, Imran, Charlesworth, Bruce, Sinclair, Simon, Pennick, Graham, Laughey, William F, Gribbon, Philip, Kannt, Aimo, Schiffmann, Susanne

“…SARS-CoV-2 uses the human cell surface protein angiotensin converting enzyme 2 (ACE2) as the receptor by which it gains access into lung and other tissue…”
Get full text

Aprotinin Inhibits SARS-CoV-2 Replication by Bojkova, Denisa, Bechtel, Marco, McLaughlin, Katie-May, McGreig, Jake E, Klann, Kevin, Bellinghausen, Carla, Rohde, Gernot, Jonigk, Danny, Braubach, Peter, Ciesek, Sandra, Münch, Christian, Wass, Mark N, Michaelis, Martin, Cinatl, Jr, Jindrich

“…Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under…”
Get full text

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING by Karlowitz, Rebekka, Stanifer, Megan L., Roedig, Jens, Andrieux, Geoffroy, Bojkova, Denisa, Bechtel, Marco, Smith, Sonja, Kowald, Lisa, Schubert, Ralf, Boerries, Melanie, Cinatl, Jindrich, Boulant, Steeve, van Wijk, Sjoerd J. L.

“…Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19…”
Get full text

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy by Bojkova, Denisa, Costa, Rui, Reus, Philipp, Bechtel, Marco, Jaboreck, Mark-Christian, Olmer, Ruth, Martin, Ulrich, Ciesek, Sandra, Michaelis, Martin, Cinatl, Jindrich

“…SARS-CoV-2 is causing the coronavirus disease 2019 (COVID-19) pandemic, for which effective pharmacological therapies are needed. SARS-CoV-2 induces a shift of…”
Get full text