Synthesis of 3-aryl-2-thiohydantoin- and 3-arylhydantoin-5-acetic acids and screening of some of their pharmacological properties

Seven 3-aryl-2-thiohydantoin-5-acetic acids were obtained from asparagine and arylisothiocyanates. After desulphuration of these compounds by monochloroacetic acid seven 3-arylhydantoin-5-acetic acids were obtained. The structure of these compounds was confirmed by their IR spectra. None of the comp...

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Bibliographic Details
Published in:	Polish journal of pharmacology and pharmacy Vol. 28; no. 5; p. 423
Main Authors:	Korohoda, M J, Bojarska, A B, Kleinrok, Z, Przegaliński, E
Format:	Journal Article
Language:	English
Published:	Poland 1976
Subjects:	Animals Anticonvulsants Cyclooxygenase Inhibitors Female Hydantoins - chemical synthesis Hydantoins - pharmacology Hydantoins - toxicity Lethal Dose 50 Male Mice Thiohydantoins - chemical synthesis Thiohydantoins - pharmacology Thiohydantoins - toxicity
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Summary:	Seven 3-aryl-2-thiohydantoin-5-acetic acids were obtained from asparagine and arylisothiocyanates. After desulphuration of these compounds by monochloroacetic acid seven 3-arylhydantoin-5-acetic acids were obtained. The structure of these compounds was confirmed by their IR spectra. None of the compounds neither showed the anticonvulsive activity in the electroconvulsions and pentylenetetrazole tests nor inhibited the prostaglandin synthetase.
ISSN:	0301-0244