Search Results - "Boja, J"

The dopamine hypothesis of the reinforcing properties of cocaine by Kuhar, M J, Ritz, M C, Boja, J W

“…A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine. This hypothesis proposes that cocaine binds at the dopamine…”
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High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain by Boja, J W, Mitchell, W M, Patel, A, Kopajtic, T A, Carroll, F I, Lewin, A H, Abraham, P, Kuhar, M J

“…RTI-55 (3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester), one of the most potent inhibitors of dopamine uptake reported to date, was…”
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Cocaine and 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter by CARROLL, F. I, KOTIAN, P, ALI DEHGHANI, GRAY, J. L, KUZEMKO, M. A, PARHAM, K. A, ABRAHAM, P, LEWIN, A. H, BOJA, J. W, KUHAR, M. J

“…Several 2 beta-carboxylic acid ester and amide analogues of cocaine and of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid were prepared. The…”
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Rate of binding of various inhibitors at the dopamine transporter in vivo by STATHIS, M, SCHEFFEL, U, LEVER, S. Z, BOJA, J. W, CARROLL, F. I, KUHAR, M. J

“…The rate of entry of drugs into brain is thought to be a factor in their abuse liability. In this investigation, we have examined the rate of entry and binding…”
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Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters by CARROLL, F. I, YIGONG GAO, ABDUR RAHMAN, M, ABRAHAM, P, PARHAM, K, LEWIN, A. H, BOJA, J. W, KUHAR, M. J

“…A series of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters (2) were synthesized and found to possess high affinity for the cocaine…”
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3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogs of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters by Carroll, F. Ivy, Gray, Jeffrey L, Abraham, Philip, Kuzemko, Michael A, Lewin, Anita H, Boja, John W, Kuhar, Michael J

“…Previous studies have shown that 3 beta-(substituted phenyl)tropan-2 beta-carboxylic acid esters possess high affinity for the cocaine binding site on the…”
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Secondary amine analogues of 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters by BOJA, J. W, KUHAR, M. J, KOPAJTIC, T, YANG, E, ABRAHAM, P, LEWIN, A. H, CARROLL, F. I

“…N-Norcocaine (2) and six N-nor-3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters (4a-f) were synthesized by N-demethylation of cocaine (1)…”
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Selective labeling of the dopamine transporter by the high affinity ligand 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester by Boja, J W, Cadet, J L, Kopajtic, T A, Lever, J, Seltzman, H H, Wyrick, C D, Lewin, A H, Abraham, P, Carroll, F I

“…The iodine-125 analog of the dopaminergically selective cocaine analog 3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester (RT1-121) was…”
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Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency by Cline, E J, Scheffel, U, Boja, J W, Carroll, F I, Katz, J L, Kuhar, M J

“…Several novel cocaine analogs, previously shown to be very potent in in vitro binding studies, have been examined for their stimulatory effects on locomotor…”
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Synthesis and Transporter Binding Properties of 3β-(4‘-Alkyl-, 4‘-alkenyl-, and 4‘-alkynylphenyl)nortropane-2β-carboxylic Acid Methyl Esters:  Serotonin Transporter Selective Analogs by Blough, Bruce E, Abraham, Philip, Lewin, Anita H, Kuhar, Michael J, Boja, John W, Carroll, F. Ivy

“…New methods for the synthesis of 3β-(4‘-alkyl-, 4‘-alkenyl-, and 4‘-alkynylphenyl)nortropane-2β-carboxylic acid methyl esters 2−4, respectively, were…”
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[125I]RTI-55: a potent ligand for dopamine transporters by Boja, J W, Patel, A, Carroll, F I, Rahman, M A, Philip, A, Lewin, A H, Kopajtic, T A, Kuhar, M J

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Inhibition of striatal dopamine transporter activity by 17 β-estradiol by Disshon, Kimberly A, Boja, John W, Dluzen, Dean E

“…Striatal synaptosomes from ovariectomized rats were prepared to examine the effect of 17 β-estradiol on [ 3H]dopamine uptake. Estradiol inhibited [ 3H]dopamine…”
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Isopropyl and phenyl esters of 3β-(4-substituted phenyl)tropan-2β-carboxylic acids. Potent and selective compounds for the dopamine transporter by IVY CARROLL, F, ABRAHAM, P, LEWIN, A. H, PARHAM, K. A, BOJA, J. W, KUHAR, M. J

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Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121 by Staley, J K, Boja, J W, Carroll, F I, Seltzman, H H, Wyrick, C D, Lewin, A H, Abraham, P, Mash, D C

“…The novel cocaine analog RTI-121 [3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester] was evaluated as a probe for the in vitro labeling and…”
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Highly potent cocaine analogs cause long-lasting increases in locomotor activity by Fleckenstein, Annette E., Kopajtic, Theresa A., Boja, John W., Carroll, F.Ivy, Kuhar, Michael J.

“…Three cocaine analogs were compared with cocaine for the capacity to affect: (1) dopamine transporter binding and function; and (2) locomotor activity. RTI-55…”
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Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogs at the dopamine transporter by Carroll, F. Ivy, Lewin, Anita H, Boja, John W, Kuhar, Michael J

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In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428 by Scheffel, U, Pögün, S, Stathis, M, Boja, J W, Kuhar, M J

“…After in vivo administration, [3H]WIN 35,428 accumulated in mouse brain regions containing dopaminergic nerve terminals. The highest accumulation was in the…”
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[3H]cocaine binding and inhibition of [3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens by Boja, J W, Kuhar, M J

“…Cocaine binds with high affinity to the dopamine transporter in both the striatum and the nucleus accumbens. We examined Na(+)-dependent [3H]cocaine binding,…”
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Halogenated Mazindol Analogs as Potential Inhibitors of the Cocaine Binding Site at the Dopamine Transporter by Houlihan, William J, Boja, John W, Parrino, Vincent A, Kopajtic, Theresa A, Kuhar, Michael J

“…A series of halogenated (F, Cl, Br, I), pyrimido and diazepino homologs of mazindol were prepared and evaluated for their ability to displace [3H]WIN 35,428…”
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3α-(4‘-Substituted phenyl)tropane- 2β-carboxylic Acid Methyl Esters:  Novel Ligands with High Affinity and Selectivity at the Dopamine Transporter by Holmquist, Christopher R, Keverline-Frantz, Kathryn I, Abraham, Philip, Boja, John W, Kuhar, Michael J, Carroll, F. Ivy

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