Search Results - "Boivin, Isabel"

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia by Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy

“…To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated 200 sequenced primary specimens. Mubritinib, a known ERBB2…”
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Genetic characterization of ABT-199 sensitivity in human AML by Bisaillon, Richard, Moison, Céline, Thiollier, Clarisse, Krosl, Jana, Bordeleau, Marie-Eve, Lehnertz, Bernhard, Lavallée, Vincent-Philippe, MacRae, Tara, Mayotte, Nadine, Labelle, Caroline, Boucher, Geneviève, Spinella, Jean-François, Boivin, Isabel, D’Angelo, Giovanni, Lavallée, Sylvie, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy

“…Acute myeloid leukemias (AML) with mutations in the NPM1 gene (NPM1c+) represent a large AML subgroup with varying response to conventional treatment,…”
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Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors by Lavallée, Vincent-Philippe, Krosl, Jana, Lemieux, Sébastien, Boucher, Geneviève, Gendron, Patrick, Pabst, Caroline, Boivin, Isabel, Marinier, Anne, Guidos, Cynthia J., Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy

“…In this study, we analyzed RNA-sequencing data of 14 samples characterized by biallelic CEBPA (CEBPAbi) mutations included in the Leucegene collection of 415…”
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RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature by Lavallée, Vincent-Philippe, Lemieux, Sébastien, Boucher, Geneviève, Gendron, Patrick, Boivin, Isabel, Armstrong, Richard N., Sauvageau, Guy, Hébert, Josée

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Immunotherapeutic targeting of surfaceome heterogeneity in AML by Bordeleau, Marie-Eve, Audemard, Éric, Métois, Arnaud, Theret, Louis, Lisi, Véronique, Farah, Azer, Spinella, Jean-François, Chagraoui, Jalila, Moujaber, Ossama, Aubert, Léo, Khakipoor, Banafsheh, Mallinger, Laure, Boivin, Isabel, Mayotte, Nadine, Hajmirza, Azadeh, Bonneil, Éric, Béliveau, François, Pfammatter, Sybille, Feghaly, Albert, Boucher, Geneviève, Gendron, Patrick, Thibault, Pierre, Barabé, Frédéric, Lemieux, Sébastien, Richard-Carpentier, Guillaume, Hébert, Josée, Lavallée, Vincent-Philippe, Roux, Philippe P., Sauvageau, Guy

“…Immunotherapy remains underexploited in acute myeloid leukemia (AML) compared to other hematological malignancies. Currently, gemtuzumab ozogamicin is the only…”
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HLF expression defines the human hematopoietic stem cell state by Lehnertz, Bernhard, Chagraoui, Jalila, MacRae, Tara, Tomellini, Elisa, Corneau, Sophie, Mayotte, Nadine, Boivin, Isabel, Durand, Aurélie, Gracias, Deanne, Sauvageau, Guy

“…Hematopoietic stem cells (HSCs) sustain blood cell homeostasis throughout life and can regenerate all blood lineages after transplantation. Despite this clear…”
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H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations by Lehnertz, Bernhard, Zhang, Yu Wei, Boivin, Isabel, Mayotte, Nadine, Tomellini, Elisa, Chagraoui, Jalila, Lavallée, Vincent-Philippe, Hébert, Josée, Sauvageau, Guy

“…Neomorphic missense mutations affecting crucial lysine residues in histone H3 genes significantly contribute to a variety of solid cancers. Despite the high…”
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GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo by Pabst, Caroline, Bergeron, Anne, Lavallée, Vincent-Philippe, Yeh, Jonathan, Gendron, Patrick, Norddahl, Gudmundur L., Krosl, Jana, Boivin, Isabel, Deneault, Eric, Simard, Jessica, Imren, Suzan, Boucher, Geneviève, Eppert, Kolja, Herold, Tobias, Bohlander, Stefan K., Humphries, Keith, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy, Barabé, Frédéric

“…Acute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy, which is initiated and driven by a rare fraction of leukemia stem cells…”
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High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML by Simon, Laura, Spinella, Jean-François, Yao, Chi-Yuan, Lavallée, Vincent-Philippe, Boivin, Isabel, Boucher, Geneviève, Audemard, Eric, Bordeleau, Marie-Eve, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy

“…RUNX1 is mutated in ∼10% of adult acute myeloid leukemia (AML). Although most RUNX1 mutations in this disease are believed to be acquired, they can also be…”
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Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML by Moison, Céline, Gracias, Deanne, Schmitt, Julie, Girard, Simon, Fortier, Simon, Boivin, Isabel, Spinella, Jean-Francois, Macrae, Tara, Ruel, Rejean, Hebert, Josee, Marinier, Anne, Sauvageau, Guy

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3019 – CRISPR-BASED ENGINEERING OF A REPORTER ALLELE DEMONSTRATES THAT HLF EXPRESSION DEFINES THE HUMAN HAEMATOPOIETIC STEM CELL STATE by Lehnertz, Bernhard, MacRae, Tara, Chagraoui, Jalila, Tomellini, Elisa, Corneau, Sophie, Mayotte, Nadine, Boivin, Isabel, Sauvageau, Guy

“…Haematopoietic stem cells (HSCs) sustain blood cell homeostasis throughout life and are able to regenerate all blood lineages following transplantation…”
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DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML by Spinella, Jean-François, Chagraoui, Jalila, Moison, Céline, Lavallée, Vincent P., Boivin, Isabel, Gracias, Deanne, Lavallée, Sylvie, Carpentier, Guillaume Richard, Beliveau, François, Hébert, Josée, Sauvageau, Guy

“…Monosomy 5 and deletions of the chromosome 5q (−5/del(5q)) are recurrent events in de novo adult acute myeloid leukemia (AML), reaching up to 40% of cases in…”
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Identification of Acute Myeloid Leukemia Cell Surface Therapeutic Targets Using Single Cell RNA Sequencing Supported By Surface Proteomics by Lisi, Véronique, Khakipoor, Banafsheh, Farah, Azer, Bordeleau, Marie-Eve, Audemard, Eric, Metois, Arnaud, Theret, Louis, Spinella, Jean-François, Chagraoui, Jalila, Moujaber, Ossama, Mallinger, Laure, Boivin, Isabel, Mayotte, Nadine, Hajmirza, Azadeh, Bonneil, Eric, Béliveau, Francois, Feghali, Albert, Boucher, Geneviève, Gendron, Patrick, Barabe, Frederic, Lemieux, Sebastien, Richard-Carpentier, Guillaume, Hébert, Josée, Roux, Philippe, Sauvageau, Guy, Lavallee, Vincent-Philippe

“…Background: Acute myeloid leukemia (AML) comprises diverse genomic subgroups and remains hard to treat in most patients. Despite breakthroughs in the…”
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Chemogenomic Profiling of Complex Karyotype AML Reveals a Novel Susceptibility to G2/M Checkpoint Inhibition Mediated By HMGA2 Overexpression by Moison, Céline, Lavallee, Vincent-Philippe, Thiollier, Clarisse, Spinella, Jean-Francois, Boivin, Isabel, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

“…Background: Acute myeloid leukemia (AML) with complex karyotype (CK) is associated with adverse prognosis with current therapies, in particular in the presence…”
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Identification of Novel Antigens for Normal Karyotype Triple Mutated Acute Myeloid Leukemia by Metois, Arnaud, Bordeleau, Marie-Eve, Theret, Louis, Hajmirza, Azadeh, Moujaber, Ossama, Spinella, Jean-François, Chagraoui, Jalila, Mayotte, Nadine, Boivin, Isabel, Audemard, Eric, Farah, Azer, Lisi, Véronique, Bonneil, Eric, Thibault, Pierre, Richard-Carpentier, Guillaume, Lavallée, Vincent-Philippe, Hebert, Josee, Roux, Philippe P, Sauvageau, Guy

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Identification of Novel Cell Surface Therapeutic Targets for KMT2A-Rearranged Acute Myeloid Leukemia by Theret, Louis, Bordeleau, Marie-Eve, Hajmirza, Azadeh, Metois, Arnaud, Moujaber, Ossama, Audemard, Eric, Spinella, Jean-Francois, Chagraoui, Jalila, Aubert, Léo, Farah, Azer, Lisi, Véronique, Bonneil, Eric, Boivin, Isabel, Mayotte, Nadine, MacRae, Tara, Thibault, Pierre, Lemieux, Sébastien, Lavallée, Vincent-Philippe, Hebert, Josee, Sauvageau, Guy, Roux, Philippe P

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Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines by Safa-Tahar-Henni, Safia, Páez Martinez, Karla, Gress, Verena, Esparza, Nayeli, Roques, Élodie, Bonnet-Magnaval, Florence, Bilodeau, Mélanie, Gagné, Valérie, Bresson, Eva, Cardin, Sophie, El-Hachem, Nehme, Iasenza, Isabella, Alzial, Gabriel, Boivin, Isabel, Nakamichi, Naoto, Soufflet, Anne-Cécile, Mirela Pascariu, Cristina, Duchaine, Jean, Mathien, Simon, Bonneil, Éric, Eppert, Kolja, Marinier, Anne, Sauvageau, Guy, Deblois, Geneviève, Thibault, Pierre, Hébert, Josée, Eaves, Connie J, Cellot, Sonia, Barabé, Frédéric, Wilhelm, Brian T

“…Targeted therapeutics for high-risk cancers remain an unmet medical need. Here we report the results of a large-scale screen of over 11,000 molecules for their…”
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3114 – HMGA2 OVEREXPRESSION CONFERS SENSITIVITY TO G2/M INHIBITORS IN ACUTE MYELOID LEUKEMIA by Moison, Céline, Spinella, Jean-Francois, Lavallée, Vincent-Philippe, Thiollier, Clarisse, Lehnertz, Bernhard, Chagraoui, Jalila, Boivin, Isabel, Marinier, Anne, Hébert, Josée, Sauvageau, Guy

“…Complex karyotype (CK) acute myeloid leukemia (AML), especially those with TP53 anomalies, are particularly resistant to current therapies and remain one of…”
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H3K27M/I Mutations Promote Context-Dependent Transformation in Acute Myeloid Leukemia with RUNX1 Alterations by Lehnertz, Bernhard, Zhang, Yu Wei, Boivin, Isabel, Mayotte, Nadine, Elisa, Tomellini, Chagraoui, Jalila, Lavallée, Vincent-Philippe, Hébert, Josée, Sauvageau, Guy

“…Neomorphic missense mutations in histone H3 genes (most notably K27M and K36M) are frequent in solid cancers such as diffuse intrinsic pontine gliomas (DIPG),…”
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H3 K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations by Lehnertz, Bernhard, Zhang, Yu Wei, Boivin, Isabel, Mayotte, Nadine, Tomellini, Elisa, Chagraoui, Jalila, Lavallée, Vincent-Philippe, Hébert, Josée, Sauvageau, Guy

“…Neomorphic missense mutations affecting crucial lysine residues in histone H3 genes significantly contribute to a variety of solid cancers. Despite the high…”
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