Search Results - "Boise, L. H."

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion by Konen, J., Summerbell, E., Dwivedi, B., Galior, K., Hou, Y., Rusnak, L., Chen, A., Saltz, J., Zhou, W., Boise, L. H., Vertino, P., Cooper, L., Salaita, K., Kowalski, J., Marcus, A. I.

“…Phenotypic heterogeneity is widely observed in cancer cell populations. Here, to probe this heterogeneity, we developed an image-guided genomics technique…”
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Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax by Bajpai, R, Matulis, S M, Wei, C, Nooka, A K, Von Hollen, H E, Lonial, S, Boise, L H, Shanmugam, M

“…Multiple myeloma (MM) is a plasma cell malignancy that is largely incurable due to development of resistance to therapy-elicited cell death. Nutrients are…”
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Expression of Bcl-XL can confer a multidrug resistance phenotype by MINN, A. J, RUDIN, C. M, BOISE, L. H, THOMPSON, C. B

“…It has been suggested that genes that regulate apoptotic cell death may play an important role in determining the sensitivity of tumor cells to chemotherapy…”
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Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients by Nooka, A K, Kaufman, J L, Muppidi, S, Langston, A, Heffner, L T, Gleason, C, Casbourne, D, Saxe, D, Boise, L H, Lonial, S

“…Prior studies have shown that myeloma patients exhibiting either genetically defined high-risk disease or plasma cell leukemia have a poor outcome with a…”
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Dexamethasone treatment promotes Bcl-2 dependence in multiple myeloma resulting in sensitivity to venetoclax by Matulis, S M, Gupta, V A, Nooka, A K, Hollen, H V, Kaufman, J L, Lonial, S, Boise, L H

“…Venetoclax (ABT-199), a specific inhibitor of the anti-apoptotic protein Bcl-2, is currently in phase I clinical trials for multiple myeloma. The results…”
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Multiple Bcl-2 Family Members Demonstrate Selective Dimerizations with Bax by Sedlak, Thomas W., Oltvai, Zoltan N., Yang, Elizabeth, Wang, Kun, Boise, Lawrence H., Thompson, Craig B., Korsmeyer, Stanley J.

“…A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to…”
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Growth Factors can Enhance Lymphocyte Survival without Committing the Cell to Undergo Cell Division by Boise, Lawrence H., Minn, Andy J., June, Carl H., Lindsten, Tullia, Thompson, Craig B.

“…Growth factors have been defined by their ability to promote the proliferative expansion of receptor-bearing cells. For example, antigen-activated T cells…”
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Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo by Wrone-Smith, T, Johnson, T, Nelson, B, Boise, LH, Thompson, CB, Nunez, G, Nickoloff, BJ

“…Apoptosis is a required event in maintaining kinetic homeostasis within continually renewing tissues such as skin. However, no systematic study of the…”
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Bcl-2 and Bcl-2-related proteins in apoptosis regulation by Boise, L H, Gottschalk, A R, Quintáns, J, Thompson, C B

“…In this review we have discussed the importance of Bcl-2 and related proteins in the regulation of apoptotic cell death in mammalian systems. It is clear that…”
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CD30 Signals Integrate Expression of Cytotoxic Effector Molecules, Lymphocyte Trafficking Signals, and Signals for Proliferation and Apoptosis by Muta, Hiromi, Boise, Lawrence H, Fang, Lei, Podack, Eckhard R

“…Although CD30 has long been recognized as an important marker on many lymphomas of diverse origin and as activation molecule on B cells and T cells, its…”
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The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB by BOISE, L. H, PETRYNIAK, B, XIAOHONG MAO, JUNE, C. H, CHUNG-YIH WANG, LINDSTEN, T, BRAVO, R, KOVARY, K, LEIDEN, J. M, THOMPSON, C. B

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Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype by Guo, X, Koff, J L, Moffitt, A B, Cinar, M, Ramachandiran, S, Chen, Z, Switchenko, J M, Mosunjac, M, Neill, S G, Mann, K P, Bagirov, M, Du, Y, Natkunam, Y, Khoury, H J, Rossi, M R, Harris, W, Flowers, C R, Lossos, I S, Boise, L H, Dave, S S, Kowalski, J, Bernal-Mizrachi, L

“…Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like…”
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bcl-x is Expressed in Embryonic and Postnatal Neural Tissues and Functions to Prevent Neuronal Cell Death by González-García, Maribel, García, Irene, Ding, Liyun, O'Shea, Sue, Boise, Lawrence H., Thompson, Craig B., Núñez, Gabriel

“…Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking functional bcl-2 exhibited normal…”
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Identification of Immunosuppressant-Induced Apoptosis in a Murine B-Cell Line and its Prevention by bcl-x but not bcl-2 by Gottschalk, Alexander R., Boise, Lawrence H., Thompson, Craig B., Quintans, Jose

“…Cyclosporin A, FK-506, and rapamycin are immunosuppressants often used as pharmacological probes to study lymphocyte activation and physiological cell death…”
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Acquisition of a multidrug-resistant phenotype with a proteasome inhibitor in multiple myeloma by Gutman, D, Morales, A A, Boise, L H

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Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors by Wang, C Y, Bassuk, A G, Boise, L H, Thompson, C B, Bravo, R, Leiden, J M

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Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia by Gaudette, B T, Dwivedi, B, Chitta, K S, Poulain, S, Powell, D, Vertino, P, Leleu, X, Lonial, S, Chanan-Khan, A A, Kowalski, J, Boise, L H

“…Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The…”
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Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons by Prehn, J H, Bindokas, V P, Jordán, J, Galindo, M F, Ghadge, G D, Roos, R P, Boise, L H, Thompson, C B, Krajewski, S, Reed, J C, Miller, R J

“…Neurodegeneration associated with Alzheimer's disease is believed to involve toxicity to beta-amyloid (A beta) and related peptides. Treatment of cultured rat…”
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Azidothymidine and interferon-α induce apoptosis in herpesvirus-associated lymphomas by LEE, R. K, CAI, J.-P, HARRINGTON, W. J, DEYEV, V, GILL, P. S, CABRAL, L, WOOD, C, AGARWAL, R. P, WENIE XIA, BOISE, L. H, PODACK, E

“…Lymphoproliferative diseases that occur in immunocompromised patients are frequently associated with herpesviruses. These patients often fare poorly after…”
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Bcl-XL and Bcl-2 repress a common pathway of cell death by Chao, D T, Linette, G P, Boise, L H, White, L S, Thompson, C B, Korsmeyer, S J

“…The effect of Bcl-xL upon the developmental death of T cells was assessed by generating transgenic mice that expressed Bcl-xL within all thymocyte subsets…”
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