Search Results - "Boise, L"

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion by Konen, J., Summerbell, E., Dwivedi, B., Galior, K., Hou, Y., Rusnak, L., Chen, A., Saltz, J., Zhou, W., Boise, L. H., Vertino, P., Cooper, L., Salaita, K., Kowalski, J., Marcus, A. I.

“…Phenotypic heterogeneity is widely observed in cancer cell populations. Here, to probe this heterogeneity, we developed an image-guided genomics technique…”
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Targeting glutamine metabolism in multiple myeloma enhances BIM binding to BCL-2 eliciting synthetic lethality to venetoclax by Bajpai, R, Matulis, S M, Wei, C, Nooka, A K, Von Hollen, H E, Lonial, S, Boise, L H, Shanmugam, M

“…Multiple myeloma (MM) is a plasma cell malignancy that is largely incurable due to development of resistance to therapy-elicited cell death. Nutrients are…”
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Consolidation and maintenance therapy with lenalidomide, bortezomib and dexamethasone (RVD) in high-risk myeloma patients by Nooka, A K, Kaufman, J L, Muppidi, S, Langston, A, Heffner, L T, Gleason, C, Casbourne, D, Saxe, D, Boise, L H, Lonial, S

“…Prior studies have shown that myeloma patients exhibiting either genetically defined high-risk disease or plasma cell leukemia have a poor outcome with a…”
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Dexamethasone treatment promotes Bcl-2 dependence in multiple myeloma resulting in sensitivity to venetoclax by Matulis, S M, Gupta, V A, Nooka, A K, Hollen, H V, Kaufman, J L, Lonial, S, Boise, L H

“…Venetoclax (ABT-199), a specific inhibitor of the anti-apoptotic protein Bcl-2, is currently in phase I clinical trials for multiple myeloma. The results…”
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Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype by Guo, X, Koff, J L, Moffitt, A B, Cinar, M, Ramachandiran, S, Chen, Z, Switchenko, J M, Mosunjac, M, Neill, S G, Mann, K P, Bagirov, M, Du, Y, Natkunam, Y, Khoury, H J, Rossi, M R, Harris, W, Flowers, C R, Lossos, I S, Boise, L H, Dave, S S, Kowalski, J, Bernal-Mizrachi, L

“…Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like…”
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Acquisition of a multidrug-resistant phenotype with a proteasome inhibitor in multiple myeloma by Gutman, D, Morales, A A, Boise, L H

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Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia by Gaudette, B T, Dwivedi, B, Chitta, K S, Poulain, S, Powell, D, Vertino, P, Leleu, X, Lonial, S, Chanan-Khan, A A, Kowalski, J, Boise, L H

“…Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The…”
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Dementia Assessment in Primary Care: Results From a Study in Three Managed Care Systems by Boise, Linda, Neal, Margaret B., Kaye, Jeffrey

“…Background. Prior research has found that dementia is often undiagnosed in primary care, but there has been limited research on whether physicians respond to…”
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Attitudes Toward the Diagnosis and Disclosure of Dementia Among Family Caregivers and Primary Care Physicians by Connell, Cathleen M, Boise, Linda, Stuckey, John C., Holmes, Sara B., Hudson, Margaret L.

“…Purpose: This study examined attitudes of caregivers and physicians toward assessing and diagnosing dementia, with an emphasis on how a diagnosis is disclosed…”
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Expression of Bcl-XL can confer a multidrug resistance phenotype by MINN, A. J, RUDIN, C. M, BOISE, L. H, THOMPSON, C. B

“…It has been suggested that genes that regulate apoptotic cell death may play an important role in determining the sensitivity of tumor cells to chemotherapy…”
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Multiple Bcl-2 Family Members Demonstrate Selective Dimerizations with Bax by Sedlak, Thomas W., Oltvai, Zoltan N., Yang, Elizabeth, Wang, Kun, Boise, Lawrence H., Thompson, Craig B., Korsmeyer, Stanley J.

“…A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to…”
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Diagnosing Dementia: Perspectives of Primary Care Physicians by Boise, Linda, Camicioli, Richard, Morgan, David L., Rose, Julia H., Congleton, Leslie

“…As few as 50% of dementia cases are diagnosed by physicians. This study investigated how primary care physicians assess patients for dementia and identified…”
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CD30 Signals Integrate Expression of Cytotoxic Effector Molecules, Lymphocyte Trafficking Signals, and Signals for Proliferation and Apoptosis by Muta, Hiromi, Boise, Lawrence H, Fang, Lei, Podack, Eckhard R

“…Although CD30 has long been recognized as an important marker on many lymphomas of diverse origin and as activation molecule on B cells and T cells, its…”
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Growth Factors can Enhance Lymphocyte Survival without Committing the Cell to Undergo Cell Division by Boise, Lawrence H., Minn, Andy J., June, Carl H., Lindsten, Tullia, Thompson, Craig B.

“…Growth factors have been defined by their ability to promote the proliferative expansion of receptor-bearing cells. For example, antigen-activated T cells…”
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Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo by Wrone-Smith, T, Johnson, T, Nelson, B, Boise, LH, Thompson, CB, Nunez, G, Nickoloff, BJ

“…Apoptosis is a required event in maintaining kinetic homeostasis within continually renewing tissues such as skin. However, no systematic study of the…”
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bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria by GONZALEZ-GARCIA, M, PEREZ-BALLESTERO, R, LIYUNG DING, DUAN, L, BOISE, L. H, THOMPSON, C. B, NUNEZ, G

“…Most examples of cell death in animals are controlled by a genetic program that is activated within the dying cell. The apoptotic process is further regulated…”
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bcl-x is Expressed in Embryonic and Postnatal Neural Tissues and Functions to Prevent Neuronal Cell Death by González-García, Maribel, García, Irene, Ding, Liyun, O'Shea, Sue, Boise, Lawrence H., Thompson, Craig B., Núñez, Gabriel

“…Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking functional bcl-2 exhibited normal…”
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Identification of Immunosuppressant-Induced Apoptosis in a Murine B-Cell Line and its Prevention by bcl-x but not bcl-2 by Gottschalk, Alexander R., Boise, Lawrence H., Thompson, Craig B., Quintans, Jose

“…Cyclosporin A, FK-506, and rapamycin are immunosuppressants often used as pharmacological probes to study lymphocyte activation and physiological cell death…”
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Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation by Boise, L H, Thompson, C B

“…Programmed cell death or apoptosis provides an irreversible mechanism for the elimination of excess or damaged cells. Several recent studies have implicated…”
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Bcl-2 and Bcl-2-related proteins in apoptosis regulation by Boise, L H, Gottschalk, A R, Quintáns, J, Thompson, C B

“…In this review we have discussed the importance of Bcl-2 and related proteins in the regulation of apoptotic cell death in mammalian systems. It is clear that…”
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