Multicenter Retrospective Study of Vascular Infections and Endocarditis Caused by Campylobacter spp., France

The incidence of campylobacteriosis has substantially increased over the past decade, notably in France. Secondary localizations complicating invasive infections are poorly described. We aimed to describe vascular infection or endocarditis caused by Campylobacter spp. We included 57 patients from a...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 29; no. 3; pp. 484 - 492
Main Authors:	Tinévez, Claire, Lehours, Philippe, Ranc, Anne-Gaëlle, Belaroussi, Yaniss, Cazanave, Charles, Puges, Mathilde, Velardo, Fanny, Dubois, Damien, Neuwirth, Catherine, Pailhoriès, Hélène, Dorel, Marie, Hery-Arnaud, Genevieve, Join-Lambert, Olivier, Gras, Emmanuelle, Corvec, Stéphane, Codde, Cyrielle, Fournier, Damien, Boijout, Hugo, Doat, Violaine, Bouard, Leslie, Lagneaux, Anne-Sophie, Pichon, Maxime, Couzigou, Célia, Letellier, Claire, Lemaignen, Adrien, Bille, Emmanuelle, Bérard, Xavier, Caradu, Caroline, Webster, Claire, Neau, Didier
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-03-2023 Centers for Disease Control and Prevention
Subjects:	Abscesses Anti-Bacterial Agents Anti-Bacterial Agents - therapeutic use Antibiotics Aortic aneurysms Bacteremia Bacteremia - diagnosis bacteria bacterial infections Beta lactamases Biopsy Blood circulation disorders Campylobacter Campylobacter fetus Campylobacter Infections Campylobacter Infections - drug therapy Campylobacter spp Causes of Complications and side effects Coronary vessels Endocarditis Endocarditis - drug therapy Endocarditis, Bacterial France graft infections Health aspects Human health and pathology Humans Imipenem Infection Infections infectious aortitis Infectious diseases Leukocytes Life Sciences Medical research Medicine, Experimental Mortality Multicenter Retrospective Study of Vascular Infections and Endocarditis Caused by Multicenter Studies as Topic non-HACEK endocarditis Pacemakers Prostheses Retrospective Studies Risk factors spp., France Statistics Tetracycline Tetracyclines Ticarcillin Tomography France Campylobacter spp infectious aortitis bacteria non-HACEK endocarditis France bacterial infections graft infections thrombophlebitis
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Summary:	The incidence of campylobacteriosis has substantially increased over the past decade, notably in France. Secondary localizations complicating invasive infections are poorly described. We aimed to describe vascular infection or endocarditis caused by Campylobacter spp. We included 57 patients from a nationwide 5-year retrospective study on Campylobacter spp. bacteremia conducted in France; 44 patients had vascular infections, 12 had endocarditis, and 1 had both conditions. Campylobacter fetus was the most frequently involved species (83%). Antibiotic treatment involved a β-lactam monotherapy (54%) or was combined with a fluoroquinolone or an aminoglycoside (44%). The mortality rate was 25%. Relapse occurred in 8% of cases and was associated with delayed initiation of an efficient antimicrobial therapy after the first symptoms, diabetes, and coexistence of an osteoarticular location. Cardiovascular Campylobacter spp. infections are associated with a high mortality rate. Systematically searching for those localizations in cases of C. fetus bacteremia may be warranted.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2903.221417