Search Results - "Bohrmann, Bernd"

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle by Niewoehner, Jens, Bohrmann, Bernd, Collin, Ludovic, Urich, Eduard, Sade, Hadassah, Maier, Peter, Rueger, Petra, Stracke, Jan Olaf, Lau, Wilma, Tissot, Alain C, Loetscher, Hansruedi, Ghosh, Anirvan, Freskgård, Per-Ola

“…Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB)…”
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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance by Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian

“…Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid…”
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3D Structure of Alzheimer's Amyloid-β(1-42) Fibrils by Lührs, Thorsten, Christiane Ritter, Adrian, Marc, Dominique Riek-Loher, Bohrmann, Bernd, Döbeli, Heinz, Schubert, David, Riek, Roland, Gage, Fred H.

“…Alzheimer's disease is the most fatal neurodegenerative disorder wherein the process of amyloid-β (Aβ) amyloidogenesis appears causative. Here, we present the…”
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Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2 by Claes, Christel, Van Den Daele, Johanna, Boon, Ruben, Schouteden, Sarah, Colombo, Alessio, Monasor, Laura Sebastian, Fiers, Mark, Ordovás, Laura, Nami, FatemehArefeh, Bohrmann, Bernd, Tahirovic, Sabina, De Strooper, Bart, Verfaillie, Catherine M.

“…Murine microglia expressing the Alzheimer's disease–linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is…”
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Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode by Weber, Felix, Bohrmann, Bernd, Niewoehner, Jens, Fischer, Jens A.A., Rueger, Petra, Tiefenthaler, Georg, Moelleken, Joerg, Bujotzek, Alexander, Brady, Kevin, Singer, Thomas, Ebeling, Martin, Iglesias, Antonio, Freskgård, Per-Ola

“…Receptors show promise for the transport of monoclonal antibodies (mAbs) across the blood-brain barrier. However, safety liabilities associated with peripheral…”
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Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice by Grueninger, Fiona, Bohrmann, Bernd, Czech, Christian, Ballard, Theresa Maria, Frey, Johann R, Weidensteiner, Claudia, von Kienlin, Markus, Ozmen, Laurence

“…Abstract Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine…”
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Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor by Rauch, Ursula, Bonderman, Diana, Bohrmann, Bernd, Badimon, Juan J., Himber, Jacques, Riederer, Markus A., Nemerson, Yale

“…We describe thrombogenic tissue factor (TF) on leukocyte-derived microparticles and their incorporation into spontaneous human thrombi. Polymorphonuclear…”
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Blood-Borne Tissue Factor: Another View of Thrombosis by Peter L. A. Giesen, Rauch, Ursula, Bohrmann, Bernd, Kling, Dorothee, Roque, Merce, Fallon, John T., Badimon, Juan J., Himber, Jacques, Riederer, Markus A., Nemerson, Yale

“…Arterial thrombosis is considered to arise from the interaction of tissue factor (TF) in the vascular wall with platelets and coagulation factors in…”
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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model by Melo, Esther, Oertle, Philipp, Trepp, Carolyn, Meistermann, Hélène, Burgoyne, Thomas, Sborgi, Lorenzo, Cabrera, Alvaro Cortes, Chen, Chia-yi, Hoflack, Jean-Christophe, Kam-Thong, Tony, Schmucki, Roland, Badi, Laura, Flint, Nicholas, Ghiani, Zeynep Eren, Delobel, Fréderic, Stucki, Corinne, Gromo, Giulia, Einhaus, Alfred, Hornsperger, Benoit, Golling, Sabrina, Siebourg-Polster, Juliane, Gerber, Francoise, Bohrmann, Bernd, Futter, Clare, Dunkley, Tom, Hiller, Sebastian, Schilling, Oliver, Enzmann, Volker, Fauser, Sascha, Plodinec, Marija, Iacone, Roberto

“…Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss. The protein HtrA1 is enriched in retinal pigment epithelial (RPE)…”
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Acute Renal Effects of Intravenous Bisphosphonates in the Rat by Pfister, Thomas, Atzpodien, Elke, Bohrmann, Bernd, Bauss, Frieder

“…: Bisphosphonates are potent osteoclast inhibitors that have been associated with renal toxicity following rapid intravenous administration of high doses,…”
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Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis by IHLING, Christian, SZOMBATHY, Thomas, BOHRMANN, Bernd, BROCKHAUS, Manfred, SCHAEFER, Hans E, LOEFFLER, Bernd M

“…Endothelin-converting enzyme (ECE)-1 activates endothelin-1 (ET-1) and may thus contribute to the regulation of vascular tone and cell growth during…”
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Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: Comprehensive phenotyping of vascular and tissular parameters by MRI by Weidensteiner, Claudia, Metzger, Friedrich, Bohrmann, Andreas Bruns Bernd, Kuennecke, Basil, von Kienlin, Markus

“…Function and morphology of the cerebral vasculature were studied in the amyloid (Aβ) plaque‐containing double‐transgenic (TG) B6.PS2APP Alzheimer's disease…”
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Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease by COLLIN, Ludovic, BOHRMANN, Bernd, GÖPFERT, Ulrich, OROSZLAN-SZOVIK, Krisztina, OZMEN, Laurence, GRÜNINGER, Fiona

“…The severity of tau pathology in Alzheimer's disease brain correlates closely with disease progression. Tau immunotherapy has therefore been proposed as a new…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice by Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd

“…Therapeutic approaches for prevention or reduction of amyloidosis are currently a main objective in basic and clinical research on Alzheimer's disease. Among…”
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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β by Bohrmann, Bernd, Baumann, Karlheinz, Benz, Jörg, Gerber, Francoise, Huber, Walter, Knoflach, Frédéric, Messer, Jürg, Oroszlan, Krisztina, Rauchenberger, Robert, Richter, Wolfgang F, Rothe, Christine, Urban, Margit, Bardroff, Michael, Winter, Michael, Nordstedt, Christer, Loetscher, Hansruedi

“…The amyloid-β lowering capacity of anti-Aβ antibodies has been demonstrated in transgenic models of Alzheimer's disease (AD) and in AD patients. While the…”
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A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies by Lathuilière, Aurélien, Laversenne, Vanessa, Astolfo, Alberto, Kopetzki, Erhard, Jacobsen, Helmut, Stampanoni, Marco, Bohrmann, Bernd, Schneider, Bernard L, Aebischer, Patrick

“…Passive immunization against misfolded toxic proteins is a promising approach to treat neurodegenerative disorders. For effective immunotherapy against…”
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Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice by Barrow, Paul, Villabruna, Loris, Hoberman, Alan, Bohrmann, Bernd, Richter, Wolfgang F, Schubert, Christine

“…•Gantenerumab is intended for treatment of Alzheimer’s disease (AD).•It is an IgG1 which binds aggregated forms of amyloid beta in the brain.•Conventional…”
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Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation by Brendel, Matthias, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Probst, Federico, Gildehaus, Franz-Josef, Bartenstein, Peter, Haass, Christian, Bohrmann, Bernd, Herms, Jochen, Willem, Michael, Rominger, Axel

“…Beta secretase (BACE) inhibitors are promising therapeutic compounds currently in clinical phase II/III trials. Preclinical [ F]-florbetaben (FBB) amyloid PET…”
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Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles by Navarro, Paula P., Genoud, Christel, Castaño-Díez, Daniel, Graff-Meyer, Alexandra, Lewis, Amanda J., de Gier, Yvonne, Lauer, Matthias E., Britschgi, Markus, Bohrmann, Bernd, Frank, Stephan, Hench, Jürgen, Schweighauser, Gabriel, Rozemuller, Annemieke J. M., van de Berg, Wilma D. J., Stahlberg, Henning, Shahmoradian, Sarah H.

“…Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward,…”
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