Search Results - "Bohren, M"

Respectful care during childbirth in health facilities globally: a qualitative evidence synthesis by Shakibazadeh, E, Namadian, M, Bohren, MA, Vogel, JP, Rashidian, A, Nogueira Pileggi, V, Madeira, S, Leathersich, S, Tunçalp, Ӧ, Oladapo, OT, Souza, JP, Gülmezoglu, AM

“…Background What constitutes respectful maternity care (RMC) operationally in research and programme implementation is often variable. Objectives To develop a…”
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Obstetric transition: the pathway towards ending preventable maternal deaths by Souza, JP, Tunçalp, Ö, Vogel, JP, Bohren, M, Widmer, M, Oladapo, OT, Say, L, Gülmezoglu, AM, Temmerman, M

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NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility by Kiyozumi, Daiji, Noda, Taichi, Yamaguchi, Ryo, Tobita, Tomohiro, Matsumura, Takafumi, Shimada, Kentaro, Kodani, Mayo, Kohda, Takashi, Fujihara, Yoshitaka, Ozawa, Manabu, Yu, Zhifeng, Miklossy, Gabriella, Bohren, Kurt M, Horie, Masato, Okabe, Masaru, Matzuk, Martin M, Ikawa, Masahito

“…The lumicrine system is a postulated signaling system in which testis-derived (upstream) secreted factors enter the male reproductive tract to regulate…”
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Promoting respect and preventing mistreatment during childbirth by Vogel, JP, Bohren, MA, Tunçalp, Ӧ, Oladapo, OT, Gülmezoglu, AM

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Factors affecting use of magnesium sulphate for pre‐eclampsia or eclampsia: a qualitative evidence synthesis by Eddy, KE, Vogel, JP, Zahroh, RI, Bohren, MA

“…Background Hypertensive disorders account for 14% of global maternal deaths. Magnesium sulphate (MgSO4) is recommended for prevention and treatment of…”
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C–N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis by Chen, Ying-Chu, Faver, John C, Ku, Angela F, Miklossy, Gabriella, Riehle, Kevin, Bohren, Kurt M, Ucisik, Melek N, Matzuk, Martin M, Yu, Zhifeng, Simmons, Nicholas

“…DNA-encoded chemical library (DECL) screens are a rapid and economical tool to identify chemical starting points for drug discovery. As a robust transformation…”
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Outcomes to measure the effects of pharmacological interventions for pain management for women during labour and birth: a review of systematic reviews and randomised trials by Tan, A, Wilson, AN, Eghrari, D, Clark, H, Tse, WC, Bohren, MA, Homer, CSE, Vogel, JP

“…Background Pharmacological pain management options can relieve women’s pain during labour and birth. Trials of these interventions have used a wide variety of…”
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Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis by Li, Jian-Yuan, Miklossy, Gabriella, Modukuri, Ram K, Bohren, Kurt M, Yu, Zhifeng, Palaniappan, Murugesan, Faver, John C, Riehle, Kevin, Matzuk, Martin M, Simmons, Nicholas

“…A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)­aryl halides on DNA–chemical conjugates has been developed. This method…”
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A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus by Bohren, Kurt M., Nadkarni, Varsha, Song, Jian H., Gabbay, Kenneth H., Owerbach, David

“…Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance…”
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Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR-/- Mice by Depner, Christopher M, Traber, Maret G, Bobe, Gerd, Kensicki, Elizabeth, Bohren, Kurt M, Milne, Ginger, Jump, Donald B, Müller, Michael

“…Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk factor for cirrhosis, hepatocellular carcinoma and…”
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A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation by Owerbach, David, McKay, Eileen M., Yeh, Edward T.H., Gabbay, Kenneth H., Bohren, Kurt M.

“…Four small ubiquitin-related modifier (SUMO) genes have been identified in humans. However, little is known about the basic biology of SUMO-4. Here, we report…”
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DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors by Jimmidi, Ravikumar, Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Chen, Peng-Jen, Bohren, Kurt M., Moghadasi, Seyed Arad, Versteeg, Leroy, Nnabuife, Christina, Li, Jian-Yuan, Qin, Xuan, Chen, Ying-Chu, Faver, John C., Nyshadham, Pranavanand, Sharma, Kiran L., Sankaran, Banumathi, Judge, Allison, Yu, Zhifeng, Li, Feng, Pollet, Jeroen, Harris, Reuben S., Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.

“…The development of SARS-CoV-2 main protease (M pro ) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting…”
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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library by Dawadi, Surendra, Simmons, Nicholas, Miklossy, Gabriella, Bohren, Kurt M., Faver, John C., Ucisik, Melek Nihan, Nyshadham, Pranavanand, Yu, Zhifeng, Matzuk, Martin M.

“…DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging…”
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Identification and Characterization of Multiple Osmotic Response Sequences in the Human Aldose Reductase Gene by Ko, Ben C.B., Ruepp, Barbara, Bohren, Kurt M., Gabbay, Kenneth H., Chung, Stephen S.M.

“…Aldose reductase (AR) has been implicated in osmoregulation in the kidney because it reduces glucose to sorbitol, which can serve as an osmolite. Under…”
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Implementation and evaluation of nonclinical interventions for appropriate use of cesarean section in low- and middle-income countries: protocol for a multisite hybrid effectiveness-implementation type III trial by Dumont, Alexandre, Betrán, Ana Pilar, Kaboré, Charles, de Loenzien, Myriam, Lumbiganon, Pisake, Bohren, Meghan A, Mac, Quoc Nhu Hung, Opiyo, Newton, Carroli, Guillermo, Annerstedt, Kristi Sidney, Ridde, Valéry, Escuriet, Ramón, Robson, Michael, Hanson, Claudia

“…While cesarean sections (CSs) are a life-saving intervention, an increasing number are performed without medical reasons in low- and middle-income countries…”
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An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications by Wilson, David K., Bohren, Kurt M., Gabbay, Kenneth H., Quiocho, Florante A.

“…Aldose reductase, which catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and…”
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Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening by Modukuri, Ram K., Monsivais, Diana, Li, Feng, Palaniappan, Murugesan, Bohren, Kurt M., Tan, Zhi, Ku, Angela F., Wang, Yong, Madasu, Chandrashekhar, Li, Jian-Yuan, Tang, Suni, Miklossy, Gabriella, Palmer, Stephen S., Young, Damian W., Matzuk, Martin M.

“…The discovery of monokinase-selective inhibitors for patients is challenging because the 500+ kinases encoded by the human genome share highly conserved…”
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors by Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Bohren, Kurt M., Chen, Ying-Chu, Du, Huang-Chi, Faver, John C., Jimmidi, Ravikumar, Li, Feng, Li, Jian-Yuan, Nyshadham, Pranavanand, Palmer, Stephen S., Pollet, Jeroen, Qin, Xuan, Ronca, Shannon E., Sankaran, Banumathi, Sharma, Kiran L., Tan, Zhi, Versteeg, Leroy, Yu, Zhifeng, Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug…”
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Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology by Madasu, Chandrashekhar, Liao, Zian, Parks, Sydney E, Sharma, Kiran L, Bohren, Kurt M, Ye, Qiuji, Li, Feng, Palaniappan, Murugesan, Tan, Zhi, Yuan, Fei, Creighton, Chad J, Tang, Suni, Masand, Ramya P, Guan, Xiaoming, Young, Damian W, Monsivais, Diana, Matzuk, Martin M

“…EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream substrates upon binding of ephrin cell surface-associated ligands. In a…”
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Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries by Monty, Olivier B. C, Nyshadham, Pranavanand, Bohren, Kurt M, Palaniappan, Murugesan, Matzuk, Martin M, Young, Damian W, Simmons, Nicholas

“…Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA–chemical conjugates lead to poor yields of the…”
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