Search Results - "Bohnen, Nicolaas"

The cholinergic system and Parkinson disease by Bohnen, Nicolaas I., Albin, Roger L.

“…Although Parkinson disease (PD) is viewed traditionally as a motor syndrome secondary to nigrostriatal dopaminergic denervation, recent studies emphasize…”
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Cholinergic system changes of falls and freezing of gait in Parkinson's disease by Bohnen, Nicolaas I., Kanel, Prabesh, Zhou, Zhi, Koeppe, Robert A., Frey, Kirk A., Dauer, William T., Albin, Roger L., Müller, Martijn L.T.M.

“…Objective Postural instability and gait difficulties (PIGDs) represent debilitating disturbances in Parkinson's disease (PD). Past acetylcholinesterase…”
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Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson's disease by Schumacher, Julia, Kanel, Prabesh, Dyrba, Martin, Storch, Alexander, Bohnen, Nicolaas I, Teipel, Stefan, Grothe, Michel J

“…Cognitive decline in Parkinson's disease is related to cholinergic system degeneration, which can be assessed in vivo using structural MRI markers of basal…”
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The middle managers: thalamic and cholinergic contributions to coordinating top-down and bottom-up processing by Lustig, Cindy, Bohnen, Nicolaas I

“…Methodological advances have facilitated extensive revision of traditional views of thalamic and cholinergic contributions to cognition and behavior…”
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Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson's disease by Crowley, Samuel J, Kanel, Prabesh, Roytman, Stiven, Bohnen, Nicolaas I, Hampstead, Benjamin M

“…Most individuals with Parkinson's disease experience cognitive decline. Mounting evidence suggests this is partially caused by cholinergic denervation due to…”
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Vulnerabilities of Aging and Biological Effects of Physical Activity Provide New Clues for Interventions in Parkinson’s Disease by Bohnen, Nicolaas I

“…Parkinson's disease (PD) is a common neurodegenerative disorder resulting in motor, cognitive, psychiatric, sleep, sensory, and autonomic disturbances. The…”
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Atrophy of the Cholinergic Basal Forebrain can Detect Presynaptic Cholinergic Loss in Parkinson's Disease by Ray, Nicola J., Kanel, Prabesh, Bohnen, Nicolaas I.

“…Objectives Structural imaging of the cholinergic basal forebrain may provide a biomarker for cholinergic system integrity that can be used in motor and…”
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Freezing of gait: understanding the complexity of an enigmatic phenomenon by Weiss, Daniel, Schoellmann, Anna, Fox, Michael D, Bohnen, Nicolaas I, Factor, Stewart A, Nieuwboer, Alice, Hallett, Mark, Lewis, Simon J G

“…Diverse but complementary methodologies are required to uncover the complex determinants and pathophysiology of freezing of gait. To develop future therapeutic…”
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Imaging: What can it tell us about parkinsonian gait? by Bohnen, Nicolaas I., Jahn, Klaus

“…ABSTRACT Functional neuroimaging has provided new tools to study cerebral gait control in Parkinson's disease (PD). First, imaging of blood flow functions has…”
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Striatal Acetylcholine-Dopamine Imbalance in Parkinson Disease: In Vivo Neuroimaging Study with Dual-Tracer PET and Dopaminergic PET-Informed Correlational Tractography by Sanchez-Catasus, Carlos A, Bohnen, Nicolaas I, D'Cruz, Nicholas, Müller, Martijn L T M

“…Previous studies of animal models of Parkinson disease (PD) suggest an imbalance between striatal acetylcholine and dopamine, although other studies have…”
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Cholinergic innervation topography in GBA-associated de novo Parkinson's disease patients by Slingerland, Sofie, van der Zee, Sygrid, Carli, Giulia, Slomp, Anne C, Boertien, Jeffrey M, d'Angremont, Emile, Bohnen, Nicolaas I, Albin, Roger L, van Laar, Teus

“…The most common genetic risk factors for Parkinson's disease are GBA1 mutations, encoding the lysosomal enzyme glucocerebrosidase. Patients with GBA1 mutations…”
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Cholinergic system correlates of postural control changes in Parkinson’s disease freezers by Roytman, Stiven, Paalanen, Rebecca, Griggs, Alexis, David, Simon, Pongmala, Chatkaew, Koeppe, Robert A, Scott, Peter J H, Marusic, Uros, Kanel, Prabesh, Bohnen, Nicolaas I

“…Abstract Postural instability and freezing of gait are the most debilitating dopamine-refractory motor impairments in advanced stages of Parkinson’s disease…”
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Sleep Disturbance as Potential Risk and Progression Factor for Parkinson's Disease by Bohnen, Nicolaas I, Hu, Michele T M

“…Sleep disturbances are common and a major source of disability in Parkinson's disease (PD). Primary and secondary insomnia, rapid eye movement sleep behavior…”
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Body-first versus brain-first biological subtyping of Parkinson's disease by Bohnen, Nicolaas I, Postuma, Ronald B

“…This scientific commentary refers to ‘Brain-first versus body-first Parkinson’s disease: a multi-modal imaging case-control study’, by Horsager etal…”
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Altered Cholinergic Innervation in De Novo Parkinson's Disease with and Without Cognitive Impairment by Zee, Sygrid, Kanel, Prabesh, Gerritsen, Marleen J.J., Boertien, Jeffrey M., Slomp, Anne C., Müller, Martijn L.T.M., Bohnen, Nicolaas I., Spikman, Jacoba M., Laar, Teus

“…Background Altered cholinergic innervation plays a putative role in cognitive impairment in Parkinson's disease (PD) at least in advanced stages…”
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Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches by Bohnen, Nicolaas I, Yarnall, Alison J, Weil, Rimona S, Moro, Elena, Moehle, Mark S, Borghammer, Per, Bedard, Marc-André, Albin, Roger L

“…In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur in different brain regions. These changes correlate with a range of…”
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Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs by Rosano, Caterina, Metti, Andrea L, Rosso, Andrea L, Studenski, Stephanie, Bohnen, Nicolaas I

“…Abstract Objective Parkinsonian motor signs are common and disabling in older adults without Parkinson’s disease (PD), but its risk factors are not completely…”
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White matter lesions in Parkinson disease by Bohnen, Nicolaas I., Albin, Roger L.

“…Age-associated white matter lesions are commonly observed in patients with idiopathic Parkinson disease, and are expected to contribute to the clinical…”
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Discussion of Research Priorities for Gait Disorders in Parkinson's Disease by Bohnen, Nicolaas I., Costa, Rui M., Dauer, William T., Factor, Stewart A., Giladi, Nir, Hallett, Mark, Lewis, Simon J.G., Nieuwboer, Alice, Nutt, John G., Takakusaki, Kaoru, Kang, Un Jung, Przedborski, Serge, Papa, Stella M.

“…ABSTRACT Gait and balance abnormalities develop commonly in Parkinson's disease and are among the motor symptoms most disabling and refractory to dopaminergic…”
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Brain PET in suspected dementia: patterns of altered FDG metabolism by Brown, Richard K J, Bohnen, Nicolaas I, Wong, Ka Kit, Minoshima, Satoshi, Frey, Kirk A

“…The diagnosis of dementia syndromes can be challenging for clinicians, particularly in the early stages of disease. Patients with higher education levels may…”
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