Search Results - "Bohn, Martha C"

The "Perivascular Pump" Driven by Arterial Pulsation is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain by Hadaczek, Piotr, Yamashita, Yoji, Mirek, Hanna, Tamas, Laszlo, Bohn, Martha C, Noble, Charles, Park, John W, Bankiewicz, Krystof

“…We investigated the movement of interstitially infused macromolecules within the central nervous system (CNS) in rats with high and low blood pressure…”
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AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS by Jara, Javier H, Villa, Stephanie R, Khan, Nabil A, Bohn, Martha C, Özdinler, P. Hande

“…Abstract Corticospinal motor neurons (CSMN) are the cortical component of motor neuron circuitry, which controls voluntary movement and degenerates in diseases…”
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Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease by Glavaski-Joksimovic, Aleksandra, Virag, Tamas, Mangatu, Thomas A., McGrogan, Michael, Wang, Xue Song, Bohn, Martha C.

“…Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons. The therapeutic…”
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Novel Magnetic Hydroxyapatite Nanoparticles as Non-Viral Vectors for the Glial Cell Line-Derived Neurotrophic Factor Gene by Wu, Hsi-Chin, Wang, Tzu-Wei, Bohn, Martha C., Lin, Feng-Huei, Spector, Myron

“…Nanoparticles (NPs) of synthetic hydroxyapatite (Hap) and natural bone mineral (NBM) are rendered magnetic by treatment with iron ions using a wet‐chemical…”
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Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies by Malchenko, Sergey, Xie, Jianping, de Fatima Bonaldo, Maria, Vanin, Elio F., Bhattacharyya, Bula J., Belmadani, Abdelhak, Xi, Guifa, Galat, Vasily, Goossens, William, Seftor, Richard E.B., Tomita, Tadanori, Crispino, John, Miller, Richard J., Bohn, Martha C., Hendrix, Mary J.C., Soares, Marcelo B.

“…In vitro neural differentiation of human embryonic stem cells (hESCs) is an advantageous system for studying early neural development. The process of early…”
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Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitors by Glavaski-Joksimovic, Aleksandra, Virag, Tamas, Chang, Qin A, West, Neva C, Mangatu, Thomas A, McGrogan, Michael P, Dugich-Djordjevic, Millicent, Bohn, Martha C

“…Parkinson's disease (PD) is a common neurodegenerative disease characterized by the selective loss of dopaminergic (DA) neurons in the midbrain. Various types…”
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Mesenchymal stem cells and neuroregeneration in Parkinson's disease by Glavaski-Joksimovic, Aleksandra, Bohn, Martha C.

“…Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a progressive and extensive loss of dopaminergic (DA) neurons in the…”
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Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy by Choi-Lundberg, Derek L., Lin, Qing, Chang, Yung-Nien, Chiang, Yawen L., Hay, Carl M., Mohajeri, Hasan, Davidson, Beverly L., Bohn, Martha C.

“…Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector…”
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Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: Positive and negative effects by Khodr, Christina E, Becerra, Amanda, Han, Ye, Bohn, Martha C

“…Abstract Background : Alpha-synuclein (SNCA) downregulation shows therapeutic potential for synucleinopathies, including Parkinson’s disease (PD). Previously…”
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Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function by Jara, Javier H, Genç, Barış, Cox, Gregory A, Bohn, Martha C, Roos, Raymond P, Macklis, Jeffrey D, Ulupınar, Emel, Özdinler, P Hande

“…Corticospinal motor neurons (CSMN) receive, integrate, and relay cerebral cortex's input toward spinal targets to initiate and modulate voluntary movement…”
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Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration by Connor, Bronwen, Kozlowski, Dorothy A., Unnerstall, James R., Elsworth, John D., Tillerson, Jennifer L., Schallert, Timothy, Bohn, Martha C.

“…Previously, we observed that injection of an adenoviral (Ad) vector expressing glial cell line-derived neurotrophic factor (GDNF) into the striatum, but not…”
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A microRNA embedded AAV alpha-synuclein gene silencing vector for dopaminergic neurons by Han, Ye, Khodr, Christina E, Sapru, Mohan K, Pedapati, Jyothi, Bohn, Martha C

“…Abstract Alpha-synuclein (SNCA), an abundantly expressed presynaptic protein, is implicated in Parkinson's disease (PD). Since over-expression of human SNCA…”
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Motoneurons crave glial cell line-derived neurotrophic factor by Bohn, Martha C.

“…This is a commentary on the developmental and therapeutic relevance of recent studies in the glial fibrillary acid protein (GFAP)-glial cell line-derived…”
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Silencing of human α-synuclein in vitro and in rat brain using lentiviral-mediated RNAi by Sapru, Mohan K., Yates, Jonathan W., Hogan, Shea, Jiang, Lixin, Halter, Jeremy, Bohn, Martha C.

“…Human α-synuclein overexpression and its toxic accumulation in neurons or glia are known to play key roles in the pathogenesis of Parkinson's disease and other…”
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Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra by Khodr, Christina E, Pedapati, Jyothi, Han, Ye, Bohn, Martha C

“…Experimental models of Parkinson's disease (PD) created by aberrant expression of the alpha-synuclein (SNCA) coding region have been reported. However,…”
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Hypothalamic IGF-I Gene Therapy Prolongs Estrous Cyclicity and Protects Ovarian Structure in Middle-Aged Female Rats by Rodríguez, Silvia S, Schwerdt, José I, Barbeito, Claudio G, Flamini, Mirta A, Han, Ye, Bohn, Martha C, Goya, Rodolfo G

“…There is substantial evidence that age-related ovarian failure in rats is preceded by abnormal responsiveness of the neuroendocrine axis to estrogen positive…”
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An alpha-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons by Khodr, Christina E, Sapru, Mohan K, Pedapati, Jyothi, Han, Ye, West, Neva C, Kells, Adrian P, Bankiewicz, Krystof S, Bohn, Martha C

“…Abstract Effects of silencing ectopically expressed hSNCA in rat substantia nigra (SN) were examined as a novel therapeutic approach to Parkinson's disease…”
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Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of parkinson's disease does not involve activation of caspase-9 and caspase-3 by Ebert, Allison D., Hann, Hoo Jae, Bohn, Martha C.

“…6‐Hydroxydopamine (6‐OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease…”
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Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects cortical neurons from dying following a traumatic brain injury by Minnich, Jennie E, Mann, Sarah L, Stock, Megan, Stolzenbach, Kathryn A, Mortell, Bridget M, Soderstrom, Katherine E, Bohn, Martha C, Kozlowski, Dorothy A

“…The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) gene delivery was examined in a rodent model of traumatic brain injury (TBI),…”
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Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold by Bolliet, Catherine, Bohn, Martha C, Spector, Myron

“…Recent advances in tissue engineering that combine an extracellular matrix-like scaffold with therapeutic molecules, cells, DNA encoding therapeutic proteins,…”
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