Search Results - "Bohn, Markus‐Frederik"

Phage display assisted discovery of a pH‐dependent anti‐α‐cobratoxin antibody from a natural variable domain library by Tulika, Tulika, Pedersen, Rasmus W., Rimbault, Charlotte, Ahmadi, Shirin, Rivera‐de‐Torre, Esperanza, Fernández‐Quintero, Monica L., Loeffler, Johannes R., Bohn, Markus‐Frederik, Ljungars, Anne, Ledsgaard, Line, Voldborg, Bjørn G., Ruso‐Julve, Fulgencio, Andersen, Jan Terje, Laustsen, Andreas H.

“…Recycling IgG antibodies bind to their target antigen at physiological pH in the blood stream and release them upon endocytosis when pH levels drop, allowing…”
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A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display by Rimbault, Charlotte, Knudsen, Pelle D., Damsbo, Anna, Boddum, Kim, Ali, Hanif, Hackney, Celeste M., Ellgaard, Lars, Bohn, Markus-Frederik, Laustsen, Andreas H.

“…Phage display technology is a powerful tool for selecting monoclonal antibodies against a diverse set of antigens. Within toxinology, however, it remains…”
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Ehlers-Danlos Syndrome Caused by Biallelic TNXB Variants in Patients with Congenital Adrenal Hyperplasia by Chen, Wuyan, Perritt, Ashley F., Morissette, Rachel, Dreiling, Jennifer L., Bohn, Markus-Frederik, Mallappa, Ashwini, Xu, Zhi, Quezado, Martha, Merke, Deborah P.

“…ABSTRACT Some variants that cause autosomal‐recessive congenital adrenal hyperplasia (CAH) also cause hypermobility type Ehlers–Danlos syndrome (EDS) due to…”
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Cross-reactivity trends when selecting scFv antibodies against snake toxins using a phage display-based cross-panning strategy by Sørensen, Christoffer V., Ledsgaard, Line, Wildenauer, Helen H. K., Dahl, Camilla H., Ebersole, Tasja W., Bohn, Markus-Frederik, Ljungars, Anne, Jenkins, Timothy P., Laustsen, Andreas H.

“…Antibodies with cross-reactive binding and broad toxin-neutralizing capabilities are advantageous for treating indications such as infectious diseases and…”
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Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A by Carpenter, Michael A., Li, Ming, Rathore, Anurag, Lackey, Lela, Law, Emily K., Land, Allison M., Leonard, Brandon, Shandilya, Shivender M.D., Bohn, Markus-Frederik, Schiffer, Celia A., Brown, William L., Harris, Reuben S.

“…Multiple studies have indicated that the TET oxidases and, more controversially, the activation-induced cytidine deaminase/APOBEC deaminases have the capacity…”
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The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization by Bohn, Markus-Frederik, Shandilya, Shivender M D, Silvas, Tania V, Nalivaika, Ellen A, Kouno, Takahide, Kelch, Brian A, Ryder, Sean P, Kurt-Yilmaz, Nese, Somasundaran, Mohan, Schiffer, Celia A

“…Deaminase activity mediated by the human APOBEC3 family of proteins contributes to genomic instability and cancer. APOBEC3A is by far the most active in this…”
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Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain by Bohn, Markus-Frederik, Shandilya, Shivender M.D., Albin, John S., Kouno, Takahide, Anderson, Brett D., McDougle, Rebecca M., Carpenter, Michael A., Rathore, Anurag, Evans, Leah, Davis, Ahkillah N., Zhang, JingYing, Lu, Yongjian, Somasundaran, Mohan, Matsuo, Hiroshi, Harris, Reuben S., Schiffer, Celia A.

“…Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal…”
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REdiii: a pipeline for automated structure solution by Bohn, Markus-Frederik, Schiffer, Celia A.

“…High‐throughput crystallographic approaches require integrated software solutions to minimize the need for manual effort. REdiii is a system that allows fully…”
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A computational analysis of the structural determinants of APOBEC3’s catalytic activity and vulnerability to HIV-1 Vif by Shandilya, Shivender M.D, Bohn, Markus-Frederik, Schiffer, Celia A

“…Abstract APOBEC3s (A3) are Zn2+ dependent cytidine deaminases with diverse biological functions and implications for cancer and immunity. Four of the seven…”
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Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope by Avnir, Yuval, Prachanronarong, Kristina L., Zhang, Zhen, Hou, Shurong, Peterson, Eric C., Sui, Jianhua, Zayed, Hatem, Kurella, Vinodh B., McGuire, Andrew T., Stamatatos, Leonidas, Hilbert, Brendan J., Bohn, Markus-Frederik, Kowalik, Timothy F., Jensen, Jeffrey D., Finberg, Robert W., Wang, Jennifer P., Goodall, Margaret, Jefferis, Roy, Zhu, Quan, Kurt Yilmaz, Nese, Schiffer, Celia A., Marasco, Wayne A.

“…The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and…”
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A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy by Zhang, Ziyang, Rohweder, Peter J, Ongpipattanakul, Chayanid, Basu, Koli, Bohn, Markus-Frederik, Dugan, Eli J, Steri, Veronica, Hann, Byron, Shokat, Kevan M, Craik, Charles S

“…Immunotargeting of tumor-specific antigens is a powerful therapeutic strategy. Immunotherapies directed at MHC-I complexes have expanded the scope of antigens…”
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Immunotargeting of Nanocrystals by SpyCatcher Conjugation of Engineered Antibodies by Pedroso, Cassio C. S, Mann, Victor R, Zuberbühler, Kathrin, Bohn, Markus-Frederik, Yu, Jessica, Altoe, Virginia, Craik, Charles S, Cohen, Bruce E

“…Inorganic nanocrystals such as quantum dots (QDs) and upconverting nanoparticles (UCNPs) are uniquely suited for quantitative live-cell imaging and are…”
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Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α‑Neurotoxins from Elapid Snakes by Wade, Jack, Rimbault, Charlotte, Ali, Hanif, Ledsgaard, Line, Rivera-de-Torre, Esperanza, Abou Hachem, Maher, Boddum, Kim, Mirza, Nadia, Bohn, Markus-Frederik, Sakya, Siri A., Ruso-Julve, Fulgencio, Andersen, Jan Terje, Laustsen, Andreas H.

“…Recombinantly produced biotherapeutics hold promise for improving the current standard of care for snakebite envenoming over conventional serotherapy…”
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The challenges with developing therapeutic monoclonal antibodies for pandemic application by Laustsen, Andreas H, Bohn, Markus-Frederik, Ljungars, Anne

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Discovery of a human monoclonal antibody that cross-neutralizes venom phospholipase A2s from three different snake genera by Sørensen, Christoffer V., Almeida, José R., Bohn, Markus-Frederik, Rivera-de-Torre, Esperanza, Schoffelen, Sanne, Voldborg, Bjørn G., Ljungars, Anne, Vaiyapuri, Sakthivel, Laustsen, Andreas H.

“…Despite the considerable global impact of snakebite envenoming, available treatments remain suboptimal. Here, we report the discovery of a broadly-neutralizing…”
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A comparative study of protein structure prediction tools for challenging targets: Snake venom toxins by Kalogeropoulos, Konstantinos, Bohn, Markus-Frederik, Jenkins, David E, Ledergerber, Jann, Sørensen, Christoffer V, Hofmann, Nils, Wade, Jack, Fryer, Thomas, Thi Tuyet Nguyen, Giang, Auf dem Keller, Ulrich, Laustsen, Andreas H, Jenkins, Timothy P

“…Protein structure determination is a critical aspect of biological research, enabling us to understand protein function and potential applications. Recent…”
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Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine by Hulce, Kaitlin R, Jaishankar, Priyadarshini, Lee, Gregory M, Bohn, Markus-Frederik, Connelly, Emily J, Wucherer, Kristin, Ongpipattanakul, Chayanid, Volk, Regan F, Chuo, Shih-Wei, Arkin, Michelle R, Renslo, Adam R, Craik, Charles S

“…Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antivirals address only a fraction of the potential viral human…”
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Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases by Acker, Timothy M, Gable, Jonathan E, Bohn, Markus-Frederik, Jaishankar, Priyadarshini, Thompson, Michael C, Fraser, James S, Renslo, Adam R, Craik, Charles S

“…Targeting of cryptic binding sites represents an attractive but underexplored approach to modulating protein function with small molecules. Using the dimeric…”
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Immunotargeting of Nanocrystals by SpyCatcher Conjugation of Engineered Antibodies by Pedroso, Cassio S., Mann, Victor R., Zuberbühler, Kathrin, Bohn, Markus-Frederik, Yu, Jessica, Altoe, Virginia, Craik, Charles S., Cohen, Bruce E.

“…Inorganic nanocrystals such as quantum dots (QDs) and upconverting nanoparticles (UCNPs) are uniquely suited for quantitative live-cell imaging and are…”
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Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling by Tulika, Tulika, Ruso-Julve, Fulgencio, Ahmadi, Shirin, Ljungars, Anne, Rivera-de-Torre, Esperanza, Wade, Jack, Fernández-Quintero, Monica L, Jenkins, Timothy P, Belfakir, Selma B, Ross, Georgina M S, Boyens-Thiele, Lars, Buell, Alexander K, Sakya, Siri A, Sørensen, Christoffer V, Bohn, Markus-Frederik, Ledsgaard, Line, Voldborg, Bjørn G, Francavilla, Chiara, Schlothauer, Tilman, Lomonte, Bruno, Andersen, Jan Terje, Laustsen, Andreas H

“…Immunoglobulin G (IgG) antibodies that bind their cognate antigen in a pH-dependent manner (acid-switched antibodies) can release their bound antigen for…”
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