Search Results - "Bohn, M C"

Distribution and morphology of the catecholaminergic neural elements in the human hypothalamus by Dudas, B, Baker, M, Rotoli, G, Grignol, G, Bohn, M.C, Merchenthaler, I

“…Abstract Previous studies have demonstrated that catecholaminergic, tyrosine hydroxylase (TH)-immunoreactive (IR) perikarya and fibers are widely distributed…”
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Combining glial cell line-derived neurotrophic factor gene delivery (AdGDNF) with l -arginine decreases contusion size but not behavioral deficits after traumatic brain injury by DeGeorge, M.L, Marlowe, D, Werner, E, Soderstrom, K.E, Stock, M, Mueller, A, Bohn, M.C, Kozlowski, D.A

“…Abstract Our laboratory has previously demonstrated that viral administration of glial cell line-derived neurotrophic factor (AdGDNF), one week prior to a…”
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Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors by Han, Y, Chang, Q A, Virag, T, West, N C, George, D, Castro, M G, Bohn, M C

“…The ability to safely control transgene expression from viral vectors is a long-term goal in the gene therapy field. We have previously reported tight…”
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The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685] by Engele, J, Bohn, MC

“…Neurotrophic support is generally believed to result from a direct action of growth factors on developing neurons. However, there is increasing evidence that…”
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Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats by Morel, G.R, Sosa, Y.E, Bellini, M.J, Carri, N.G, Rodriguez, S.S, Bohn, M.C, Goya, R.G

“…Abstract Progressive dysfunction of hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons during normal aging is associated in the female rat with…”
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Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCR by JIANG, L, RAMPALLI, S, GEORGE, D, PRESS, C, BREMER, E. G, O'GORMAN, M. R. G, BOHN, M. C

“…Vectors suitable for delivery of therapeutic genes to the CNS for chronic neurodegenerative diseases will require regulatable transgene expression. In this…”
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Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats by Smith, A.D., Kozlowski, D.A., Bohn, M.C., Zigmond, M.J.

“…We have previously observed that the delivery of an adenoviral vector encoding for glial cell line-derived neurotrophic factor (AdGDNF) into the substantia…”
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Intramuscular grafts of myoblasts genetically modified to secrete glial cell line-derived neurotrophic factor prevent motoneuron loss and disease progression in a mouse model of familial amyotrophic lateral sclerosis by Mohajeri, M H, Figlewicz, D A, Bohn, M C

“…Effects of ex vivo GDNF gene delivery on the degeneration of motoneurons were studied in the G1H transgenic mouse model of familial ALS carrying a human…”
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Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat by CONNOR, B, KOZLOWSKI, D. A, SCHALLERT, T, TILLERSON, J. L, DAVIDSON, B. L, BOHN, M

“…Injection of an adenoviral (Ad) vector encoding human glial cell line-derived neurotrophic factor (GDNF) protects dopaminergic (DA) neurons in the substantia…”
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Organization of adrenergic inputs to the paraventricular and supraoptic nuclei of the hypothalamus in the rat by Cunningham, Jr, E T, Bohn, M C, Sawchenko, P E

“…Anterograde transport, retrograde transport, and immunohistochemical techniques were used to characterize the organization of neural inputs to the…”
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Quantitative analyses of GFRα-1 and GFRα-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat by Kozlowski, D.A, Miljan, E.A, Bremer, E.G, Harrod, C.G, Gerin, C, Connor, B, George, D, Larson, B, Bohn, M.C

“…Copy numbers of mRNAs for GFRα-1 and GFRα-2, the preferred receptors for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) were determined…”
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Behavioral and Cellular Protection of Rat Dopaminergic Neurons by an Adenoviral Vector Encoding Glial Cell Line-Derived Neurotrophic Factor by Choi-Lundberg, Derek L., Lin, Qing, Schallert, Tim, Crippens, Donita, Davidson, Beverly L., Chang, Yung-Nien, Chiang, Yawen L., Qian, Jiang, Bardwaj, Leena, Bohn, Martha C.

“…Previously, we observed that an adenoviral (Ad) vector encoding human glial cell line-derived neurotrophic factor (GDNF), injected near the rat substantia…”
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Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex by Jara, J H, Stanford, M J, Zhu, Y, Tu, M, Hauswirth, W W, Bohn, M C, DeVries, S H, Özdinler, P H

“…Direct gene delivery to the neurons of interest, without affecting other neuron populations in the cerebral cortex, represent a challenge owing to the…”
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A commentary on glial cell line-derived neurotrophic factor (GDNF): From a glial secreted molecule to gene therapy by Bohn, Martha C.

“…Glial cell line-derived neurotrophic factor (GDNF) was identified as a consequence of the hypothesis that glia secrete factors that influence growth and…”
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Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: role of mesencephalic glia by Engele, J, Schubert, D, Bohn, M C

“…Neuronal differentiation is influenced by extracellular factors; however, only a few such factors have been identified for central neurons. To address this…”
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Small to Medium Contractor Contingency and Assumption of Risk by Smith, Gary R, Bohn, Caryn M

“…This paper is the result of an investigation into the use of contingency in smaller construction firms. It summarizes recent literature classifying…”
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Adenovirus-mediated transgene expression in nonhuman primate brain by Bohn, M C, Choi-Lundberg, D L, Davidson, B L, Leranth, C, Kozlowski, D A, Smith, J C, O'Banion, M K, Redmond, Jr, D E

“…Transgene expression in the brain of St. Kitts green monkey, Cercopithecus aethiops sabeus, was studied following injection of a serotype 5 adenoviral vector…”
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Inflammatory responses and their impact on β-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus by LAWRENCE, M. S, FOELLMER, H. G, ELSWORTH, J. D, KIM, J. H, LERANTH, C, KOZLOWSKI, D. A, BOTHWELL, A. L. M, DAVIDSON, B. L, BOHN, M. C, REDMOND, D. E

“…An E1, E3 deleted adenovirus vector, serotype 5, carrying the marker gene LacZ was bilaterally microinfused into the caudate nuclei of 10 St Kitts green…”
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Association of glucocorticoid receptor immunoreactivity with cell membrane and transport vesicles in hippocampal and hypothalamic neurons of the rat by Liposits, Z, Bohn, M C

“…The aim of the present study was to reveal at the ultrastructural level cytoplasmic loci that display glucocorticoid receptor (GR) immunoreactivity in…”
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Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson's disease by Yoshimoto, Yusuke, Lin, Qing, Collier, Timothy J., Frim, David M., Breakefield, Xandra O., Bohn, Martha C.

“…Neurotrophic factors that improve the survival of specific neuronal types during development and after exposure to various neuronal insults hold potential for…”
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