Search Results - "Bohn, M"

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism by Luttrell, Louis M, Maudsley, Stuart, Bohn, Laura M

“…The fact that over 30% of current pharmaceuticals target heptahelical G protein-coupled receptors (GPCRs) attests to their tractability as drug targets…”
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Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics by Grim, Travis W., Acevedo-Canabal, Agnes, Bohn, Laura M.

“…The mu opioid receptor (MOR) is a diversely regulated target for the alleviation of pain in the clinical setting. However, untoward side effects such as…”
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Crystal Structure of the Human Cannabinoid Receptor CB1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of…”
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Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics by Schmid, Cullen L., Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Morgenweck, Jenny, Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

“…Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein,…”
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Crystal Structure of the Human Cannabinoid Receptor CB2 by Li, Xiaoting, Hua, Tian, Vemuri, Kiran, Ho, Jo-Hao, Wu, Yiran, Wu, Lijie, Popov, Petr, Benchama, Othman, Zvonok, Nikolai, Locke, K’ara, Qu, Lu, Han, Gye Won, Iyer, Malliga R., Cinar, Resat, Coffey, Nathan J., Wang, Jingjing, Wu, Meng, Katritch, Vsevolod, Zhao, Suwen, Kunos, George, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic…”
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Crystal structures of agonist-bound human cannabinoid receptor CB1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Crystal structures of the human cannabinoid receptor 1 (CB 1 ) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor…”
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Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures by Hua, Tian, Li, Xiaoting, Wu, Lijie, Iliopoulos-Tsoutsouvas, Christos, Wang, Yuxia, Wu, Meng, Shen, Ling, Brust, Christina A., Nikas, Spyros P., Song, Feng, Song, Xiyong, Yuan, Shuguang, Sun, Qianqian, Wu, Yiran, Jiang, Shan, Grim, Travis W., Benchama, Othman, Stahl, Edward L., Zvonok, Nikolai, Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Liu, Zhi-Jie

“…Human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors CB1 and CB2. Their high sequence…”
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The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics by Raehal, Kirsten M., Bohn, Laura M.

“…Ligands acting at the same receptor can differentially activate distinct signal transduction pathways, which in turn, can have diverse functional consequences…”
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Community guidelines for GPCR ligand bias: IUPHAR review 32 by Kolb, Peter, Kenakin, Terry, Alexander, Stephen P. H., Bermudez, Marcel, Bohn, Laura M., Breinholt, Christian S., Bouvier, Michel, Hill, Stephen J., Kostenis, Evi, Martemyanov, Kirill A., Neubig, Rick R., Onaran, H. Ongun, Rajagopal, Sudarshan, Roth, Bryan L., Selent, Jana, Shukla, Arun K., Sommer, Martha E., Gloriam, David E.

“…GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third of FDA‐approved drugs. Depending on which ligand activates a…”
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Zinc-Assisted Hydrodeoxygenation of Biomass-Derived 5-Hydroxymethylfurfural to 2,5-Dimethylfuran by Saha, Basudeb, Bohn, Christine M., Abu-Omar, Mahdi M.

“…2,5‐Dimethylfuran (DMF), a promising cellulosic biofuel candidate from biomass derived intermediates, has received significant attention because of its low…”
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Functional selectivity of GPCR signaling in animals by Zhou, Lei, Bohn, Laura M

“…Graphical abstract…”
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Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

“…Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and…”
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An evaluation of Mg/Ca, Sr/Ca, and Ba/Ca ratios as environmental proxies in aragonite bivalve shells by Poulain, C., Gillikin, D.P., Thébault, J., Munaron, J.M., Bohn, M., Robert, R., Paulet, Y.-M., Lorrain, A.

“…The influence of salinity and water chemistry on Mg/Ca, Sr/Ca, and Ba/Ca ratios in the aragonitic shells of the Manila clam was investigated. Clams were reared…”
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U–Th stratigraphy of a cold seep carbonate crust by Bayon, G., Henderson, G.M., Bohn, M.

“…On continental margins, oxidation of methane-rich fluids from the sediment often leads to formation of authigenic carbonate pavements on the seafloor. The…”
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Desensitization of G protein-coupled receptors and neuronal functions by GAINETDINOV, Raul R, PREMONT, Richard T, BOHN, Laura M, LEFKOWITZ, Robert J, CARON, Marc G

“…G protein-coupled receptors (GPCRs) have proven to be the most highly favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are…”
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Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo by Schmid, Cullen L, Raehal, Kirsten M, Bohn, Laura M

“…Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as schizophrenia, and they also can be induced by the use or abuse of…”
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Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain by Pantouli, Fani, Grim, Travis W., Schmid, Cullen L., Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

“…The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays, thereby…”
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Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors by Zhou, Lei, Lovell, Kimberly M., Frankowski, Kevin J., Slauson, Stephen R., Phillips, Angela M., Streicher, John M., Stahl, Edward, Schmid, Cullen L., Hodder, Peter, Madoux, Franck, Cameron, Michael D., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.

“…The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means to modulate pain perception, stress responses, and affective reward…”
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Angiogenesis imaging study using interim [18F] RGD-K5 PET/CT in patients with lymphoma undergoing chemotherapy: preliminary evidence by Tonnelet, David, Bohn, M. D. Pierre, Becker, Stephanie, Decazes, Pierre, Camus, Vincent, Thureau, Sebastien, Tilly, Hervé, Jardin, Fabrice, Vera, Pierre

“…Background Our aim was to measure the impact of two cycles of standard chemotherapy on tumoural neoangiogenesis by [ 18 F] fluorine arginine-glycine-aspartic…”
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Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity by Sevillano, N., Bohn, M.F., Zimanyi, M., Chen, Y., Petzold, C., Gupta, S., Ralston, C.Y., Craik, C.S.

“…Affinity maturation of U33, a recombinant Fab inhibitor of uPA, was used to improve the affinity and the inhibitory effect compared to the parental Fab…”
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