Search Results - "Bohn, Laura M"

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  1. 1

    Crystal Structure of the Human Cannabinoid Receptor CB1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

    Published in Cell (20-10-2016)
    “…Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of…”
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  2. 2

    Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism by Luttrell, Louis M, Maudsley, Stuart, Bohn, Laura M

    Published in Molecular pharmacology (01-09-2015)
    “…The fact that over 30% of current pharmaceuticals target heptahelical G protein-coupled receptors (GPCRs) attests to their tractability as drug targets…”
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  3. 3

    Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics by Grim, Travis W., Acevedo-Canabal, Agnes, Bohn, Laura M.

    Published in Biological psychiatry (1969) (01-01-2020)
    “…The mu opioid receptor (MOR) is a diversely regulated target for the alleviation of pain in the clinical setting. However, untoward side effects such as…”
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  4. 4

    Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics by Schmid, Cullen L., Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Morgenweck, Jenny, Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

    Published in Cell (16-11-2017)
    “…Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein,…”
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  5. 5

    Crystal structures of agonist-bound human cannabinoid receptor CB1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

    Published in Nature (London) (27-07-2017)
    “…Crystal structures of the human cannabinoid receptor 1 (CB 1 ) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor…”
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    Crystal Structure of the Human Cannabinoid Receptor CB2 by Li, Xiaoting, Hua, Tian, Vemuri, Kiran, Ho, Jo-Hao, Wu, Yiran, Wu, Lijie, Popov, Petr, Benchama, Othman, Zvonok, Nikolai, Locke, K’ara, Qu, Lu, Han, Gye Won, Iyer, Malliga R., Cinar, Resat, Coffey, Nathan J., Wang, Jingjing, Wu, Meng, Katritch, Vsevolod, Zhao, Suwen, Kunos, George, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

    Published in Cell (24-01-2019)
    “…The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic…”
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    The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics by Raehal, Kirsten M., Bohn, Laura M.

    Published in Neuropharmacology (01-01-2011)
    “…Ligands acting at the same receptor can differentially activate distinct signal transduction pathways, which in turn, can have diverse functional consequences…”
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  11. 11

    Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

    Published in Science signaling (29-11-2016)
    “…Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and…”
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  12. 12

    Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo by Schmid, Cullen L, Raehal, Kirsten M, Bohn, Laura M

    “…Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as schizophrenia, and they also can be induced by the use or abuse of…”
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  13. 13

    Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain by Pantouli, Fani, Grim, Travis W., Schmid, Cullen L., Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

    Published in Neuropharmacology (01-03-2021)
    “…The mu opioid receptor-selective agonist, SR-17018, preferentially activates GTPγS binding over βarrestin2 recruitment in cellular assays, thereby…”
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    5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking by You, In-Jee, Wright, Sherie R, Garcia-Garcia, Alvaro L, Tapper, Andrew R, Gardner, Paul D, Koob, George F, David Leonardo, E, Bohn, Laura M, Wee, Sunmee

    Published in Neuropsychopharmacology (New York, N.Y.) (01-04-2016)
    “…Cocaine addiction and depression are comorbid disorders. Although it is well recognized that 5-hydroxytryptamine (5-HT; serotonin) plays a central role in…”
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  16. 16

    Desensitization of G protein-coupled receptors and neuronal functions by GAINETDINOV, Raul R, PREMONT, Richard T, BOHN, Laura M, LEFKOWITZ, Robert J, CARON, Marc G

    Published in Annual review of neuroscience (01-01-2004)
    “…G protein-coupled receptors (GPCRs) have proven to be the most highly favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs are…”
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  17. 17

    A Route to Potent, Selective, and Biased Salvinorin Chemical Space by Hill, Sarah J., Dao, Nathan, Dang, Vuong Q., Stahl, Edward L., Bohn, Laura M., Shenvi, Ryan A.

    Published in ACS central science (23-08-2023)
    “…The salvinorins serve as templates for next generation analgesics, antipruritics, and dissociative hallucinogens via selective and potent agonism of the…”
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  18. 18

    Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine by Acevedo-Canabal, Agnes, Grim, Travis W, Schmid, Cullen L, McFague, Nina, Stahl, Edward L, Kennedy, Nicole M, Bannister, Thomas D, Bohn, Laura M

    Published in Biomolecules (Basel, Switzerland) (01-06-2023)
    “…Opioid analgesics such as morphine and fentanyl induce mu-opioid receptor (MOR)-mediated hyperactivity in mice. Herein, we show that morphine, fentanyl,…”
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    GIRK channel modulation by assembly with allosterically regulated RGS proteins by Zhou, Hao, Chisari, Mariangela, Raehal, Kirsten M, Kaltenbronn, Kevin M, Bohn, Laura M, Mennerick, Steven J, Blumer, Kendall J

    “…G-protein–activated inward-rectifying K ⁺ (GIRK) channels hyperpolarize neurons to inhibit synaptic transmission throughout the nervous system. By accelerating…”
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  20. 20

    Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer by Wang, Danxin, Sun, Xiaochun, Bohn, Laura M, Sadée, Wolfgang

    Published in Molecular pharmacology (01-06-2005)
    “…Opioid receptors have been shown to dimerize or oligomerize among themselves and each other, affecting their functional properties. This study used…”
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