Search Results - "Bohmig, G. A."

The Effect of Cortex/Medulla Proportions on Molecular Diagnoses in Kidney Transplant Biopsies: Rejection and Injury Can Be Assessed in Medulla by Madill‐Thomsen, K. S., Wiggins, R. C., Eskandary, F., Böhmig, G. A., Halloran, P. F.

“…Histologic assessment of kidney transplant biopsies relies on cortex rather than medulla, but for microarray studies, the proportion cortex in a biopsy is…”
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Effect of the Anti‐C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody–Induced Complement Activation—A Preclinical In Vitro Study by Wahrmann, M., Mühlbacher, J., Marinova, L., Regele, H., Huttary, N., Eskandary, F., Cohen, G., Fischer, G. F., Parry, G. C., Gilbert, J. C., Panicker, S., Böhmig, G. A.

“…The classic pathway (CP) of complement is believed to significantly contribute to alloantibody‐mediated transplant injury, and targeted complement inhibition…”
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Value of Routine Voiding Cystourethrography After Renal Transplantation by Margreiter, M., Györi, G. P., Böhmig, G. A., Trubel, S., Mühlbacher, F., Steininger, R.

“…The impact of vesicoureteral reflux (VUR) on renal allograft outcomes is debatable, with small cohort studies reporting controversial results. The objective of…”
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Anti‐inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL‐12 and up‐regulation of IL‐10 production by Säemann, Marcus D., Böhmig, Georg A., Österreicher, Christoph H., Burtscher, Helmut, Parolini, Ornella, Diakos, Christos, Stöckl, Johannes, Hörl, Walter H., Zlabinger, Gerhard J.

“…ABSTRACT Cytokines are critical in regulating unresponsiveness versus immunity towards enteric antigens derived from the intestinal flora and ingested food…”
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Real Time Central Assessment of Kidney Transplant Indication Biopsies by Microarrays: The INTERCOMEX Study by Halloran, P. F., Reeve, J., Akalin, E., Aubert, O., Bohmig, G. A., Brennan, D., Bromberg, J., Einecke, G., Eskandary, F., Gosset, C., Duong Van Huyen, J.‐P., Gupta, G., Lefaucheur, C., Malone, A., Mannon, R. B., Seron, D., Sellares, J., Weir, M., Loupy, A.

“…The authors conducted a prospective trial to assess the feasibility of real time central molecular assessment of kidney transplant biopsy samples from 10 North…”
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Immunoadsorption in Severe C4d‐Positive Acute Kidney Allograft Rejection: A Randomized Controlled Trial by Böhmig, G. A., Wahrmann, M., Regele, H., Exner, M., Robl, B., Derfler, K., Soliman, T., Bauer, P., Müllner, M., Druml, W.

“…Antibody‐mediated rejection (AMR) frequently causes refractory graft dysfunction. This randomized controlled trial was designed to evaluate whether…”
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Peritransplant Immunoadsorption for Positive Crossmatch Deceased Donor Kidney Transplantation by Bartel, G., Wahrmann, M., Regele, H., Kikić, Ž., Fischer, G., Druml, W., Mühlbacher, F., Böhmig, G. A.

“…Various desensitization protocols were shown to enable successful living donor kidney transplantation across a positive complement‐dependent cytotoxicity…”
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The Cellular Lesion of Humoral Rejection: Predominant Recruitment of Monocytes to Peritubular and Glomerular Capillaries by Fahim, T., Böhmig, G. A., Exner, M., Huttary, N., Kerschner, H., Kandutsch, S., Kerjaschki, D., Bramböck, A., Nagy‐Bojarszky, K., Regele, H.

“…Accumulation of inflammatory cells within capillaries is a common morphologic feature of humoral renal allograft rejection and is most easily appreciated if it…”
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Posttransplant HLA Alloreactivity in Stable Kidney Transplant Recipients—Incidences and Impact on Long‐Term Allograft Outcomes by Bartel, G., Regele, H., Wahrmann, M., Huttary, N., Exner, M., Hörl, W. H., Böhmig, G. A.

“…Humoral alloreactivity is well established to predict adverse allograft outcomes. However, in some recipients, alloantibodies may also occur in the absence of…”
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In Vitro Detection of C4d‐Fixing HLA Alloantibodies: Associations With Capillary C4d Deposition in Kidney Allografts by Bartel, G., Wahrmann, M., Exner, M., Regele, H., Huttary, N., Schillinger, M., Körmöczi, G. F., Hörl, W. H., Böhmig, G. A.

“…Capillary C4d deposition is a valuable marker of antibody‐mediated rejection (AMR). In this analysis, flow cytometric detection of alloantibody‐triggered C4d…”
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Pivotal Role of Complement‐Fixing HLA Alloantibodies in Presensitized Kidney Allograft Recipients by Wahrmann, M., Exner, M., Schillinger, M., Haidbauer, B., Regele, H., Körmöczi, G. F., Hörl, W. H., Böhmig, G. A.

“…Recipient presensitization represents a major risk factor for kidney allograft loss. Complement fixation may be a critical attribute of deleterious…”
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Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection by REGELE, Heinz, BÖHMIG, Georg A, HABICHT, Antje, GOLLOWITZER, Daniela, SCHILLINGER, Martin, ROCKENSCHAUB, Susanne, WATSCHINGER, Bruno, KERJASCHKI, Dontscho, EXNER, Markus

“…Endothelial deposition of the complement split product C4d is an established marker of antibody-mediated acute renal allograft rejection. A contribution of…”
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Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection by Regele, Heinz, Exner, Markus, Watschinger, Bruno, Wenter, Christian, Wahrmann, Markus, Österreicher, Christoph, Säemann, Marcus D., Mersich, Nicole, Hörl, Walter H., Zlabinger, Gerhard J., Böhmig, Georg A.

“…Background. Capillary deposition of complement split product C4d has been suggested to be a valuable marker for humoral rejection. In this retrospective study…”
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C4d-positive acute humoral renal allograft rejection : Effective treatment by immunoadsorption by BÖHMIG, Georg A, REGELE, Heinz, EXNER, Markus, DERHARTUNIAN, Victor, KLETZMAYR, Josef, SÄEMANN, Marcus D, HÖRL, Walter H, DRUML, Wilfred, WATSCHINGER, Bruno

“…There is increasing evidence for an important pathogenetic role of alloantibodies in acute renal allograft rejection. Acute humoral rejection (AHR) has been…”
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Functional Fc gamma receptor gene polymorphisms and donor‐specific antibody‐triggered microcirculation inflammation by Arnold, M. L., Kainz, A., Hidalgo, L. G., Eskandary, F., Kozakowski, N., Wahrmann, M., Haslacher, H., Oberbauer, R., Heilos, A., Spriewald, B. M., Halloran, P. F., Böhmig, G. A.

“…Fc‐dependent effector mechanisms may contribute to antibody‐mediated rejection (ABMR), and distinct gene polymorphisms modifying the function of Fc gamma…”
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Donor heme oxygenase-1 genotype is associated with renal allograft function by EXNER, Markus, BOHMIG, Georg A, SCHILLINGER, Martin, REGELE, Heinz, WATSCHINGER, Bruno, HÖRL, Walter H, RAITH, Marianne, MANNHALTER, Christine, WAGNER, Oswald F

“…The heme oxygenase (HO) isoenzyme HO-1 has recently been suggested to protect transplants from ischemia/reperfusion and immunologic injury. Inducibility of…”
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Anti‐C1s monoclonal antibody BIVV009 in late antibody‐mediated kidney allograft rejection—results from a first‐in‐patient phase 1 trial by Eskandary, F., Jilma, B., Mühlbacher, J., Wahrmann, M., Regele, H., Kozakowski, N., Firbas, C., Panicker, S., Parry, G. C., Gilbert, J. C., Halloran, P. F., Böhmig, G. A.

“…The classical pathway (CP) of complement may contribute to the pathogenesis of antibody‐mediated rejection (ABMR). Selective CP blockade may be a promising…”
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[C4d]FlowPRA Screening—A Specific Assay for Selective Detection of Complement-Activating Anti-HLA Alloantibodies by Wahrmann, Markus, Exner, Markus, Haidbauer, Bettina, Schillinger, Martin, Regele, Heinz, Körmöczi, Günther, Böhmig, Georg A.

“…On waiting lists, transplant candidates are routinely screened for potentially harmful complement-fixing alloantibodies using complement-dependent cytotoxicity…”
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Risk factors for capillary C4d deposition in kidney allografts: Evaluation of a large study cohort by LORENZ, Matthias, REGELE, Heinz, SCHILLINGER, Martin, EXNER, Markus, RASOUL-ROCKENSCHAUB, Susanne, WAHRMANN, Markus, KLETZMAYR, Josef, SILBERHUMER, Gerd, HÖRL, Walter H, BÖHMIG, Georg A

“…Capillary deposition of the complement split product C4d has turned out to be a valuable marker of antibody-mediated rejection. The impact of pre- and…”
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The Source Matters: No Impact of the CCL2/MCP-1-1-2518G Polymorphism of the Donor on Renal Allograft Outcome During the First Year After Transplantation by Lehmann, I, Fischereder, M, Böhmig, G.A, Regele, H, Exner, M, Raith, M, Weiss, N, Segerer, S

“…Abstract Chemokines are involved in the recruitment of inflammatory cells to vascularized allografts. The chemokine CCL2/MCP-1 is expressed during allograft…”
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