Search Results - "Bohmer, Frank D"

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ by Godfrey, Rinesh, Arora, Deepika, Bauer, Reinhard, Stopp, Sabine, Müller, Jörg P., Heinrich, Theresa, Böhmer, Sylvia-Annette, Dagnell, Markus, Schnetzke, Ulf, Scholl, Sebastian, Östman, Arne, Böhmer, Frank-D.

“…Signal transduction of FMS-like tyrosine kinase 3 (FLT3) is regulated by protein-tyrosine phosphatases (PTPs). We recently identified the PTP DEP-1/CD148/PTPRJ…”
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Regulation of Receptor Tyrosine Kinase Signaling by Protein Tyrosine Phosphatase-1B by Haj, Fawaz G., Markova, Boyka, Klaman, Lori D., Bohmer, Frank D., Neel, Benjamin G.

“…Receptor tyrosine kinases (RTKs) are key regulators of cellular homeostasis. Based on in vitro andex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was…”
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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy by Schmidt-Arras, Dirk, Böhmer, Frank-D.

“…Activating mutations in genes encoding receptor tyrosine kinases (RTKs) mediate proliferation, cell migration, and cell survival, and are therefore important…”
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Regulation of protein tyrosine phosphatases by reversible oxidation by Östman, Arne, Frijhoff, Jeroen, Sandin, Åsa, Böhmer, Frank-D.

“…Oxidation of the catalytic cysteine of protein-tyrosine phosphatases (PTP), which leads to their reversible inactivation, has emerged as an important…”
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Transactivation joins multiple tracks to the ERK/MAPK cascade by Wetzker, Reinhard, Böhmer, Frank-D

“…Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase…”
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Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase:  Structure−Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins by Gazit, Aviv, App, Harald, McMahon, Gerald, Chen, Jefferey, Levitzki, Alexander, Bohmer, Frank D

“…A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived…”
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NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML by Jayavelu, Ashok Kumar, Moloney, Jennifer N, Böhmer, Frank-D, Cotter, Thomas G

“…In different types of myeloid leukemia, increased formation of reactive oxygen species (ROS) has been noted and associated with aspects of cell transformation,…”
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The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals by Karagyozov, Luchezar, Grozdanov, Petar N, Böhmer, Frank-D

“…The signal peptides, present at the N-terminus of many proteins, guide the proteins into cell membranes. In some proteins, the signal peptide is with an…”
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Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes by TCHAIKOVSKI, Vadim, OLIESLAGERS, Servé, BÖHMER, Frank-D, WALTENBERGER, Johannes

“…Monocytes are cellular components of wound repair, arteriogenesis, and atherogenesis. Vascular endothelial growth factor (VEGF)-A and placental growth factor…”
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Protein-tyrosine phosphatases and cancer by Böhmer, Frank D, Östman, Arne, Hellberg, Carina

“…Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and…”
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SHP1 regulates a STAT6–ITGB3 axis in FLT3ITD-positive AML cells by Reich, Daniela, Kresinsky, Anne, Müller, Jörg P., Bauer, Reinhard, Kallenbach, Julia, Schnoeder, Tina M., Heidel, Florian H., Fässler, Reinhard, Mann, Matthias, Böhmer, Frank-D., Jayavelu, Ashok Kumar

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Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis by Dorenkamp, Marc, Müller, Jörg P., Shanmuganathan, Kallipatti Sanjith, Schulten, Henny, Müller, Nicolle, Löffler, Ivonne, Müller, Ulrich A., Wolf, Gunter, Böhmer, Frank-D., Godfrey, Rinesh, Waltenberger, Johannes

“…Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte…”
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Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes by Choudhary, Chunaram, Olsen, Jesper V., Brandts, Christian, Cox, Jürgen, Reddy, Pavankumar N.G., Böhmer, Frank D., Gerke, Volker, Schmidt-Arras, Dirk-E., Berdel, Wolfgang E., Müller-Tidow, Carsten, Mann, Matthias, Serve, Hubert

“…Inappropriate activation of oncogenic kinases at intracellular locations is frequently observed in human cancers, but its effects on global signaling are…”
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Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics by Kellner, Fabienne, Keil, Andreas, Schindler, Katrin, Tschongov, Todor, Hünninger, Kerstin, Loercher, Hannah, Rhein, Peter, Böhmer, Sylvia‐Annette, Böhmer, Frank‐D., Müller, Jörg P.

“…Class III receptor tyrosine kinases control the development of hematopoietic stem cells. Constitutive activation of FLT3 by internal tandem duplications (ITD)…”
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A phosphorylation-acetylation switch regulates STAT1 signaling by Krämer, Oliver H, Knauer, Shirley K, Greiner, Georg, Jandt, Enrico, Reichardt, Sigrid, Gührs, Karl-Heinz, Stauber, Roland H, Böhmer, Frank D, Heinzel, Thorsten

“…Cytokines such as interferons (IFNs) activate signal transducers and activators of transcription (STATs) via phosphorylation. Histone deacetylases (HDACs) and…”
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Activation mechanisms of STAT5 by oncogenic Flt3-ITD by Choudhary, Chunaram, Brandts, Christian, Schwable, Joachim, Tickenbrock, Lara, Sargin, Bülent, Ueker, Andrea, Böhmer, Frank-D., Berdel, Wolfgang E., Müller-Tidow, Carsten, Serve, Hubert

“…Mutations in the receptor tyrosine kinase Flt3 represent a very common genetic lesion in acute myeloid leukemia (AML). Internal tandem duplication (ITD)…”
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Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation by Kresinsky, Anne, Schnöder, Tina M., Jacobsen, Ilse D., Rauner, Martina, Hofbauer, Lorenz C., Ast, Volker, König, Rainer, Hoffmann, Bianca, Svensson, Carl-Magnus, Figge, Marc Thilo, Hilger, Ingrid, Heidel, Florian H., Böhmer, Frank- D., Müller, Jörg P.

“…The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Activating mutations in FLT3 occur in 25–30% of acute myeloid…”
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The protein‐tyrosine phosphatase DEP‐1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase by Schneble, Nadine, Müller, Julia, Kliche, Stefanie, Bauer, Reinhard, Wetzker, Reinhard, Böhmer, Frank‐D., Wang, Zhao‐Qi, Müller, Jörg P.

“…Microglia cells are brain macrophages whose proper functioning is essential for maintenance and repair processes of the central nervous system (CNS). Migration…”
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Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3 -ITD acute myeloid leukemia by Kresinsky, Anne, Bauer, Reinhard, Schnöder, Tina M, Berg, Tobias, Meyer, Daria, Ast, Volker, König, Rainer, Serve, Hubert, Heidel, Florian H, Böhmer, Frank-D, Müller, Jörg P

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Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation by Böhmer, Annette, Barz, Saskia, Schwab, Katjana, Kolbe, Ulrike, Gabel, Anke, Kirkpatrick, Joanna, Ohlenschläger, Oliver, Görlach, Matthias, Böhmer, Frank-D.

“…Oxidative modification of cysteine residues has been shown to regulate the activity of several protein-tyrosine kinases. We explored the possibility that…”
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