Search Results - "Bohlander, S."

Early assessment of minimal residual disease in AML by flow cytometry during aplasia identifies patients at increased risk of relapse by Köhnke, T, Sauter, D, Ringel, K, Hoster, E, Laubender, R P, Hubmann, M, Bohlander, S K, Kakadia, P M, Schneider, S, Dufour, A, Sauerland, M-C, Berdel, W E, Büchner, T, Wörmann, B, Braess, J, Hiddemann, W, Spiekermann, K, Subklewe, M

“…In acute myeloid leukemia (AML), assessment of minimal residual disease (MRD) by flow cytometry (flow MRD) after induction and consolidation therapy has been…”
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BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts by KOHL, T. M, HELLINGER, C, AHMED, F, BUSKE, C, HIDDEMANN, W, BOHLANDER, S. K, SPIEKERMANN, K

“…FLT3 defines a promising target for the treatment of acute myeloid leukemia (AML). In contrast to their efficacy in cell lines, FLT3-specific inhibitors as…”
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P438: ARYL HYDROCARBON RECEPTOR SIGNALLING IN NORMAL HAEMATOPOIETIC (HSC) AND LEUKEMIA STEM CELLS (LSC): DIFFERENTIAL EFFECT OF AHR ANTAGONIST ON LSC COMPARED TO HSC by Oryshchuk, A., Desai, R., Kakadiya, P., Bohlander, S.

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Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia by Konstandin, N, Bultmann, S, Szwagierczak, A, Dufour, A, Ksienzyk, B, Schneider, F, Herold, T, Mulaw, M, Kakadia, P M, Schneider, S, Spiekermann, K, Leonhardt, H, Bohlander, S K

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A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients by Beck, D, Thoms, J A I, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, B J, Schwarzer, A, Klusmann, J-H, Berdel, W E, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, S K, To, L B, Scott, H S, Lewis, I D, D'Andrea, R J, Wong, J W H, Pimanda, J E

“…Prognostic gene expression signatures have been proposed as clinical tools to clarify therapeutic options in acute myeloid leukemia (AML). However, these…”
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An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia by Herold, T, Jurinovic, V, Metzeler, K H, Boulesteix, A-L, Bergmann, M, Seiler, T, Mulaw, M, Thoene, S, Dufour, A, Pasalic, Z, Schmidberger, M, Schmidt, M, Schneider, S, Kakadia, P M, Feuring-Buske, M, Braess, J, Spiekermann, K, Mansmann, U, Hiddemann, W, Buske, C, Bohlander, S K

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Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing by Greif, P A, Eck, S H, Konstandin, N P, Benet-Pagès, A, Ksienzyk, B, Dufour, A, Vetter, A T, Popp, H D, Lorenz-Depiereux, B, Meitinger, T, Bohlander, S K, Strom, T M

“…Genetic lesions are crucial for cancer initiation. Recently, whole genome sequencing, using next generation technology, was used as a systematic approach to…”
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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12 by Mulaw, M A, Krause, A J, Deshpande, A J, Krause, L F, Rouhi, A, La Starza, R, Borkhardt, A, Buske, C, Mecucci, C, Ludwig, W-D, Lottaz, C, Bohlander, S K

“…The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute…”
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Elevated PIN1 expression by C EBPα-p30 blocks C EBPα-induced granulocytic differentiation through c-Jun in AML by Pulikkan, J A, Dengler, V, Peer Zada, A A, Kawasaki, A, Geletu, M, Pasalic, Z, Bohlander, S K, Ryo, A, Tenen, D G, Behre, G

“…The transcription factor CCAAT enhancer-binding protein α (C/EBPα) has an important role in granulopoiesis. The tumor suppressor function of C/EBPα is shown by…”
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The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice by Deshpande, A J, Rouhi, A, Lin, Y, Stadler, C, Greif, P A, Arseni, N, Opatz, S, Quintanilla-Fend, L, Holzmann, K, Hiddemann, W, Döhner, K, Döhner, H, Xu, G, Armstrong, S A, Bohlander, S K, Buske, C

“…The t(10;11)(p13-14;q14-21) translocation, giving rise to the CALM–AF10 fusion gene, is a recurrent chromosomal rearrangement observed in patients with poor…”
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CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice by Lange, A P, Almeida, L Y, Araújo Silva, C L, Scheucher, P S, Chahud, F, Krause, A, Bohlander, S K, Rego, E M

“…Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed…”
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Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing by Greif, P A, Yaghmaie, M, Konstandin, N P, Ksienzyk, B, Alimoghaddam, K, Ghavamzadeh, A, Hauser, A, Graf, A, Krebs, S, Blum, H, Bohlander, S K

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The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models by Dutta, S, Krause, A, Vosberg, S, Herold, T, Ksienzyk, B, Quintanilla-Martinez, L, Tizazu, B, Chopra, M, Graf, A, Krebs, S, Blum, H, Greif, P A, Vetter, A, Metzeler, K, Rothenberg-Thurley, M, Schneider, M R, Dahlhoff, M, Spiekermann, K, Zimber-Strobl, U, Wolf, E, Bohlander, S K

“…The CALM/AF10 fusion gene is found in various hematological malignancies including acute myeloid leukemia (AML), T-cell acute lymphoblastic leukemia and…”
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The leukemogenic CALM AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros by Greif, P A, Tizazu, B, Krause, A, Kremmer, E, Bohlander, S K

“…The t(10;11)(p13;q14) translocation leads to the fusion of the CALM and AF10 genes. This translocation can be found as the sole cytogenetic abnormality in…”
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The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia by Thoene, S, Rawat, V P S, Heilmeier, B, Hoster, E, Metzeler, K H, Herold, T, Hiddemann, W, Gökbuget, N, Hoelzer, D, Bohlander, S K, Feuring-Buske, M, Buske, C

“…Molecular characterization of acute lymphoblastic leukemia (ALL) has greatly improved the ability to categorize and prognostify patients with this disease. In…”
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ETV6: A versatile player in leukemogenesis by Bohlander, Stefan K.

“…Alterations of the ets family transcription factor ETV6 ( TEL) and the RUNT domain transcription factor RUNX1 ( AML1) play pivotal roles in the leukemogenesis…”
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Proteomics of acute myeloid leukaemia: cytogenetic risk groups differ specifically in their proteome, interactome and post-translational protein modifications by BALKHI, M. Y, TRIVEDI, A. K, GELETU, M, CHRISTOPEIT, M, BOHLANDER, S. K, BEHRE, H. M, BEHRE, G

“…Acute myeloid leukaemia (AML) is characterized by specific cytogenetic aberrations that are strong determinants of prognostic outcome and therapeutic response…”
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P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA‐TREATED MDS AND CMML by Schnegg‐Kaufmann, A., Thoms, J., Bhuyan, G. S., Henry, H., Vaughan, L., Rutherford, K., Kakadia, P., Johansson, E., Failes, T., Greg, A., Koval, J., Lindeman, R., Warburton, P., Rodriguez‐Meira, A., Mead, A., Unnikrishnan, A., Bohlander, S., Pappaemmanuil, E., Faridani, O., Jolly, C., Zanini, F., Pimanda, J.

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Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C EBPα by Bararia, D, Trivedi, A K, Zada, A A Peer, Greif, P A, Mulaw, M A, Christopeit, M, Hiddemann, W, Bohlander, S K, Behre, G

“…The transcription factor C/EBPα (CEBPA) is a key player in granulopoiesis and leukemogenesis. We have previously reported the interaction of C/EBPα with other…”
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A novel ABL1 fusion to the SH2 containing inositol phosphatase-1 (SHIP1) in acute lymphoblastic leukemia (ALL) by Kakadia, P M, Tizazu, B, Mellert, G, Harbott, J, Röttgers, S, Quentmeier, H, Spiekermann, K, Bohlander, S K

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