Search Results - "Bohannon, Diana G."

Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection by Bohannon, Diana G, Ko, Allen, Filipowicz, Adam R, Kuroda, Marcelo J, Kim, Woong-Ki

“…Impairment of the blood-brain barrier (BBB) has been associated with cognitive decline in many CNS diseases, including HIV-associated neurocognitive disorders…”
Get full text

Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases by Bohannon, Diana G, Long, Danielle, Kim, Woong-Ki

“…Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell…”
Get full text

Perivascular macrophages in the neonatal macaque brain undergo massive necroptosis after simian immunodeficiency virus infection by Bohannon, Diana G., Wang, Yueying, Reinhart, Colin H., Hattler, Julian B., Luo, Jiangtao, Okhravi, Hamid R., Zhang, Jianshui, Li, Qingsheng, Kuroda, Marcelo J., Kim, Jayoung, Kim, Woong‐Ki

“…We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low…”
Get full text

Type-1-to-type-2 transition of brain microvascular pericytes induced by cytokines and disease-associated proteins: Role in neuroinflammation and blood-brain barrier disruption by Bohannon, Diana G, Wellman, Laurie L, Kaul, Marcus, Galkina, Elena V, Guo, Ming-Lei, Datta, Prasun K, Kim, Woong-Ki

“…While the concept of pericyte heterogeneity in the brain microvasculature is becoming more widely accepted, little is known about how they arise, or their…”
Get full text

CSF1R inhibition depletes brain macrophages and reduces brain virus burden in SIV-infected macaques by Bohannon, Diana G, Zablocki-Thomas, Laurent D, Leung, Evan S, Dupont, Jinbum K, Hattler, Julian B, Kowalewska, Jolanta, Zhao, Miaoyun, Luo, Jiangtao, Salemi, Marco, Amedee, Angela M, Li, Qingsheng, Kuroda, Marcelo J, Kim, Woong-Ki

“…Perivascular macrophages (PVMs) and, to a lesser degree, microglia are targets and reservoirs of HIV and simian immunodeficiency virus (SIV) in the brain…”
Get full text

A subtype of cerebrovascular pericytes is associated with blood-brain barrier disruption that develops during normal aging and simian immunodeficiency virus infection by Bohannon, Diana G., Okhravi, Hamid R., Kim, Jayoung, Kuroda, Marcelo J., Didier, Elizabeth S., Kim, Woong-Ki

“…Lax phenotypic characterization of these morphologically distinct pericytes has delayed our understanding of their role in neurological disorders. We herein…”
Get full text

Functionally distinct pericyte subsets differently regulate amyloid-β deposition in patients with Alzheimer's disease by Bohannon, Diana G, Long, Danielle, Okhravi, Hamid R, Lee, Sunhee C, De Jesus, Christopher Lawrence, Neubert, Thomas A, Rostagno, Agueda A, Ghiso, Jorge A, Kim, Woong-Ki

“…Although the concept that the blood-brain barrier (BBB) plays an important role in the etiology and pathogenesis of Alzheimer's disease (AD) has become…”
Get full text

A Zika virus primary isolate induces neuroinflammation, compromises the blood‐brain barrier and upregulates CXCL12 in adult macaques by Panganiban, Antonito T., Blair, Robert V., Hattler, Julian B., Bohannon, Diana G., Bonaldo, Myrna C., Schouest, Blake, Maness, Nicholas J., Kim, Woong‐Ki

“…Zika virus (ZIKV) is a flavivirus that can cause neuropathogenesis in adults and fetal neurologic malformation following the infection of pregnant women. We…”
Get full text

Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis by Delery, Elizabeth, Bohannon, Diana G., Irons, Derek L., Allers, Carolina, Sugimoto, Chie, Cai, Yanhui, Merino, Kristen M., Amedee, Angela M., Veazey, Ronald S., MacLean, Andrew, Kuroda, Marcelo J., Kim, Woong-Ki

“…Despite combination antiretroviral therapies making HIV a chronic rather than terminal condition for many people, the prevalence of HIV-associated…”
Get full text