Immunomodulatory properties of Cumaside

Immunomodulatory properties of Cumaside

The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with or...

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Bibliographic Details
Published in:International immunopharmacology Vol. 6; no. 7; pp. 1070 - 1082
Main Authors: Aminin, D.L., Pinegin, B.V., Pichugina, L.V., Zaporozhets, T.S., Agafonova, I.G., Boguslavski, V.M., Silchenko, A.S., Avilov, S.A., Stonik, V.A.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-07-2006
Subjects:
Animals
Antigens, CD - immunology
Cucumaria - chemistry
Cucumaria japonica
Cucumariosides
Cumaside
Erythrocytes - drug effects
Glycosides
Hemolysis - drug effects
Holothurians
Holothurioidea
Humans
Hypersensitivity, Delayed - immunology
Immunity, Innate - drug effects
Immunity, Innate - immunology
Immunomodulatory activity
Leukocytes - drug effects
Leukocytes - immunology
Lysosomes - drug effects
Lysosomes - immunology
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Spleen - drug effects
Spleen - immunology
Staphylococcal Infections - prevention & control
Staphylococcus aureus - pathogenicity
Triterpenes - pharmacology
Yersinia pseudotuberculosis - pathogenicity
Yersinia pseudotuberculosis Infections - prevention & control
Cucumariosides
Cumaside
Immunomodulatory activity
Holothurians
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Summary:The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides due to the glycoside-cholesterol complex formation. The influence of Cumaside on mouse macrophages in low doses was accompanied by more then two-fold stimulation of lysosomal activity. This preparation was found to increase significantly the animal resistance against bacterial infections elicited by various pathogens. It stimulated phagocytosis, ROS formation, IL6 and TNF-α production in lymphocytes, increased the number of antibody producing cells and amplified the expression of several cell surface molecules (CD3, CD4, CD8) preliminary cultured with hydrocortisone. At the same time the preparation did not affect the delayed-type hypersensitivity, proliferative activity of lymphocytes, cytotoxic activity of NK-cells and cytokine IFNγ and IL12p70 release. The mechanism of Cumaside action is discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2006.01.017