Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience

In this single-center analysis, we evaluated the trends in 5185 hematopoietic cell transplantations performed between 1990 and 2022. The study group comprised 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) hematopoietic cell transplantations. In the multivariate analysis, there was an impro...

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Published in:	Cancers Vol. 15; no. 19; p. 4758
Main Authors:	Zubarovskaya, Ludmila Stepanovna, Moiseev, Ivan Sergeevich, Vladovskaya, Maria Dmidrievna, Mikhailova, Natalia Borisovna, Morozova, Elena Vladislavovna, Bykova, Tatyana Alexandrovna, Vlasova, Yulia Yurievna, Paina, Olesya Vladimirovna, Kazantsev, Ilya Viktorovich, Slesarchuk, Olga Alexandrovna, Smirnova, Anna Gennadyevna, Osipova, Anna Alekseevna, Stelmakh, Liliya Vladimirovna, Polushin, Alexey Yurievich, Goloshchapov, Oleg Valerievich, Bogomolny, Maxim Pavlovich, Estrina, Maria Arkadievna, Popova, Marina Olegovna, Kucher, Maxim Anatolievich, Volkova, Alisa Georgievna, Alyansky, Alexander Leonidovich, Pevtcov, Dmitrii Eduardovich, Ivanova, Natalia Evgenievna, Babenko, Elena Vitalievna, Mamaev, Nikolai Nikolaevich, Gindina, Tatiana Leonidovna, Vitrishchak, Alina Alexandrovna, Chukhlovin, Alexei Borisovich, Semenova, Elena Vladimirovna, Bondarenko, Sergei Nicolaevich, Kulagin, Alexander Dmitrievich, Afanasyev, Boris Vladimirovich
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 28-09-2023 MDPI
Subjects:	Acute lymphoblastic leukemia Acute myeloid leukemia Analysis Anemia Aplastic anemia Chronic lymphocytic leukemia Confidence intervals Developing countries Development and progression Disease Donors Ewings sarcoma Health aspects Hematopoietic stem cells LDCs Leukemia Lymphatic leukemia Lymphoma Lymphomas Morphology Mortality Multiple myeloma Multivariate analysis Non-Hodgkin's lymphoma Nuclear power plants Patients Research centers Solid tumors Stem cell transplantation Stem cells Survival analysis Transplantation Trends Tumors Russia
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Summary:	In this single-center analysis, we evaluated the trends in 5185 hematopoietic cell transplantations performed between 1990 and 2022. The study group comprised 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) hematopoietic cell transplantations. In the multivariate analysis, there was an improvement in event-free-survival (EFS) after autoHCT (HR 0.6, 95% CI 0.4–0.7, p < 0.0001) due to reduced cumulative incidence of relapse in the last five years (56% in 2010–2014 vs. 38% in 2015–2022). An improvement in EFS after alloHCT over time was observed (HR 0.33, 95% CI 0.23–0.48, p < 0.0001), which was due to reduced non-relapse mortality. No difference in cumulative relapse incidence was observed over the last decade for allografted patients. Survival after autoHCT improved in Hodgkin’s disease (HR 0.1, 95% CI 0.1–0.3), multiple myeloma (HR 0.4, 95% CI 0.2–0.7) and solid tumors (HR 0.2, 95% CI 0.2–0.4), while after alloHCT, improvement was observed in acute myeloid leukemia (HR 0.3, 95% CI 0.1–0.5), acute lymphoblastic leukemia (HR 0.2, 95% CI 0.1–0.5), Hodgkin’s disease (HR 0.1, 95% CI 0.0–0.4), non-Hodgkin’s lymphomas and chronic lymphocytic leukemia (HR 0.2, 95% CI 0.0–0.6), inborn diseases (HR 0.2, 95% CI 0.2–0.4) and acquired aplastic anemia with matched related donors and matched unrelated donors (HR 0.3, 95% CI 0.2–0.8).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2072-6694 2072-6694
DOI:	10.3390/cancers15194758