Search Results - "Bogdanová, Kateřina"
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Strong and Nonspecific Synergistic Antibacterial Efficiency of Antibiotics Combined with Silver Nanoparticles at Very Low Concentrations Showing No Cytotoxic Effect
Published in Molecules (Basel, Switzerland) (01-01-2016)“…The resistance of bacteria towards traditional antibiotics currently constitutes one of the most important health care issues with serious negative impacts in…”
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Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6‑Substituted 7‑(Het)aryl-7-deazapurine Ribonucleosides
Published in Journal of medicinal chemistry (13-02-2014)“…A series of 80 7-(het)aryl- and 7-ethynyl-7-deazapurine ribonucleosides bearing a methoxy, methylsulfanyl, methylamino, dimethylamino, methyl, or oxo group at…”
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3
Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins
Published in Scientific reports (17-05-2021)“…Lipophosphonoxins (LPPOs) are small modular synthetic antibacterial compounds that target the cytoplasmic membrane. First-generation LPPOs (LPPO I) exhibit an…”
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4
Silver nanoparticles strongly enhance and restore bactericidal activity of inactive antibiotics against multiresistant Enterobacteriaceae
Published in Colloids and surfaces, B, Biointerfaces (01-06-2016)“…[Display omitted] •Silver NPs restore bactericidal effect of antibiotics against resistant bacteria.•Double disk synergy test did not prove beta-lactamase…”
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LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials
Published in Journal of medicinal chemistry (28-07-2022)“…The alarming rise of bacterial antibiotic resistance requires the development of new compounds. Such compounds, lipophosphonoxins (LPPOs), were previously…”
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Detection of Prosthetic Joint Infection Based on Magnetically Assisted Surface Enhanced Raman Spectroscopy
Published in Analytical chemistry (Washington) (20-06-2017)“…Accurate and rapid diagnosis of prosthetic joint infection (PJI) is vital for rational and effective therapeutic management of this condition. Several…”
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Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents
Published in Journal of medicinal chemistry (27-07-2017)“…The increase in the number of bacterial strains resistant to known antibiotics is alarming. In this study we report the synthesis of novel compounds termed…”
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Antimicrobial and cytotoxic activity of (thio)alkyl hexopyranosides, nonionic glycolipid mimetics
Published in Carbohydrate research (01-02-2020)“…A series of 19 synthetic alkyl and thioalkyl glycosides derived from d-mannose, d-glucose and d-galactose and having C10–C16 aglycone were investigated for…”
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Clostridioides difficile and Vancomycin-Resistant Enterococci in COVID-19 Patients with Severe Pneumonia
Published in Life (Basel, Switzerland) (22-10-2021)“…Broad-spectrum antibiotics administered to patients with severe COVID-19 pneumonia pose a risk of infection caused by Clostridioides difficile. This risk is…”
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The application of antimicrobial photodynamic inactivation on methicillin-resistant S. aureus and ESBL-producing K. pneumoniae using porphyrin photosensitizer in combination with silver nanoparticles
Published in Photodiagnosis and photodynamic therapy (01-03-2021)“…•MRSA as well as ESBL-KP can be treated by activated porphyrin photosensitizer TMPyP and silver natoparticles.•Photodynamic inactivation with TMPyP followed by…”
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Ex Vivo Effect of Novel Lipophosphonoxins on Root Canal Biofilm Produced by Enterococcus faecalis: Pilot Study
Published in Life (Basel, Switzerland) (17-01-2022)“…(1) Background: The root canal system has complex anatomical and histological features that make it impossible to completely remove all bacteria by mechanical…”
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The Short-Term Antibacterial Activity of Three Selected Endodontic Sealers against Enterococcus faecalis Bacterial Culture
Published in Life (Basel, Switzerland) (21-01-2022)“…(1) Background: Microorganisms originating from the microflora of the oral cavity are the main cause of the inflammatory diseases of the dental pulp and…”
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Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
Published in European journal of medicinal chemistry reports (01-12-2024)“…Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often…”
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Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement
Published in ACS omega (25-02-2020)“…Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period…”
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Caffeine–hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells
Published in Bioorganic chemistry (01-06-2015)“…[Display omitted] •Caffeine–hydrazones were prepared in three-step synthesis.•Anticancer activity tested on the 7 cancer and 2 healthy cell lines.•High…”
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Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties
Published in Journal of medicinal chemistry (24-11-2011)“…Novel compounds termed lipophosphonoxins were prepared using a simple and efficient synthetic approach. The general structure of lipophosphonoxins consists of…”
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Dimeric cyanobacterial cyclopent-4-ene-1,3-dione as selective inhibitor of Gram-positive bacteria growth: Bio-production approach and preparative isolation by HPCCC
Published in Algal research (Amsterdam) (01-09-2016)“…The need for new antimicrobial agents is greater than ever because of the emergence of multidrug resistance in common pathogens and incidence of new…”
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Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins
Published in PloS one (30-12-2015)“…The advantages offered by established antibiotics in the treatment of infectious diseases are endangered due to the increase in the number of…”
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Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity
Published in European journal of medicinal chemistry (01-09-2010)“…A series of uridine analogues modified at the 5-position with the 5-[alkoxy-(4-nitrophenyl)-methyl] moiety was synthesized. Nucleosides were formed as a…”
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Direct identification of bacteria in blood cultures by MALDI-TOF MS
Published in Klinicka mikrobiologie a infekcni lekarstvi (01-06-2020)“…Early and causal administration of antibiotics in patients with a positive blood culture is an essential prerequisite for successful treatment of infection…”
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