Search Results - "Bogdan, Andrew R."

Synthesis of 5-Iodo-1,2,3-triazole-Containing Macrocycles Using Copper Flow Reactor Technology by Bogdan, Andrew R, James, Keith

“…A new macrocyclization strategy to synthesize 12- to 31-membered 5-iodo-1,2,3-triazole-containing macrocycles is described. The macrocycles have been generated…”
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Efficient Access to New Chemical Space Through Flow-Construction of Druglike Macrocycles Through Copper-Surface-Catalyzed Azide-Alkyne Cycloaddition Reactions by Bogdan, Andrew R., James, Keith

“…A series of 12‐ to 22‐membered macrocycles, with druglike functionality and properties, have been generated by using a simple and efficient copper‐catalyzed…”
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The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles by Bogdan, Andrew R., Sach, Neal W.

“…A library of 1,4‐disubstituted 1,2,3‐triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium…”
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Greener Approaches to Organic Synthesis Using Microreactor Technology by Mason, Brian P, Price, Kristin E, Steinbacher, Jeremy L, Bogdan, Andrew R, McQuade, D. Tyler

“…A review of the application of microreactor technology on organic synthesis is presented. Microreactors can provide increased safety and a potential for…”
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The Continuous-Flow Synthesis of Ibuprofen by Bogdan, Andrew R., Poe, Sarah L., Kubis, Daniel C., Broadwater, Steven J., McQuade, D. Tyler

“…Let relief flow forth! A three‐step, continuous‐flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which…”
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Strained Cyclophane Macrocycles: Impact of Progressive Ring Size Reduction on Synthesis and Structure by Bogdan, Andrew R, Jerome, Steven V, Houk, K. N, James, Keith

“…The synthesis, X-ray crystal structures, and calculated strain energies are reported for a homologous series of 11- to 14-membered drug-like cyclophane…”
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Comparison of diffusion coefficients for matched pairs of macrocyclic and linear molecules over a drug-like molecular weight range by Bogdan, Andrew R, Davies, Nichola L, James, Keith

“…The diffusion coefficients of a series of closely matched pairs of macrocyclic and linear molecules have been compared using NMR spectroscopy. The macrocyclic…”
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Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry by Bogdan, Andrew R, Dombrowski, Amanda W

“…The field of flow chemistry has garnered considerable attention over the past 2 decades. This Perspective highlights many recent advances in the field of flow…”
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Improving Solid-Supported Catalyst Productivity by Using Simplified Packed-Bed Microreactors by Bogdan, Andrew R., Mason, Brian P., Sylvester, Kevin T., McQuade, D. Tyler

“…Going with the flow: Packed‐bed microreactors are formed from polymeric tubing and a resin‐supported catalyst. By using supported catalysts in flow systems,…”
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A General Approach to Creating Soluble Catalytic Polymers Heterogenized in Microcapsules by Mason, Brian P, Bogdan, Andrew R, Goswami, Anandarup, McQuade, D. Tyler

“…A general method for preparing site-isolated polymeric catalysts is presented. Linear chloromethyl and azide polymers have been sequestered within polyurea…”
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Pd‐PEPPSI‐IPent‐SiO2: A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow by Price, Gregory A., Hassan, Abbas, Chandrasoma, Nalin, Bogdan, Andrew R., Djuric, Stevan W., Organ, Michael G.

“…A silica‐supported precatalyst, Pd‐PEPPSI‐IPent‐SiO2, has been prepared and evaluated for its proficiency in the Negishi cross‐coupling of hindered and…”
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Evaluation of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Cysteinome Reactivity by Rabalski, Adam J, Bogdan, Andrew R, Baranczak, Aleksandra

“…Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents…”
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Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)–C(sp3) Cross-Coupling Methods by Library Synthesis by Dombrowski, Amanda W, Gesmundo, Nathan J, Aguirre, Ana L, Sarris, Katerina A, Young, Jonathon M, Bogdan, Andrew R, Martin, M. Cynthia, Gedeon, Shasline, Wang, Ying

“…Despite recent advances in the field of C­(sp2)–C­(sp3) cross-couplings and the accompanying increase in publications, it can be hard to determine which method…”
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Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor by Tsoung, Jennifer, Bogdan, Andrew R, Kantor, Stanislaw, Wang, Ying, Charaschanya, Manwika, Djuric, Stevan W

“…Fused pyrimidinone and quinolone derivatives that are of potential interest to pharmaceutical research were synthesized within minutes in up to 96% yield in an…”
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Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor by Charaschanya, Manwika, Bogdan, Andrew R., Wang, Ying, Djuric, Stevan W.

“…[Display omitted] We report herein a high-temperature and high-pressure continuous-flow protocol to carry out nucleophilic aromatic substitution (SNAr) of…”
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High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences by Bogdan, Andrew R, Charaschanya, Manwika, Dombrowski, Amanda W, Wang, Ying, Djuric, Stevan W

“…A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected…”
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A New Flow Methodology for the Expedient Synthesis of Drug-Like 3-Aminoindolizines by Lange, Paul P., Bogdan, Andrew R., James, Keith

“…A flow‐based synthesis of diversely functionalized indolizines and their aza‐analogues is described. These drug‐like heterocycles were generated via a tandem…”
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Pd-PEPPSI-IPent-SiO 2 : A Supported Catalyst for Challenging Negishi Coupling Reactions in Flow by Price, Gregory A, Hassan, Abbas, Chandrasoma, Nalin, Bogdan, Andrew R, Djuric, Stevan W, Organ, Michael G

“…A silica-supported precatalyst, Pd-PEPPSI-IPent-SiO , has been prepared and evaluated for its proficiency in the Negishi cross-coupling of hindered and…”
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Use of Bifunctional Ureas to Increase the Rate of Proline-Catalyzed α-Aminoxylations by Poe, Sarah L, Bogdan, Andrew R, Mason, Brian P, Steinbacher, Jeremy L, Opalka, Suzanne M, McQuade, D. Tyler

“…The rate of the proline-catalyzed α-aminoxylation of aldehydes is significantly increased in the presence of a bifunctional urea. Structure−activity…”
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Microencapsulated Linear Polymers:  “Soluble” Heterogeneous Catalysts by Price, Kristin E, Mason, Brian P, Bogdan, Andrew R, Broadwater, Steven J, Steinbacher, Jeremy L, McQuade, D. Tyler

“…A new strategy for supporting catalysts based on the microencapsulation of linear polymers is presented. In this paper, we present a DMAP capsule that is…”
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