Search Results - "Bogaerdt, Antoon"

Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice by Mulder, Inge A., Li, Mei, Vries, Tessa, Qin, Tao, Yanagisawa, Takeshi, Sugimoto, Kazutaka, Bogaerdt, Antoon, Danser, A. H. Jan, Wermer, Marieke J. H., Maagdenberg, Arn M. J. M., MaassenVanDenBrink, Antoinette, Ferrari, Michel D., Ayata, Cenk

“…Objective Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging treatments for migraine. CGRP‐mediated vasodilation is, however, a critical…”
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Pharmacology of erenumab in human isolated coronary and meningeal arteries: Additional effect of gepants on top of a maximum effect of erenumab by Vries, Tessa, Rubio‐Beltrán, Eloísa, Bogaerdt, Antoon, Dammers, Ruben, Danser, A. H. Jan, Snellman, Josefin, Bussiere, Jeanine, MaassenVanDenBrink, Antoinette

“…Background and Purpose Multiple drugs targeting the calcitonin gene‐related peptide (CGRP) receptor have been developed for migraine treatment. Here, the…”
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Intracellular pathways of calcitonin gene‐related peptide‐induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP by Vries, Tessa, Labruijere, Sieneke, Rivera‐Mancilla, Eduardo, Garrelds, Ingrid M., Vries, René, Schutter, Dennis, Bogaerdt, Antoon, Poyner, David R., Ladds, Graham, Danser, A. H. Jan, MaassenVanDenBrink, Antoinette

“…Background and Purpose Calcitonin gene‐related peptide (CGRP) is a potent vasodilator. While its signalling is assumed to be mediated via increases in cAMP,…”
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Characterization of binding, functional activity, and contractile responses of the selective 5‐HT1F receptor agonist lasmiditan by Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B., Johnson, Kirk W., Kovalchin, Joseph, Villalón, Carlos M., MaassenVanDenBrink, Antoinette

“…Background and Purpose Triptans are 5‐HT1B/1D receptor agonists (that also display 5‐HT1F receptor affinity) with antimigraine action, contraindicated in…”
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High proportion of genetic cases in patients with advanced cardiomyopathy including a novel homozygous Plakophilin 2-gene mutation by Klauke, Baerbel, Gaertner-Rommel, Anna, Schulz, Uwe, Kassner, Astrid, Zu Knyphausen, Edzard, Laser, Thorsten, Kececioglu, Deniz, Paluszkiewicz, Lech, Blanz, Ute, Sandica, Eugen, van den Bogaerdt, Antoon J, van Tintelen, J Peter, Gummert, Jan, Milting, Hendrik

“…Cardiomyopathies might lead to end-stage heart disease with the requirement of drastic treatments like bridging up to transplant or heart transplantation. A…”
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Endothelin-1- and acetylcholine-mediated effects in human and rat vessels: impact of perivascular adipose tissue, diabetes, angiotensin II, and chemerin by Cruz-López, Edwyn O, Tan, Lunbo, Stolk, Daniël G, van den Bogaerdt, Antoon J, Verdonk, Koen, Danser, A H Jan

“…To study the role of perivascular adipose tissue (PVAT) in the reactivity of rat and human vessels. Iliac and mesenteric arteries were obtained from…”
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Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia by Tan, Lunbo, Kluivers, Ans C M, Cruz-López, Edwyn O, Broekhuizen, Michelle, Chen, Zhongli, Neuman, Rugina I, Schoenmakers, Sam, Ruijgrok, Liesbeth, van de Velde, Daan, de Winter, Brenda C M, van den Bogaerdt, Antoon J, Lu, Xifeng, Danser, A H Jan, Verdonk, Koen

“…Chemerin, an inflammatory adipokine, is upregulated in preeclampsia, and its placental overexpression results in preeclampsia-like symptoms in mice. Statins…”
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Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves by van Geemen, Daphne, Soares, Ana L F, Oomen, Pim J A, Driessen-Mol, Anita, Janssen-van den Broek, Marloes W J T, van den Bogaerdt, Antoon J, Bogers, Ad J J C, Goumans, Marie-José T H, Baaijens, Frank P T, Bouten, Carlijn V C

“…There is limited information about age-specific structural and functional properties of human heart valves, while this information is key to the development…”
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Prospective evaluation of clinical outcomes between pre‐cut corneal grafts prepared using a manual or automated technique: with one‐year follow‐up by Muijzer, Marc B., van Luijk, Chantal M., van den Bogaerdt, Antoon J., Kruit, Piet J., Groeneveld‐van Beek, Esther, Melles, Gerrit R.J., Wisse, Robert P.L.

“…Purpose Posterior lamellar corneal surgery is considered the standard of care for irreversible endothelial cell dysfunction. Pre‐cut grafts can be prepared…”
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Qualitative evaluation of coronary atherosclerosis in a large cohort of young and middle-aged Dutch tissue donors implies that coronary thrombo-embolic manifestations are stochastic by Lindeman, Jan H, Hulsbos, Luuk, van den Bogaerdt, Antoon J, Geerts, Marlieke, van Gool, Alain J, Hamming, Jaap F, van Dijk, Rogier A, Schaapherder, Alexander F

“…With the intention to gain support for the hypothesis that incident ischemic complications of atherosclerotic disease involve a stochastic aspect, we performed…”
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Compound 21 Induces Vasorelaxation via an Endothelium- and Angiotensin II Type 2 Receptor-Independent Mechanism by Verdonk, Koen, Durik, Matej, Abd-Alla, Nalina, Batenburg, Wendy W, van den Bogaerdt, Antoon J, van Veghel, Richard, Roks, Anton J.M, Danser, A.H Jan, van Esch, Joep H.M

“…Angiotensin II type 2 (AT2) receptor stimulation has been linked to vasodilation. Yet, AT2 receptor-independent hypertension and hypotension (or no effect on…”
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Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis by Meershoek, Armelle, van Dijk, Rogier A, Verhage, Sander, Hamming, Jaap F, van den Bogaerdt, Antoon J, Bogers, Ad J.J.C, Schaapherder, Alexander F, Lindeman, Jan H

“…Abstract Background/objectives Carotid intimal media thickness (IMT) and coronary calcium scores (CCS) are thought to reflect atherosclerotic burden. The…”
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Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease by Wu, Haiyan, Roks, Anton J M, Leijten, Frank P J, Garrelds, Ingrid M, Musterd-Bhaggoe, Usha M, van den Bogaerdt, Antoon J, de Maat, Moniek P M, Simoons, Maarten L, Danser, A H Jan, Oeseburg, Hisko

“…The efficacy of the ACE (angiotensin-converting enzyme) inhibitor perindopril in coronary artery disease [EUROPA (European trial on reduction of cardiac events…”
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Pharmacological characterization of VIP and PACAP receptors in the human meningeal and coronary artery by Chan, Kayi Y, Baun, Michael, de Vries, René, van den Bogaerdt, Antoon J, Dirven, Clemens M F, Danser, Alexander H J, Jansen-Olesen, Inger, Olesen, Jes, Villalón, Carlos M, MaassenVanDenBrink, Antoinette, Gupta, Saurabh

“…We pharmacologically characterized pituitary adenylate cyclase-activating polypeptides (PACAPs), vasoactive intestinal peptide (VIP) and the VPAC(1), VPAC(2)…”
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Long-lasting physiological antagonism of calcitonin gene-related peptide towards endothelin-1 in rat mesenteric arteries and human coronary arteries by Labruijere, Sieneke, Compeer, Matthijs G., van den Bogaerdt, Antoon J., van den Brink, Antoinette Maassen, De Mey, Jo G.R., Danser, A.H. Jan, Batenburg, Wendy W.

“…Endothelin-1 causes long-lasting contraction via endothelin type A receptor (ETAR) in isolated rat mesenteric arteries (RMA) that cannot be readily terminated…”
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Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves by Dekker, Sylvia, van Geemen, Daphne, van den Bogaerdt, Antoon J, Driessen-Mol, Anita, Aikawa, Elena, Smits, Anthal I P M

“…The creation of living heart valve replacements via tissue engineering is actively being pursued by many research groups. Numerous strategies have been…”
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Development of an in vitro burn wound model by Coolen, Neeltje A., Vlig, Marcel, Van Den Bogaerdt, Antoon J., Middelkoop, Esther, Ulrich, Magda M. W.

“…ABSTRACT Healing of a deeper burn wound is a complex process that often leads to scar formation. Skin wound model systems are important for the development of…”
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Dihydroergotamine and sumatriptan in isolated human coronary artery, middle meningeal artery and saphenous vein by Labruijere, Sieneke, Chan, Kayi Y, de Vries, René, van den Bogaerdt, Antoon J, Dirven, Clemens M, Danser, Ah Jan, Kori, Shashidhar H, MaassenVanDenBrink, Antoinette

“…Dihydroergotamine (DHE) and sumatriptan are contraindicated in patients with cardiovascular disease because of their vasoconstricting properties, which have…”
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Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy by Labastida-Ramírez, Alejandro, Rubio-Beltrán, Eloísa, Haanes, Kristian A., de Vries, René, Dammers, Ruben, Bogers, A. J. J. C., van den Bogaerdt, Antoon, Daugherty, Bruce L., Danser, Alexander H. J., Villalón, Carlos M., MaassenVanDenBrink, Antoinette

“…Background Racemic isometheptene [( RS )-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers,…”
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Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon by van der Slot, Annemarie J, Zuurmond, Anne-Marie, van den Bogaerdt, Antoon J, Ulrich, Magda M.W, Middelkoop, Esther, Boers, Willem, Karel Ronday, H, DeGroot, Jeroen, Huizinga, Tom W.J, Bank, Ruud A

“…Fibrosis is characterized by an excessive accumulation of collagen which contains increased levels of pyridinoline cross-links. The occurrence of pyridinolines…”
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