Search Results - "Boffa, L C"

Effects in live cells of a c- myc anti-gene PNA linked to a nuclear localization signal by Boffa, Lidia C, Cutrona, Giovanna, Carpaneto, Elisabetta M, Ulivi, Massimo, Roncella, Silvio, Landt, Olfert, Ferrarini, Manlio

“…Peptide nucleic acids (PNA) are synthetic homologs of nucleic acids in which the phosphate-sugar polynucleotide backbone is replaced by a flexible polyamide…”
Get full text

Inhibition of Burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated c-myc by Boffa, L C, Cutrona, G, Cilli, M, Matis, S, Damonte, G, Mariani, M R, Millo, E, Moroni, M, Roncella, S, Fedeli, F, Ferrarini, M

“…In Burkitt's lymphoma (BL) cells due to a t(8;14) chromosomal translocation c-myc is often placed in proximity to the Emu enhancer of the Ig locus and…”
Get full text

CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALL by CUTRONA, G, TASSO, P, FRASCELLA, E, BOFFA, L. C, BASSO, G, PISTOIA, V, FERRARINI, M, DONO, M, RONCELLA, S, ULIVI, M, CARPANETO, E. M, FONTANA, V, COMIS, M, MORABITO, F, SPINELLI, M

“…CD10 constitutes a favourable prognostic marker for childhood acute lymphoblastic leukaemia. Since correlations between CD10, cell cycle and apoptotic…”
Get full text

Dihydrotestosterone as a selective cellular/nuclear localization vector for anti-gene peptide nucleic acid in prostatic carcinoma cells by BOFFA, L. C, SCARFI, S, MARIANI, M. R, DAMONTE, G, ALLFREY, V. G, BENATTI, U, MORRIS, P. L

“…Peptide nucleic acids (PNAs) are synthetic structural analogues of DNA and RNA that, if allowed to enter the cell, bind to the complementary polynucleotide…”
Get full text

Lack of mutagenicity and clastogenicity of PNAEμ-NLS targeted to a regulatory sequence of the translocated c- myc oncogene in Burkitt's lymphoma by Boffa, L.C., Menichini, P., Bolognesi, C., Cutrona, G., Roncella, S., Damonte, G.L., Millo, E., Mariani, M.R., Matis, S., Russo, D., Ciliutti, P., Ferrarini, M.

“…Peptide nucleic acids (PNAs) are synthetic homolog of nucleic acids in which the phosphate-sugar polynucleotide backbone is replaced by a flexible polyamide…”
Get full text

Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats by BOFFA, L. C, LUPTON, J. R, MARIANI, M. R, CEPPI, M, NEWMARK, H. L, SCALMATI, A, LIPKIN, M

“…The effect of increasing amounts of wheat bran (0, 5, 10, 20%) in AIN-76 semisynthetic diet on colonic luminal short chain fatty acids, epithelial cell histone…”
Get full text

Isolation of Active Genes Containing CAG Repeats by DNA Strand Invasion by a Peptide Nucleic Acid by Boffa, Lidia C., Carpaneto, Elisabetta M., Allfrey, Vincent G.

“…An amplification of tandem CAG trinucleotide sequences in DNA due to errors in DNA replication is involved in at least four hereditary neurodegenerative…”
Get full text

PNAE[mu] can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease by Matis, S, Mariani, M R, Cutrona, G, Cilli, M, Piccardi, F, Daga, A, Damonte, G, Millo, E, Moroni, M, Roncella, S, Fedeli, F, Boffa, L C, Ferrarini, M

“…In human Burkitt's Lymphoma (BL) BRG cells, a t(8;14) translocation, placing c-myc near the Emu enhancer of the H chain locus, causes tumor expansion. Earlier,…”
Get full text

PNAEμ can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease by Matis, S, Mariani, M R, Cutrona, G, Cilli, M, Piccardi, F, Daga, A, Damonte, G, Millo, E, Moroni, M, Roncella, S, Fedeli, F, Boffa, L C, Ferrarini, M

“…In human Burkitt's Lymphoma (BL) BRG cells, a t(8;14) translocation, placing c-myc near the Eμ enhancer of the H chain locus, causes tumor expansion. Earlier,…”
Get full text

Selective hypermethylation of transcribed nucleosomal DNA by sodium butyrate by Boffa, L C, Mariani, M R, Parker, M I

“…Previous studies have shown that treatment of cultured fibroblasts with millimolar concentrations of sodium butyrate results in increased methylation of…”
Get more information

Recovery of transcriptionally active chromatin restriction fragments by binding to organomercurial-agarose magnetic beads. A rapid and sensitive method for monitoring changes in higher order chromatin structure during gene activation and repression by CHEN-CLELAND, T. A, BOFFA, L. C, CARPANETO, E. M, MARIANI, M. R, VALENTIN, E, MENDEZ, E, ALLFREY, V. G

“…The unfolding of nucleosomes along transcriptionally active DNA sequences uncovers previously shielded cysteinyl-thiol groups of histone H3 molecules located…”
Get full text

Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions by Boffa, L C, Gruss, R J, Allfrey, V G

“…In addition to its known effect in suppressing the deacetylation of the nucleosomal core histones, sodium butyrate in the concentration range 0.5 to 15 mM…”
Get full text

Contrasting effects of PNA invasion of the chimeric DMMYC gene on transcription of its myc and PVT domains by Boffa, L C, Carpaneto, E M, Mariani, M R, Louissaint, M, Allfrey, V G

“…A peptide nucleic acid (PNA) complementary to a unique DNA sequence in the second exon of the human myc proto-oncogene was tested for its effects on…”
Get more information

Characterization of the non-histone nuclear proteins associated with rapidly labeled heterogeneous nuclear RNA by Karn, J, Vidali, G, Boffa, L C, Allfrey, V G

Get full text

Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers by Alagón, Alejandro, Stock, Roberto P, Olvera, Alejandro, Sánchez, Ricardo, Saralegui, Andrés, Scarfì, Sonia, Sanchez-Lopez, Rosana, Ramos, Marco A, Boffa, Lidia C, Benatti, Umberto

“…Peptide nucleic acids (PNAs) may be a potent tool for gene function studies in medically important parasitic organisms, especially those that have not before…”
Get full text

Cell cycle-dependent changes in conformation and composition of nucleosomes containing human histone gene sequences by STERNER, R, BOFFA, L. C, CHEN, T. A, ALLFREY, V. G

“…Unfolding of the nucleosomes in transcriptionally active chromatin uncovers the sulfhydryl groups of histone H3 and permits the selective recovery of the…”
Get full text

Methylating agents: their target amino acids in nuclear proteins by Boffa, L C, Bolognesi, C

“…We have tried to establish a correlation between the carcinogenic potency of four methylating compounds and their specific target sites in chromatin. We have…”
Get more information

Target tissue DNA damage in inbred mouse strains with different susceptibility to the colon carcinogen 1,2-dimethylhydrazine by Bolognesi, C, Mariani, M R, Boffa, L C

“…We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific…”
Get more information

Comparative structural analysis of high mobility group proteins from a variety of sources : Evidence for a high mobility group protein unique to avian erythrocyte nuclei by Sterner, R, Boffa, L.C, Vidali, G

Get full text

Correlation between butyrate-induced histone hyperacetylation turn-over and c-myc expression by Mariani, Maria Rita, Carpaneto, Elisabetta M., Ulivi, Massimo, Allfrey, Vincent G., Boffa, Lidia C.

“…Transcriptionally active chromatin has an high level of histone acetylation, a post-transcriptional modification known to alter nucleosomal conformation…”
Get full text