Search Results - "Boffa, Iolanda"

Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma by Orlando, Domenico, Miele, Evelina, De Angelis, Biagio, Guercio, Marika, Boffa, Iolanda, Sinibaldi, Matilde, Po, Agnese, Caruana, Ignazio, Abballe, Luana, Carai, Andrea, Caruso, Simona, Camera, Antonio, Moseley, Annemarie, Hagedoorn, Renate S, Heemskerk, Mirjam H M, Giangaspero, Felice, Mastronuzzi, Angela, Ferretti, Elisabetta, Locatelli, Franco, Quintarelli, Concetta

“…Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity. Identification of new therapeutic targets would be instrumental in…”
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Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma by Quintarelli, Concetta, Orlando, Domenico, Boffa, Iolanda, Guercio, Marika, Polito, Vinicia Assunta, Petretto, Andrea, Lavarello, Chiara, Sinibaldi, Matilde, Weber, Gerrit, Del Bufalo, Francesca, Giorda, Ezio, Scarsella, Marco, Petrini, Stefania, Pagliara, Daria, Locatelli, Franco, De Angelis, Biagio, Caruana, Ignazio

“…Chimeric antigen receptor (CAR) T-cell therapy has been shown to be dramatically effective in the treatment of B-cell malignancies. However, there are still…”
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CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T-cells by Guercio, Marika, Orlando, Domenico, Di Cecca, Stefano, Sinibaldi, Matilde, Boffa, Iolanda, Caruso, Simona, Abbaszadeh, Zeinab, Camera, Antonio, Cembrola, Biancamaria, Bovetti, Katia, Manni, Simona, Caruana, Ignazio, Ciccone, Roselia, Del Bufalo, Francesca, Merli, Pietro, Vinti, Luciana, Girardi, Katia, Ruggeri, Annalisa, De Stefanis, Cristiano, Pezzullo, Marco, Giorda, Ezio, Scarsella, Marco, De Vito, Rita, Barresi, Sabina, Ciolfi, Andrea, Tartaglia, Marco, Moretta, Lorenzo, Locatelli, Franco, Quintarelli, Concetta, De Angelis, Biagio

“…The prognosis of many patients with chemotherapy-refractory or multiply relapsed CD30+ non-Hodgkin Lymphoma (NHL) or Hodgkin lymphoma (HL) still remains poor,…”
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Liver‐directed gene therapy for ornithine aminotransferase deficiency by Boffa, Iolanda, Polishchuk, Elena, De Stefano, Lucia, Dell'Aquila, Fabio, Nusco, Edoardo, Marrocco, Elena, Audano, Matteo, Pedretti, Silvia, Caterino, Marianna, Bellezza, Ilaria, Ruoppolo, Margherita, Mitro, Nico, Cellini, Barbara, Auricchio, Alberto, Brunetti‐Pierri, Nicola

“…Gyrate atrophy of choroid and retina (GACR) is a chorioretinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase…”
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Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies by Guercio, Marika, Manni, Simona, Boffa, Iolanda, Caruso, Simona, Di Cecca, Stefano, Sinibaldi, Matilde, Abbaszadeh, Zeinab, Camera, Antonio, Ciccone, Roselia, Polito, Vinicia Assunta, Ferrandino, Francesca, Reddel, Sofia, Catanoso, Maria Luigia, Bocceri, Emilia, Del Bufalo, Francesca, Algeri, Mattia, De Angelis, Biagio, Quintarelli, Concetta, Locatelli, Franco

“…T cells engineered with chimeric antigen receptor (CAR-T cells) are an effective treatment in patients with relapsed/refractory B-cell precursor acute…”
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O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis by Soria, Leandro R., Makris, Georgios, D’Alessio, Alfonso M., De Angelis, Angela, Boffa, Iolanda, Pravata, Veronica M., Rüfenacht, Véronique, Attanasio, Sergio, Nusco, Edoardo, Arena, Paola, Ferenbach, Andrew T., Paris, Debora, Cuomo, Paola, Motta, Andrea, Nitzahn, Matthew, Lipshutz, Gerald S., Martínez-Pizarro, Ainhoa, Richard, Eva, Desviat, Lourdes R., Häberle, Johannes, van Aalten, Daan M. F., Brunetti-Pierri, Nicola

“…Life-threatening hyperammonemia occurs in both inherited and acquired liver diseases affecting ureagenesis, the main pathway for detoxification of neurotoxic…”
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Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts by Quintarelli, Concetta, Guercio, Marika, Manni, Simona, Boffa, Iolanda, Sinibaldi, Matilde, Di Cecca, Stefano, Caruso, Simona, Abbaszadeh, Zeinab, Camera, Antonio, Cembrola, Biancamaria, Ciccone, Roselia, Orfao, Alberto, Martin-Martin, Lourdes, Gutierrez-Herrero, Sara, Herrero-Garcia, Maria, Cazzaniga, Gianni, Nunes, Vittorio, Songia, Simona, Marcatili, Paolo, Marin, Frederikke I, Ruella, Marco, Bertaina, Valentina, Vinti, Luciana, Del Bufalo, Francesca, Algeri, Mattia, Merli, Pietro, De Angelis, Biagio, Locatelli, Franco

“…Chimeric antigen receptor T-cells (CAR T-cells) for the treatment of relapsing/refractory B-cell precursor acute lymphoblastic leukemia have led to exciting…”
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Vision on gyrate atrophy: why treat the liver? by Boffa, Iolanda, Brunetti-Pierri, Nicola

“…Gyrate Atrophy of the Choroid and Retina (GACR) currently lacks any effective treatment and a highly restricted, yet cumbersome, low-arginine diet is the only…”
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Liver gene transfer for metabolite detoxification in inherited metabolic diseases by D'Alessio, Alfonso M., Boffa, Iolanda, De Stefano, Lucia, Soria, Leandro R., Brunetti‐Pierri, Nicola

“…Inherited metabolic disorders (IMDs) are a growing group of genetic diseases caused by defects in enzymes that mediate cellular metabolism, often resulting in…”
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Natural compounds for pediatric cancer treatment by Ferrucci, Veronica, Boffa, Iolanda, De Masi, Gina, Zollo, Massimo

“…There is a tremendous need in clinics to impair cancer progression through noninvasive therapeutic approaches. The use of natural compounds to achieve this is…”
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Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition by Ferrucci, Veronica, de Antonellis, Pasqualino, Pennino, Francesco Paolo, Asadzadeh, Fatemeh, Virgilio, Antonella, Montanaro, Donatella, Galeone, Aldo, Boffa, Iolanda, Pisano, Ida, Scognamiglio, Iolanda, Navas, Luigi, Diana, Donatella, Pedone, Emilia, Gargiulo, Sara, Gramanzini, Matteo, Brunetti, Arturo, Danielson, Laura, Carotenuto, Marianeve, Liguori, Lucia, Verrico, Antonio, Quaglietta, Lucia, Errico, Maria Elena, Del Monaco, Valentina, D'Argenio, Valeria, Tirone, Felice, Mastronuzzi, Angela, Donofrio, Vittoria, Giangaspero, Felice, Picard, Daniel, Remke, Marc, Garzia, Livia, Daniels, Craig, Delattre, Olivier, Swartling, Fredrik J, Weiss, William A, Salvatore, Francesco, Fattorusso, Roberto, Chesler, Louis, Taylor, Michael D, Cinalli, Giuseppe, Zollo, Massimo

“…The molecular events underlying dissemination of group 3 medulloblastoma remain elusive. Ferrucci et al. show that PRUNE1 overexpression enhances the canonical…”
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Patient-Derived Chimeric Antigen Receptor T-Cell Production Based on a Gammaretroviral Vector Platform Is Not Associated with Generation of CAR+ Leukemia Blasts by Quintarelli, Concetta, Boffa, Iolanda, Sinibaldi, Matilde, Orlando, Domenico, Guercio, Marika, Di Cecca, Stefano, Caruso, Simona, Pitisci, Angela, Bertaina, Valentina, Del Bufalo, Francesca, Merli, Pietro, Algeri, Mattia, Galaverna, Federica, Vinti, Luciana, Li Pira, Giuseppina, De Angelis, Biagio, Locatelli, Franco

“…In view of the exciting results reported in patients with CD19+ malignancies given CAR T cells, it is expected that a continuously growing number of patients…”
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CD19 Redirected CAR NK Cells Are Equally Effective but Less Toxic Than CAR T Cells by Quintarelli, Concetta, Sivori, Simona, Caruso, Simona, Carlomagno, Simona, Boffa, Iolanda, Orlando, Domenico, Guercio, Marika, Cembrola, Biancamaria, Pitisci, Angela, Di Cecca, Stefano, Li Pira, Giuseppina, Vinti, Luciana, De Angelis, Biagio, Moretta, Lorenzo, Locatelli, Franco

“…Based on the clinical success observed in acute lymphoblastic leukemia (ALL) with chimeric antigen receptor engineered T (CAR T), we hypothesized that…”
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A New Promising Third Generation CAR-CD30 T-Cell Therapy for CD30+ Lymphoma by De Angelis, Biagio, Guercio, Marika, Orlando, Domenico, Di Cecca, Stefano, Sinibaldi, Matilde, Boffa, Iolanda, Caruso, Simona, Abbaszadeh, Zeinab, Camera, Antonio, Biancamaria, Cembrola, Bovetti, Katia, Caruana, Ignazio, Del Bufalo, Francesca, Merli, Pietro, Vinti, Luciana, Girardi, Katia, Ruggeri, Annalisa, De Vito, Rita, Quintarelli, Concetta, Locatelli, Franco

“…Prognosis of a significant proportion of patients with chemotherapy-refractory or multiply-relapsed CD30+ Non-Hodgkin's Lymphoma (NHL) or Hodgkin lymphoma (HL)…”
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Early Targets of miR-34a in Neuroblastoma by De Antonellis, Pasqualino, Carotenuto, Marianeve, Vandenbussche, Jonathan, De Vita, Gennaro, Ferrucci, Veronica, Medaglia, Chiara, Boffa, Iolanda, Galiero, Alessandra, Di Somma, Sarah, Magliulo, Daniela, Aiese, Nadia, Alonzi, Alessandro, Spano, Daniela, Liguori, Lucia, Chiarolla, Cristina, Verrico, Antonio, Schulte, Johannes H., Mestdagh, Pieter, Vandesompele, Jo, Gevaert, Kris, Zollo, Massimo

“…Several genes encoding for proteins involved in proliferation, invasion, and apoptosis are known to be direct miR-34a targets. Here, we used proteomics to…”
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A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction by Carotenuto, Marianeve, de Antonellis, Pasqualino, Chiarolla, Cristina Maria, Attanasio, Carmela, Damiani, Valentina, Boffa, Iolanda, Aiese, Nadia, Pedone, Emilia, Accordi, Benedetta, Basso, Giuseppe, Navas, Luigi, Imbimbo, Ciro, Zollo, Massimo

“…Nm23-H1 is a metastasis suppressor gene whose overexpression is associated with both reduced cell motility in various cancers and increased metastatic…”
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Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibitio by Ferrucci, Veronica, de Antonellis, Pasqualino, Pennino, Francesco Paolo, Asadzadeh, Fatemeh, Virgilio, Antonella, Montanaro, Donatella, Galeone, Aldo, Boffa, Iolanda, Pisano, Ida, Scognamiglio, Iolanda, Navas, Luigi, Diana, Donatella, Pedone, Emilia, Gargiulo, Sara, Gramanzini, Matteo, Brunetti, Arturo, Danielson, Laura, Carotenuto, Marianeve, Liguori, Lucia, Verrico, Antonio, Quaglietta, Lucia, Errico, Maria Elena, Del Monaco, Valentina, D'Argenio, Valeria, Tirone, Felice, Mastronuzzi, Angela, Donofrio, Vittoria, Giangaspero, Felice, Picard, Daniel, Remke, Marc, Garzia, Livia, Daniels, Craig, Delattre, Olivier, Johansson, Fredrik K., Weiss, William A., Salvatore, Francesco, Fattorusso, Roberto, Chesler, Louis, Taylor, Michael D., Cinalli, Giuseppe, Zollo, Massimo

“…Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient…”
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MB-64ADOPTIVE CELL IMMUNOTHERAPY IN MEDULLOBLASTOMA BASED ON T CELLS REDIRECTED TOWARD TUMOR CELLS BY PRAME SPECIFIC αβTCR GENE MODIFICATION by Caruana, Ignazio, Orlando, Domenico, De Angelis, Biagio, Boffa, Iolanda, Guercio, Marika, Carai, Andrea, Massimi, Luca, Ferretti, Elisabetta, Miele, Evelina, Po, Agnese, Moseley, Annemarie, Hagedoorn, R.S., de Boer, R., Falkenburg, J.H.Frederik, Heemskerk, Mirjam H.M., Locatelli, Franco, Mastronuzzi, Angela, Quintarelli, amd Concetta

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