Search Results - "Boersma, M.G"

Computer-modeling-based QSARs for analyzing experimental data on biotransformation and toxicity by Soffers, A.E.M.F., Boersma, M.G., Vaes, W.H.J., Vervoort, J., Tyrakowska, B., Hermens, J.L.M., Rietjens, I.M.C.M.

“…Over the past decades the description of quantitative structure–activity relationships (QSARs) has been undertaken in order to find predictive models and/or…”
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Digestibility of energy and phosphorus in ten samples of distillers dried grains with solubles fed to growing pigs by Pedersen, C, Boersma, M.G, Stein, H.H

“…An experiment was conducted to measure DE and ME and the apparent total tract digestibility (ATTD) of energy, N, and P in distillers dried grains with solubles…”
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Energy and nutrient digestibility in NutriDense corn and other cereal grains fed to growing pigs by Pedersen, C, Boersma, M.G, Stein, H.H

“…Two experiments were conducted to measure the energy and nutrient digestibilities in NutriDense corn and other cereal grains. An additional objective was to…”
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Flavonoids and alkenylbenzenes; new concepts in bioactivation studies by Rietjens, I.M.C.M, Al-Husainy, W.A.A.M, Boersma, M.G

“…The present paper focuses on the biological reactive intermediates formed from two categories of botanical ingredients: flavonoids and alkenylbenzenes. The…”
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Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples by BRAND, Walter, BOERSMA, Marelle G, RIETJENS, Ivonne M. C. M, BIK, Hanneke, HOEK-VAN DEN HIL, Elisabeth F, VERVOORT, Jacques, BARRON, Denis, MEINL, Walter, GLATT, Hansruedi, WILLIAMSON, Gary, VAN BLADEREN, Peter J

“…Phase II metabolism by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) is the predominant metabolic pathway during the first-pass metabolism…”
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Identification of 14 Quercetin Phase II Mono- and Mixed Conjugates and Their Formation by Rat and Human Phase II in Vitro Model Systems by van der Woude, Hester, Boersma, Marelle G, Vervoort, Jacques, Rietjens, Ivonne M. C. M

“…In this study, the HPLC, UV−vis, LC-MS, and 1H NMR characteristics of 14 different phase II mono- and mixed conjugates of quercetin were determined, providing…”
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Physiologically based biokinetic (PBBK) modeling of safrole bioactivation and detoxification in humans as compared with rats by Martati, Erryana, Boersma, Marelle G, Spenkelink, Albertus, Khadka, Dambar B, van Bladeren, Peter J, Rietjens, Ivonne M C M, Punt, Ans

“…A physiologically based biokinetic (PBBK) model for the alkenylbenzene safrole in humans was developed based on in vitro- and in silico-derived kinetic…”
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Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat by Al-Subeihi, Ala' A.A., Spenkelink, Bert, Punt, Ans, Boersma, Marelle G., van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…This study defines a physiologically based kinetic (PBK) model for methyleugenol (ME) in human based on in vitro and in silico derived parameters. With the…”
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Formation of genotoxic compounds by medium pressure ultra violet treatment of nitrate rich water by Martijn, A.J, Boersma, M.G, Vervoort, Jacques, Rietjens, I, Kruithof, J.C

“…Genotoxic compounds were produced by full-scale medium pressure (MP) ultraviolet hydrogen peroxide (UV/H2O2) treatment of nitrate-rich pretreated surface…”
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Safety evaluation of neem ( Azadirachta indica) derived pesticides by Boeke, Sara J, Boersma, Marelle G, Alink, Gerrit M, van Loon, Joop J.A, van Huis, Arnold, Dicke, Marcel, Rietjens, Ivonne M.C.M

“…The neem tree, Azadirachta indica, provides many useful compounds that are used as pesticides and could be applied to protect stored seeds against insects…”
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Regioselectivity of Phase II Metabolism of Luteolin and Quercetin by UDP-Glucuronosyl Transferases by Boersma, Marelle G, van der Woude, Hester, Bogaards, Jan, Boeren, Sjef, Vervoort, Jacques, Cnubben, Nicole H. P, van Iersel, Marlou L. P. S, van Bladeren, Peter J, Rietjens, Ivonne M. C. M

“…The regioselectivity of phase II conjugation of flavonoids is expected to be of importance for their biological activity. In the present study, the…”
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Formation of genotoxic compounds by medium pressure ultraviolet treatment of nitrate-rich water by Martijn, A.J., Boersma, M.G., Vervoort, J.M., Rietjens, I.M.C.M., Kruithof, J.C.

“…Genotoxic compounds were produced by full-scale medium pressure (MP) ultraviolet hydrogen peroxide (UV/H2O2) treatment of nitrate-rich pretreated surface…”
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Physiologically Based Biokinetic (PBBK) Model for Safrole Bioactivation and Detoxification in Rats by Martati, E, Boersma, M. G, Spenkelink, A, Khadka, D. B, Punt, A, Vervoort, J, van Bladeren, P. J, Rietjens, I. M. C. M

“…A physiologically based biokinetic (PBBK) model for alkenylbenzene safrole in rats was developed using in vitro metabolic parameters determined using relevant…”
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Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat by Al-Subeihi, Ala′ A.A., Spenkelink, Bert, Rachmawati, Novalia, Boersma, Marelle G., Punt, Ans, Vervoort, Jacques, van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene methyleugenol in rat based on in vitro metabolic parameters…”
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Human Cytochrome P450 Enzyme Specificity for the Bioactivation of Estragole and Related Alkenylbenzenes by Jeurissen, Suzanne M. F., Punt, Ans, Boersma, Marelle G., Bogaards, Jan J. P., Fiamegos, Yiannis C., Schilter, Benoit, van Bladeren, Peter J., Cnubben, Nicole H. P., Rietjens, Ivonne M. C. M.

“…Human cytochrome P450 enzymes involved in the bioactivation of estragole to its proximate carcinogen 1‘-hydroxyestragole were identified and compared to the…”
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The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids by Rietjens, Ivonne M.C.M., Boersma, Marelle G., Haan, Laura de, Spenkelink, Bert, Awad, Hanem M., Cnubben, Nicole H.P., van Zanden, Jelmer J., Woude, Hester van der, Alink, Gerrit M., Koeman, Jan H.

“…Natural antioxidants like vitamin C, vitamin E, carotenoids, and polyphenols like flavonoids, are at present generally considered to be beneficial components…”
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Human Glutathione S-Transferase-Mediated Glutathione Conjugation of Curcumin and Efflux of These Conjugates in Caco-2 Cells by Usta, Mustafa, Wortelboer, Heleen M, Vervoort, Jacques, Boersma, Marelle G, Rietjens, Ivonne M. C. M, van Bladeren, Peter J, Cnubben, Nicole H. P

“…Curcumin, an α,β-unsaturated carbonyl compound, reacts with glutathione, leading to the formation of two monoglutathionyl curcumin conjugates. In the present…”
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Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk by Rietjens, Ivonne M C M, Boersma, Marelle G, van der Woude, Hester, Jeurissen, Suzanne M F, Schutte, Maaike E, Alink, Gerrit M

“…The present review focuses on the mechanisms of mutagenic action and the carcinogenic risk of two categories of botanical ingredients, namely the flavonoids…”
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Apparent and true total tract digestibility of phosphorus in field peas (Pisum sativum L.) by growing pigs by Stein, H.H, Boersma, M.G, Pedersen, C

“…The apparent (ATTD) and true (TTTD) total tract digestibility of P in field peas were measured using growing pigs. Two diets based on field peas without or…”
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Evaluation of Human Interindividual Variation in Bioactivation of Estragole Using Physiologically Based Biokinetic Modeling by Punt, Ans, Jeurissen, Suzanne M., Boersma, Marelle G., Delatour, Thierry, Scholz, Gabriele, Schilter, Benoît, van Bladeren, Peter J., Rietjens, Ivonne M. C. M.

“…The present study investigates interindividual variation in liver levels of the proximate carcinogenic metabolite of estragole, 1′-hydroxyestragole, due to…”
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