Search Results - "Boer, Pnina"

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity by Tarasenko, Nataly, Kessler-Icekson, Gania, Boer, Pnina, Inbal, Aida, Schlesinger, Hadassa, Phillips, Don R., Cutts, Suzanne M., Nudelman, Abraham, Rephaeli, Ada

“…Summary The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) has been shown to synergize doxorubicin (Dox) anticancer activity…”
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Abstract 77: The HDAC inhibitory prodrug AN-7 reduces the toxicity of doxorubicin, anti-Her2 and radiation while augmenting their anticancer efficacy by Tarasenko, Nataly, Cutts, Suzanne M., Lipsky, Yoav, Boer, Pnina, Nudelman, Abraham, Fenig, Eyal, Kessler-Icekson, Gan-Ia, Phillips, Don R., Rephaeli, Ada

“…The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7), has been shown to possess anticancer activity in vitro and in vivo and to…”
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Modulation of Glycogen Phosphorylase Activity Affects 5-Phosphoribosyl-1-Pyrophosphate Availability in Rat Hepatocyte Cultures by Boer, Pnina, Sperling, Oded

“…The effect of modulation of the rate of glycogenolysis on the availability of 5-phosphoribosyl-1- pyrophosphate (PRPP) was investigated in rat hepatocyte…”
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Decelerated rate of dendrite outgrowth from dopaminergic neurons in primary cultures from brains of hypoxanthine phosphoribosyltransferase-deficient knockout mice by Boer, Pnina, Brosh, Sara, Wasserman, Lina, Hammel, Ilan, Zoref-Shani, Esther, Sperling, Oded

“…Lesch–Nyhan syndrome (LNS), caused by the complete deficiency of hypoxanthine phosphoribosyltransferase (HPRT), is characterized by a neurological deficit, the…”
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Cyclic AMP decreases the availability of 5-phosphortoosyl-1-pyrophosphate and decelerates de novo purine synthesis in rat hepatocytes by Boer, Pnina, Giler, Shamai, Sperling, Oded

“…Cyclic adenosine monophosphate (cAMP) was found to decrease the availability of 5-phosphoribosyl-1-pyrophosphate (PRPP) and to decelerate the rate of de novo…”
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Elevated UTP and CTP content in cultured neurons from HPRT-deficient transgenic mice by Brosh, S, Boer, P, Sperling, O, Zoref-Shani, E

“…Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8.; HPRT) catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and…”
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Role of cellular ribose-5-phosphate content in the regulation of 5-phosphoribosyl-1-pyrophosphate and de novo purine synthesis in a human hepatoma cell line by Boer, Pnina, Sperling, Oded

“…5-Phosphoribosyl-1-pyrophosphate (PRPP) is an important regulator of de novo purine synthesis. However, the role of ribose-5-phosphate (R5P), the precursor for…”
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Cyclic AMP decreases the availability of 5-phosphoribosyl-1-pyrophosphate and decelerates de novo purine synthesis in rat hepatocytes by Boer, P, Giler, S, Sperling, O

“…Cyclic adenosine monophosphate (cAMP) was found to decrease the availability of 5-phosphoribosyl-1-pyrophosphate (PRPP) and to decelerate the rate of de novo…”
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HORMONE-INDUCED ACCELERATION OF PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AND OF PURINE SYNTHESIS IN MOUSE LIVER IN VIVO: 16 by Boer, Pnina, Brosh, Sara, Sperling, Oded

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Stimulation of ribose-5-phosphate and 5-phosphoribosyl-1-pyrophosphate generation by pyrroline-5-carboxylate in mouse liver in vivo: evidence for a regulatory role of ribose-5-phosphate availability in nucleotide synthesis by Boer, P, Sperling, O

“…Pyrroline-5-carboxylase (P5C), a physiological stimulator of hexose-monophosphate-pentose pathway activity, was found before to increase…”
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Acceleration of purine synthesis in mouse liver by glycogenolytic hormones by Boer, P, Mamet, R, Sperling, O

“…Administration (ip) into fed mice of glucagon, epinephrine, vasopressin, oxytocin, angiotensin II, and dibutyryl cyclic AMP (dbcAMP) resulted in a rapid…”
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Normal activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate in erythrocytes of patients with primary metabolic gout by Sperling, O, Boer, P, Brosh, S, Elazar, E, Szeinberg, A, de Vries, A

“…The activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate (PRPP) was studied in. The erythrocytes of 34…”
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