Search Results - "Boehme, Lisa"
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Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
Published in Nature communications (01-05-2018)“…Leprosy, a chronic infectious disease caused by Mycobacterium leprae ( M. leprae ), was very common in Europe till the 16th century. Here, we perform an…”
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Rapid screening of glomerular slit diaphragm integrity in larval zebrafish
Published in American journal of physiology. Renal physiology (01-11-2007)“…Gene array-type experiments have identified large numbers of genes thought to be important for the integrity of the glomerular slit diaphragm. Confirmation of…”
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Comparison of target enrichment strategies for ancient pathogen DNA
Published in BioTechniques (01-12-2020)“…In ancient DNA research, the degraded nature of the samples generally results in poor yields of highly fragmented DNA; targeted DNA enrichment is thus required…”
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The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
Published in Journal of experimental & clinical cancer research (21-10-2019)“…Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14 months after standard therapy with radiation…”
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Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations
Published in Scientific reports (30-04-2020)“…The highly polymorphic human leukocyte antigen (HLA) plays a crucial role in adaptive immunity and is associated with various complex diseases. Accurate…”
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Knockdown of the Hypertension-Associated Gene NOSTRIN Alters Glomerular Barrier Function in Zebrafish (Danio rerio)
Published in Hypertension (Dallas, Tex. 1979) (01-10-2013)“…Hypertension is one of the major risk factors for chronic kidney disease. Using quantitative trait loci analysis, we identified the gene of the F-BAR protein…”
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Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry
Published in Communications biology (25-01-2021)“…The Wartberg culture (WBC, 3500-2800 BCE) dates to the Late Neolithic period, a time of important demographic and cultural transformations in western Europe…”
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