Search Results - "Boehler, Jessica"

Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study by Boehler, Jessica F, Hogarth, Marshall W, Barberio, Matthew D, Novak, James S, Ghimbovschi, Svetlana, Brown, Kristy J, Alemo Munters, Li, Loell, Ingela, Chen, Yi-Wen, Gordish-Dressman, Heather, Alexanderson, Helene, Lundberg, Ingrid E, Nagaraju, Kanneboyina

“…To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to…”
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Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense oligonucleotides (PMO-AO) to exclude…”
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N-terminal titin fragment: a non-invasive, pharmacodynamic biomarker for microdystrophin efficacy by Boehler, Jessica F, Brown, Kristy J, Ricotti, Valeria, Morris, Carl A

“…Multiple clinical trials to assess the efficacy of AAV-directed gene transfer in participants with Duchenne muscular dystrophy (DMD) are ongoing. The success…”
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A novel estrogen receptor 1: sphingomyelin phosphodiesterase acid-like 3B pathway mediates rituximab response in myositis patients by Parkes, Joanna E, Boehler, Jessica F, Li, Ning, Kendra, Ryan M, O’Hanlon, Terrance P, Hoffman, Eric P, Peterson, Jennifer M, Miller, Frederick W, Rider, Lisa G, Nagaraju, Kanneboyina

“…Abstract Objectives The B-cell depleting biologic, rituximab, is used to treat refractory autoimmune myositis. However, the beneficial effects of rituximab…”
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Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis by Boehler, Jessica F, Horn, Adam, Novak, James S, Li, Ning, Ghimbovschi, Svetlana, Lundberg, Ingrid E, Alexanderson, Helene, Alemo Munters, Li, Jaiswal, Jyoti K, Nagaraju, Kanneboyina

“…The etiology of myositis is unknown. Although attempts to identify viruses in myositis skeletal muscle have failed, several studies have identified the…”
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Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits by Oaks, Adam W, Zamarbide, Marta, Tambunan, Dimira E, Santini, Emanuela, Di Costanzo, Stefania, Pond, Heather L, Johnson, Mark W, Lin, Jeff, Gonzalez, Dilenny M, Boehler, Jessica F, Wu, Guangying K, Klann, Eric, Walsh, Christopher A, Manzini, M Chiara

“…Loss-of-function (LOF) mutations in CC2D1A cause a spectrum of neurodevelopmental disorders, including intellectual disability, autism spectrum disorder, and…”
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Clinical potential of microdystrophin as a surrogate endpoint by Boehler, Jessica F, Brown, Kristy J, Beatka, Margaret, Gonzalez, J Patrick, Donisa Dreghici, Roxana, Soustek-Kramer, Meghan, McGonigle, Sharon, Ganot, Annie, Palmer, Timothy, Lowie, Caitlin, Chamberlain, Jeffrey S., Lawlor, Michael W, Morris, Carl A

“…•We directly address the similarities and difference between rationally designed microdystrophin proteins and ‘natural’ skipped dystrophins from both a…”
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Morpholino‐induced exon skipping stimulates cell‐mediated and humoral responses to dystrophin in mdx mice by Vila, Maria C, Novak, James S, Benny Klimek, Margaret, Li, Ning, Morales, Melissa, Fritz, Alexander G, Edwards, Katie, Boehler, Jessica F, Hogarth, Marshall W, Kinder, Travis B, Zhang, Aiping, Mazala, Davi, Fiorillo, Alyson A, Douglas, Bonnie, Chen, Yi‐Wen, van den Anker, John, Lu, Qi L, Hathout, Yetrib, Hoffman, Eric P, Partridge, Terence A, Nagaraju, Kanneboyina

“…Exon skipping is a promising genetic therapeutic strategy for restoring dystrophin expression in the treatment of Duchenne muscular dystrophy (DMD). The…”
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Membrane recruitment of nNOSµ in microdystrophin gene transfer to enhance durability by Boehler, Jessica F., Ricotti, Valeria, Gonzalez, J. Patrick, Soustek-Kramer, Meghan, Such, Lauren, Brown, Kristy J., Schneider, Joel S., Morris, Carl A.

“…Several gene transfer clinical trials are currently ongoing with the common aim of delivering a shortened version of dystrophin, termed a microdystrophin, for…”
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Creation and characterization of an immortalized canine myoblast cell line: Myok9 by López, Sara Mata, Balog-Alvarez, Cynthia, Canessa, Emily H., Hathout, Yetrib, Brown, Kristy J., Vitha, Stanislav, Bettis, Amanda K., Boehler, Jessica, Kornegay, Joe N., Nghiem, Peter P.

“…The availability of an in vitro canine cell line would reduce the need for dogs for primary in vitro cell culture and reduce overall cost in pre-clinical…”
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Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…The originally published version of this Article contained an error in Figure 6. In panel b, the top graph (BrdU 21–24d) and the bottom graph (BrdU 28–31d)…”
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Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle by Novak, James S., Hogarth, Marshall W., Boehler, Jessica F., Nearing, Marie, Vila, Maria C., Heredia, Raul, Fiorillo, Alyson A., Zhang, Aiping, Hathout, Yetrib, Hoffman, Eric P., Jaiswal, Jyoti K., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

“…In the original version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to…”
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Mitochondrial dysfunction and consequences in calpain-3-deficient muscle by Jahnke, Vanessa E, Peterson, Jennifer M, Van Der Meulen, Jack H, Boehler, Jessica, Uaesoontrachoon, Kitipong, Johnston, Helen K, Defour, Aurelia, Phadke, Aditi, Yu, Qing, Jaiswal, Jyoti K, Nagaraju, Kanneboyina

“…Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While…”
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Synthesis, Characterization, and Function of an RNA-Based Transfection Reagent by Jain, Harsh V, Boehler, Jessica F, Nagaraju, Kanneboyina, Beaucage, Serge L

“…A synthetic 8-mer, amphipathic, trans-acting poly-2'-O-methyluridylic thiophosphate triester RNA element (2'-OMeUtaPS) can be prepared using solid-phase…”
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Elusive sources of variability of dystrophin rescue by exon skipping by Vila, Maria Candida, Klimek, Margaret Benny, Novak, James S, Rayavarapu, Sree, Uaesoontrachoon, Kitipong, Boehler, Jessica F, Fiorillo, Alyson A, Hogarth, Marshall W, Zhang, Aiping, Shaughnessy, Conner, Gordish-Dressman, Heather, Burki, Umar, Straub, Volker, Lu, Qi Long, Partridge, Terence A, Brown, Kristy J, Hathout, Yetrib, van den Anker, John, Hoffman, Eric P, Nagaraju, Kanneboyina

“…Systemic delivery of anti-sense oligonucleotides to Duchenne muscular dystrophy (DMD) patients to induce de novo dystrophin protein expression in muscle (exon…”
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Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle by Defour, Aurelia, Medikayala, Sushma, Van der Meulen, Jack H, Hogarth, Marshall W, Holdreith, Nicholas, Malatras, Apostolos, Duddy, William, Boehler, Jessica, Nagaraju, Kanneboyina, Jaiswal, Jyoti K

“…Repair of skeletal muscle after sarcolemmal damage involves dysferlin and dysferlin-interacting proteins such as annexins. Mice and patient lacking dysferlin…”
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584. Myoblast Fusion Mediates Morpholino Entry and Exon Skipping In Dystrophic Muscle by Novak, James S., Nearing, Marie, Hogarth, Marshall W., Vila, Maria C., Boehler, Jessica F., Hoffman, Eric P., Nagaraju, Kanneboyina, Cirak, Sebahattin, Partridge, Terence A.

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Role of Epigenetic Mechanisms in the Pathogenesis of Idiopathic Inflammatory Myopathies by Boehler, Jessica Fineran

“…The idiopathic inflammatory myopathies (IIM) (polymyositis [PM], dermatomyositis [DM], and inclusion body myositis [IBM]) are a heterogeneous group of…”
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Effects of Chronic, Maximal Phosphorodiamidate Morpholino Oligomer (PMO) Dosing on Muscle Function and Dystrophin Restoration in a Mouse Model of Duchenne Muscular Dystrophy by Benny Klimek, Margaret E, Vila, Maria Candida, Edwards, Katie, Boehler, Jessica, Novak, James, Zhang, Aiping, Van der Meulen, Jack, Tatum, Kathleen, Quinn, James, Fiorillo, Alyson, Burki, Umar, Straub, Volker, Lu, Qi Long, Hathout, Yetrib, van Den Anker, John, Partridge, Terence A, Morales, Melissa, Hoffman, Eric, Nagaraju, Kanneboyina

“…Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is currently used in clinical development to treat Duchenne muscular dystrophy (DMD), with…”
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