Search Results - "Boeckx, Carolien"

Anti‐Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance by Boeckx, Carolien, Baay, Marc, Wouters, An, Specenier, Pol, Vermorken, Jan B., Peeters, Marc, Lardon, Filip

“…Targeted therapy against the epidermal growth factor receptor (EGFR) is one of the most promising molecular therapeutics for head and neck squamous cell…”
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Optimal Evaluation of Programmed Death Ligand-1 on Tumor Cells Versus Immune Cells Requires Different Detection Methods by Schats, Kelly A, Van Vré, Emily A, Boeckx, Carolien, De Bie, Martine, Schrijvers, Dorien M, Neyns, Bart, De Meester, Ingrid, Kockx, Mark M

“…- The benefit of programmed death ligand-1 (PD-L1) immunohistochemistry (IHC) as a method to select patients who may benefit from programmed death receptor-1…”
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Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins by Boeckx, Carolien, Op de Beeck, Ken, Wouters, An, Deschoolmeester, Vanessa, Limame, Ridha, Zwaenepoel, Karen, Specenier, Pol, Pauwels, Patrick, Vermorken, Jan B, Peeters, Marc, Van Camp, Guy, Baay, Marc, Lardon, Filip

“…Highlights • Gene expression profiles of cetuximab sensitive and resistant cells were compared. • Cetuximab resistant cells still exhibit RAS–MAPK signaling…”
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The intriguing interplay between therapies targeting the epidermal growth factor receptor, the hypoxic microenvironment and hypoxia-inducible factors by Wouters, An, Boeckx, Carolien, Vermorken, Jan B, Van den Weyngaert, Danielle, Peeters, Marc, Lardon, Filip

“…Despite their individual key roles in promoting cancer progression and treatment resistance, our knowledge about the impact of tumor hypoxia on the activity of…”
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The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines by Boeckx, Carolien, Van den Bossche, Jolien, De Pauw, Ines, Peeters, Marc, Lardon, Filip, Baay, Marc, Wouters, An

“…Increased expression of the epidermal growth factor receptor (EGFR) is observed in more than 90% of all head and neck squamous cell carcinomas (HNSCC)…”
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Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: implications for anti-EGFR treatment response by Boeckx, Carolien, Weyn, Christine, Vanden Bempt, Isabelle, Deschoolmeester, Vanessa, Wouters, An, Specenier, Pol, Van Laer, Carl, Van den Weyngaert, Danielle, Kockx, Mark, Vermorken, Jan B, Peeters, Marc, Pauwels, Patrick, Lardon, Filip, Baay, Marc

“…Targeted therapy against the Epidermal Growth Factor Receptor (EGFR) is among the most promising molecular therapeutics for Head and Neck Squamous Cell…”
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Validated programmed cell death ligand 1 immunohistochemistry assays (E1L3N and SP142) reveal similar immune cell staining patterns in melanoma when using the same sensitive detection system by Schats, Kelly A, Van Vré, Emily A, De Schepper, Stefanie, Boeckx, Carolien, Schrijvers, Dorien M, Waelput, Wim, Fransen, Erik, Vanden Bempt, Isabelle, Neyns, Bart, De Meester, Ingrid, Kockx, Mark M

“…Aims Tumour cell and/or immune cell programmed cell death ligand 1 (PD‐L1) expression is considered as a potential biomarker for anti‐PD1 and anti‐PD‐L1…”
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Expression analysis on archival material revisited: isolation and quantification of RNA extracted from FFPE samples by Deben, Christophe, Zwaenepoel, Karen, Boeckx, Carolien, Wouters, An, Pauwels, Patrick, Peeters, Marc, Lardon, Filip, Baay, Marc, Deschoolmeester, Vanessa

“…Formalin-fixed paraffin-embedded (FFPE) tissue is the most readily available source of RNA for the gene expression studies. The main disadvantage is the poor…”
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Abstract 1030: The intriguing interplay between EGFR inhibitors and the hypoxic microenvironment: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines by Boeckx, Carolien, Van den Bossche, Jolien, Baay, Marc, Deschoolmeester, Vanessa, Specenier, Pol, Vanderveken, Olivier, Van den Weyngaert, Danielle, Vermorken, Jan B., Peeters, Marc, Lardon, Filip, Wouters, An

“…Abstract Introduction: Since the epidermal growth factor receptor (EGFR) is overexpressed in more than 90% of all head and neck squamous cell carcinomas…”
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Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor by Boeckx, Carolien, Blockx, Lina, de Beeck, Ken Op, Limame, Ridha, Camp, Guy Van, Peeters, Marc, Vermorken, Jan B, Specenier, Pol, Wouters, An, Baay, Marc, Lardon, Filip

“…After an initial response to EGFR targeted therapy, secondary resistance almost invariably ensues, thereby limiting the clinical benefit of the drug. Hence, it…”
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Abstract 1898: Potential molecular mechanisms of intrinsic resistance to EGFR-targeting monoclonal antibodies in HNSCC by Boeckx, Carolien, Limame, Ridha, Beeck, Ken Op de, Wouters, An, Deschoolmeester, Vanessa, Specenier, Pol, Vermorken, Jan B., Peeters, Marc, Camp, Guy Van, Baay, Marc, Lardon, Filip

“…Abstract Background: Head and Neck Squamous Cell Carcinoma (HNSCC) comprises 90% of all head and neck cancers and is still a major cause of morbidity and…”
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Abstract 5628: Overcoming cetuximab resistance in HNSCC: the role of AURKB and DUSP6 by Boeckx, Carolien, Deschoolmeester, Vanessa, Wouters, An, Op de Beeckx, Ken, Pauwels, Patrick, Vanderveken, Olivier, van Camp, Guy, Vanden Berghe, Wim, Specenier, Pol, Vermorken, Jan B., Peeters, Marc, Baay, Marc, Lardon, Filip

“…Abstract Introduction: As the epidermal growth factor receptor (EGFR) is expressed in up to 90% of all HNSCC tumors and initiates important signaling pathways…”
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Abstract 280: RNA isolation from formalin-fixed paraffin-embedded material: A comparison of five commercially available RNA isolation kits by Boeckx, Carolien, Wouters, An, Vanessa, Deschoolmeester, Specenier, Pol, Pauwels, Patrick, Peeters, Marc, Pauwels, Bea, Baay, Marc, Lardon, Filip

“…Abstract Formalin-fixed paraffin-embedded (FFPE) tissue is the most common tissue specimen widely available. Moreover, long clinical follow-up is on hand…”
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Abstract 2122: KRAS mutation detection using high resolution melting analysis and its prognostic value in archival colorectal cancer tissues by Deschoolmeester, Vanessa, Boeckx, Carolien, Wuyts, Wim, Marck, Eric Van, Vermeulen, Peter, Pauwels, Patrick, Peeters, Marc, Lardon, Filip, Vermorken, Jan B., Baay, Marc

“…Abstract Introduction: The development of targeted therapies has created a pressing clinical need for the rapid and robust molecular characterization of…”
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Expression analysis on archival material: comparison of 5 commercially available RNA isolation kits for FFPE material by Boeckx, Carolien, Wouters, An, Pauwels, Bea, Deschoolmeester, Vanessa, Specenier, Pol, Lukaszuk, Krzysztof, Vermorken, Jan B, Pauwels, Patrick, Peeters, Marc, Lardon, Filip, Baay, Marc F D

“…Formalin-fixed paraffin-embedded (FFPE) tissue is the most common tissue specimen widely available. Moreover, long clinical follow-up is on hand. Therefore,…”
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